Rodent Cell Transformation and Immediate Early Gene Expression Following 60-Hz Magnetic Field Exposure
Some epidemiological studies suggest that exposure to power frequency magnetic fields (MFs) may be associated with an elevated risk of human cancer, but the experimental database remains limited and controversial. We investigated the hypothesis that 60-Hz MF action at the cellular level produces cha...
Gespeichert in:
| Veröffentlicht in: | Environmental health perspectives 1996-11, Vol.104 (11), p.1188-1198 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1198 |
|---|---|
| container_issue | 11 |
| container_start_page | 1188 |
| container_title | Environmental health perspectives |
| container_volume | 104 |
| creator | Balcer-Kubiczek, Elizabeth K. Zhang, Xiao-Feng Harrison, George H. McCready, Welton A. Shi, Zhong-Ming Han, Lin-Huang Abraham, John M. Ampey, Luther L. Meltzer, Stephen J. Jacobs, Maria C. Davis, Christopher C. |
| description | Some epidemiological studies suggest that exposure to power frequency magnetic fields (MFs) may be associated with an elevated risk of human cancer, but the experimental database remains limited and controversial. We investigated the hypothesis that 60-Hz MF action at the cellular level produces changes in gene expression that can result in neoplastic transformation. Twenty-four hour 200 μT continuous MF exposure produced negative results in two standard transformation systems (Syrian hamster embryo cells and C3H/10T 1/2 murine fibroblasts) with or without postexposure to a chemical promoter. This prompted a reexamination of previously reported MF-induced changes in gene expression in human HL60 cells. Extensive testing using both coded and uncoded analyses was negative for an MF effect. Using the same exposure conditions as in the transformation studies, no MF-induced changes in ornithine decarboxylase expression were observed in C3H/10T 1/2 cells, casting doubt on a promotional role of MF for the tested cells and experimental conditions. |
| doi_str_mv | 10.1289/ehp.961041188 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1469519</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>3432912</jstor_id><sourcerecordid>3432912</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3908-1e0c10319476f71a71c44704309a04aad98cc96af3c7abcf661791f91fd9b00b3</originalsourceid><addsrcrecordid>eNqFkc1rGzEQxUVpSZ20xxwDOpTeNp1ZafVxKRQTJ4GUQknPQtZqnQ27kiut89G_PjI2Jj0FBjTwfjze6BFyinCOtdLf_N36XAsEjqjUOzLDpqkrrWv-nswANFZCiuYjOc75HgBQCXFEjpRuNAc1I93v2Pow0bkfBnqbbMhdTKOd-hioDS29Hkff9nby9MKm4Zle-lDWp3XyOW-ZRRyG-NiHFRVQXf2jP-0q-Kl3dNH7od2SMW-S_0Q-dHbI_vP-PSF_Fhe386vq5tfl9fzHTeWYBlWhB4fAUHMpOolWouNcAmegLXBrW62c08J2zEm7dJ0QKDV2ZVq9BFiyE_J957veLEtwV05LdjDr1I82PZtoe_O_Evo7s4oPBrnQDepi8HVvkOLfjc-TGfvsyufY4OMmG6kECqzhTRAFcI21eBvknCsuWQGrHehSzDn57hAbwWyrNqVqc6i68Gevbz3Q-26L_mWn3-cpptdmNQNpGGd1CcheAKoAsHQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14448473</pqid></control><display><type>article</type><title>Rodent Cell Transformation and Immediate Early Gene Expression Following 60-Hz Magnetic Field Exposure</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><creator>Balcer-Kubiczek, Elizabeth K. ; Zhang, Xiao-Feng ; Harrison, George H. ; McCready, Welton A. ; Shi, Zhong-Ming ; Han, Lin-Huang ; Abraham, John M. ; Ampey, Luther L. ; Meltzer, Stephen J. ; Jacobs, Maria C. ; Davis, Christopher C.</creator><creatorcontrib>Balcer-Kubiczek, Elizabeth K. ; Zhang, Xiao-Feng ; Harrison, George H. ; McCready, Welton A. ; Shi, Zhong-Ming ; Han, Lin-Huang ; Abraham, John M. ; Ampey, Luther L. ; Meltzer, Stephen J. ; Jacobs, Maria C. ; Davis, Christopher C.</creatorcontrib><description>Some epidemiological studies suggest that exposure to power frequency magnetic fields (MFs) may be associated with an elevated risk of human cancer, but the experimental database remains limited and controversial. We investigated the hypothesis that 60-Hz MF action at the cellular level produces changes in gene expression that can result in neoplastic transformation. Twenty-four hour 200 μT continuous MF exposure produced negative results in two standard transformation systems (Syrian hamster embryo cells and C3H/10T 1/2 murine fibroblasts) with or without postexposure to a chemical promoter. This prompted a reexamination of previously reported MF-induced changes in gene expression in human HL60 cells. Extensive testing using both coded and uncoded analyses was negative for an MF effect. Using the same exposure conditions as in the transformation studies, no MF-induced changes in ornithine decarboxylase expression were observed in C3H/10T 1/2 cells, casting doubt on a promotional role of MF for the tested cells and experimental conditions.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.961041188</identifier><identifier>PMID: 8959408</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</publisher><subject>Animals ; Cell Line - radiation effects ; Cell lines ; Cell Transformation, Neoplastic ; Cricetinae ; Cultured cells ; Electromagnetic Fields - adverse effects ; Embryonic cells ; Environmental health ; Flasks ; Gene expression ; Gene Expression - radiation effects ; Genes ; HL-60 Cells - radiation effects ; Humans ; Magnetic fields ; Messenger RNA ; Mice ; Ornithine Decarboxylase - genetics ; RNA ; RNA, Messenger - analysis</subject><ispartof>Environmental health perspectives, 1996-11, Vol.104 (11), p.1188-1198</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3908-1e0c10319476f71a71c44704309a04aad98cc96af3c7abcf661791f91fd9b00b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3432912$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3432912$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,865,886,27929,27930,53796,53798,58022,58255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8959408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balcer-Kubiczek, Elizabeth K.</creatorcontrib><creatorcontrib>Zhang, Xiao-Feng</creatorcontrib><creatorcontrib>Harrison, George H.</creatorcontrib><creatorcontrib>McCready, Welton A.</creatorcontrib><creatorcontrib>Shi, Zhong-Ming</creatorcontrib><creatorcontrib>Han, Lin-Huang</creatorcontrib><creatorcontrib>Abraham, John M.</creatorcontrib><creatorcontrib>Ampey, Luther L.</creatorcontrib><creatorcontrib>Meltzer, Stephen J.</creatorcontrib><creatorcontrib>Jacobs, Maria C.</creatorcontrib><creatorcontrib>Davis, Christopher C.</creatorcontrib><title>Rodent Cell Transformation and Immediate Early Gene Expression Following 60-Hz Magnetic Field Exposure</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Some epidemiological studies suggest that exposure to power frequency magnetic fields (MFs) may be associated with an elevated risk of human cancer, but the experimental database remains limited and controversial. We investigated the hypothesis that 60-Hz MF action at the cellular level produces changes in gene expression that can result in neoplastic transformation. Twenty-four hour 200 μT continuous MF exposure produced negative results in two standard transformation systems (Syrian hamster embryo cells and C3H/10T 1/2 murine fibroblasts) with or without postexposure to a chemical promoter. This prompted a reexamination of previously reported MF-induced changes in gene expression in human HL60 cells. Extensive testing using both coded and uncoded analyses was negative for an MF effect. Using the same exposure conditions as in the transformation studies, no MF-induced changes in ornithine decarboxylase expression were observed in C3H/10T 1/2 cells, casting doubt on a promotional role of MF for the tested cells and experimental conditions.</description><subject>Animals</subject><subject>Cell Line - radiation effects</subject><subject>Cell lines</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cricetinae</subject><subject>Cultured cells</subject><subject>Electromagnetic Fields - adverse effects</subject><subject>Embryonic cells</subject><subject>Environmental health</subject><subject>Flasks</subject><subject>Gene expression</subject><subject>Gene Expression - radiation effects</subject><subject>Genes</subject><subject>HL-60 Cells - radiation effects</subject><subject>Humans</subject><subject>Magnetic fields</subject><subject>Messenger RNA</subject><subject>Mice</subject><subject>Ornithine Decarboxylase - genetics</subject><subject>RNA</subject><subject>RNA, Messenger - analysis</subject><issn>0091-6765</issn><issn>1552-9924</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1rGzEQxUVpSZ20xxwDOpTeNp1ZafVxKRQTJ4GUQknPQtZqnQ27kiut89G_PjI2Jj0FBjTwfjze6BFyinCOtdLf_N36XAsEjqjUOzLDpqkrrWv-nswANFZCiuYjOc75HgBQCXFEjpRuNAc1I93v2Pow0bkfBnqbbMhdTKOd-hioDS29Hkff9nby9MKm4Zle-lDWp3XyOW-ZRRyG-NiHFRVQXf2jP-0q-Kl3dNH7od2SMW-S_0Q-dHbI_vP-PSF_Fhe386vq5tfl9fzHTeWYBlWhB4fAUHMpOolWouNcAmegLXBrW62c08J2zEm7dJ0QKDV2ZVq9BFiyE_J957veLEtwV05LdjDr1I82PZtoe_O_Evo7s4oPBrnQDepi8HVvkOLfjc-TGfvsyufY4OMmG6kECqzhTRAFcI21eBvknCsuWQGrHehSzDn57hAbwWyrNqVqc6i68Gevbz3Q-26L_mWn3-cpptdmNQNpGGd1CcheAKoAsHQ</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Balcer-Kubiczek, Elizabeth K.</creator><creator>Zhang, Xiao-Feng</creator><creator>Harrison, George H.</creator><creator>McCready, Welton A.</creator><creator>Shi, Zhong-Ming</creator><creator>Han, Lin-Huang</creator><creator>Abraham, John M.</creator><creator>Ampey, Luther L.</creator><creator>Meltzer, Stephen J.</creator><creator>Jacobs, Maria C.</creator><creator>Davis, Christopher C.</creator><general>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19961101</creationdate><title>Rodent Cell Transformation and Immediate Early Gene Expression Following 60-Hz Magnetic Field Exposure</title><author>Balcer-Kubiczek, Elizabeth K. ; Zhang, Xiao-Feng ; Harrison, George H. ; McCready, Welton A. ; Shi, Zhong-Ming ; Han, Lin-Huang ; Abraham, John M. ; Ampey, Luther L. ; Meltzer, Stephen J. ; Jacobs, Maria C. ; Davis, Christopher C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3908-1e0c10319476f71a71c44704309a04aad98cc96af3c7abcf661791f91fd9b00b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Cell Line - radiation effects</topic><topic>Cell lines</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cricetinae</topic><topic>Cultured cells</topic><topic>Electromagnetic Fields - adverse effects</topic><topic>Embryonic cells</topic><topic>Environmental health</topic><topic>Flasks</topic><topic>Gene expression</topic><topic>Gene Expression - radiation effects</topic><topic>Genes</topic><topic>HL-60 Cells - radiation effects</topic><topic>Humans</topic><topic>Magnetic fields</topic><topic>Messenger RNA</topic><topic>Mice</topic><topic>Ornithine Decarboxylase - genetics</topic><topic>RNA</topic><topic>RNA, Messenger - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balcer-Kubiczek, Elizabeth K.</creatorcontrib><creatorcontrib>Zhang, Xiao-Feng</creatorcontrib><creatorcontrib>Harrison, George H.</creatorcontrib><creatorcontrib>McCready, Welton A.</creatorcontrib><creatorcontrib>Shi, Zhong-Ming</creatorcontrib><creatorcontrib>Han, Lin-Huang</creatorcontrib><creatorcontrib>Abraham, John M.</creatorcontrib><creatorcontrib>Ampey, Luther L.</creatorcontrib><creatorcontrib>Meltzer, Stephen J.</creatorcontrib><creatorcontrib>Jacobs, Maria C.</creatorcontrib><creatorcontrib>Davis, Christopher C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balcer-Kubiczek, Elizabeth K.</au><au>Zhang, Xiao-Feng</au><au>Harrison, George H.</au><au>McCready, Welton A.</au><au>Shi, Zhong-Ming</au><au>Han, Lin-Huang</au><au>Abraham, John M.</au><au>Ampey, Luther L.</au><au>Meltzer, Stephen J.</au><au>Jacobs, Maria C.</au><au>Davis, Christopher C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rodent Cell Transformation and Immediate Early Gene Expression Following 60-Hz Magnetic Field Exposure</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>104</volume><issue>11</issue><spage>1188</spage><epage>1198</epage><pages>1188-1198</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Some epidemiological studies suggest that exposure to power frequency magnetic fields (MFs) may be associated with an elevated risk of human cancer, but the experimental database remains limited and controversial. We investigated the hypothesis that 60-Hz MF action at the cellular level produces changes in gene expression that can result in neoplastic transformation. Twenty-four hour 200 μT continuous MF exposure produced negative results in two standard transformation systems (Syrian hamster embryo cells and C3H/10T 1/2 murine fibroblasts) with or without postexposure to a chemical promoter. This prompted a reexamination of previously reported MF-induced changes in gene expression in human HL60 cells. Extensive testing using both coded and uncoded analyses was negative for an MF effect. Using the same exposure conditions as in the transformation studies, no MF-induced changes in ornithine decarboxylase expression were observed in C3H/10T 1/2 cells, casting doubt on a promotional role of MF for the tested cells and experimental conditions.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>8959408</pmid><doi>10.1289/ehp.961041188</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 1996-11, Vol.104 (11), p.1188-1198 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1469519 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Animals Cell Line - radiation effects Cell lines Cell Transformation, Neoplastic Cricetinae Cultured cells Electromagnetic Fields - adverse effects Embryonic cells Environmental health Flasks Gene expression Gene Expression - radiation effects Genes HL-60 Cells - radiation effects Humans Magnetic fields Messenger RNA Mice Ornithine Decarboxylase - genetics RNA RNA, Messenger - analysis |
| title | Rodent Cell Transformation and Immediate Early Gene Expression Following 60-Hz Magnetic Field Exposure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T14%3A24%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rodent%20Cell%20Transformation%20and%20Immediate%20Early%20Gene%20Expression%20Following%2060-Hz%20Magnetic%20Field%20Exposure&rft.jtitle=Environmental%20health%20perspectives&rft.au=Balcer-Kubiczek,%20Elizabeth%20K.&rft.date=1996-11-01&rft.volume=104&rft.issue=11&rft.spage=1188&rft.epage=1198&rft.pages=1188-1198&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.961041188&rft_dat=%3Cjstor_pubme%3E3432912%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14448473&rft_id=info:pmid/8959408&rft_jstor_id=3432912&rfr_iscdi=true |