Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain

Mammalian cells express two genetically distinct isoforms of DNA topoisomerase II, designated topoisomerase IIα and topoisomerase IIβ. We have recently shown that mouse topoisomerase IIα can substitute for the yeast topoisomerase II enzyme and complement yeast top2 mutations. This functional complem...

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