Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique

Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene ( SCN5A ) mutations. In this study, we used the âdynamic action potential clampâ (dAPC) technique to effectively replace the native sodium current ( I Na ) of the PriebeâBeuckelmann human ventricular cell model with wild-type (W...

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Veröffentlicht in:	The Journal of physiology 2006-01, Vol.570 (2), p.237-250
Hauptverfasser:	Berecki, Géza, Zegers, Jan G., Bhuiyan, Zahurul A., Verkerk, Arie O., Wilders, Ronald, Van Ginneken, Antoni C. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - physiopathology Cell Line Cellular Electrophysiology Heart Ventricles - cytology Humans Kidney - cytology Kidney - embryology Kidney - physiology Long QT Syndrome - genetics Long QT Syndrome - physiopathology Models, Biological Mutation NAV1.5 Voltage-Gated Sodium Channel Patch-Clamp Techniques Sodium Channels - genetics Sodium Channels - physiology Time Factors Transfection Ventricular Function
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