Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon
The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma concentrations of alpha‐hydroxymetoprolol and urinary excretion of the main metabolites were also measured. Plasma...
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| Veröffentlicht in: | British journal of clinical pharmacology 1985, Vol.19 (S2), p.113S-118S |
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| container_end_page | 118S |
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| container_issue | S2 |
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| container_title | British journal of clinical pharmacology |
| container_volume | 19 |
| creator | Godbillon, J Evard, D Vidon, N Duval, M Schoeller, JP Bernier, JJ Hirtz, J |
| description | The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma concentrations of alpha‐hydroxymetoprolol and urinary excretion of the main metabolites were also measured. Plasma profiles of metoprolol after colonic and jejunal perfusion were similar, and the relative bioavailabilities of the drug from these two regions of the gut were not significantly different. The concentrations of alpha‐hydroxymetoprolol, the major metabolite in plasma, were similar after jejunal and colonic perfusion, but higher than those observed after intravenous administration. The percentage of the dose recovered in urine over 24 h as two metabolites was not significantly influenced by the route of administration. |
| doi_str_mv | 10.1111/j.1365-2125.1985.tb02751.x |
| format | Article |
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III. Metoprolol in the colon</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Godbillon, J ; Evard, D ; Vidon, N ; Duval, M ; Schoeller, JP ; Bernier, JJ ; Hirtz, J</creator><creatorcontrib>Godbillon, J ; Evard, D ; Vidon, N ; Duval, M ; Schoeller, JP ; Bernier, JJ ; Hirtz, J</creatorcontrib><description>The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma concentrations of alpha‐hydroxymetoprolol and urinary excretion of the main metabolites were also measured. Plasma profiles of metoprolol after colonic and jejunal perfusion were similar, and the relative bioavailabilities of the drug from these two regions of the gut were not significantly different. The concentrations of alpha‐hydroxymetoprolol, the major metabolite in plasma, were similar after jejunal and colonic perfusion, but higher than those observed after intravenous administration. The percentage of the dose recovered in urine over 24 h as two metabolites was not significantly influenced by the route of administration.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1985.tb02751.x</identifier><identifier>PMID: 4005112</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Basic Absorption Studies ; Colon - metabolism ; Female ; Humans ; Intestinal Absorption ; Kinetics ; Male ; Metoprolol - analogs & derivatives ; Metoprolol - blood ; Metoprolol - metabolism ; Metoprolol - urine ; Phenylacetates - urine</subject><ispartof>British journal of clinical pharmacology, 1985, Vol.19 (S2), p.113S-118S</ispartof><rights>1985 The British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3921-d8bb39cf6bb0b68a26c8cedd13a6c0941adfc15ad0946fa3236b49e14af4cf3f3</citedby><cites>FETCH-LOGICAL-c3921-d8bb39cf6bb0b68a26c8cedd13a6c0941adfc15ad0946fa3236b49e14af4cf3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4005112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Godbillon, J</creatorcontrib><creatorcontrib>Evard, D</creatorcontrib><creatorcontrib>Vidon, N</creatorcontrib><creatorcontrib>Duval, M</creatorcontrib><creatorcontrib>Schoeller, JP</creatorcontrib><creatorcontrib>Bernier, JJ</creatorcontrib><creatorcontrib>Hirtz, J</creatorcontrib><title>Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma concentrations of alpha‐hydroxymetoprolol and urinary excretion of the main metabolites were also measured. Plasma profiles of metoprolol after colonic and jejunal perfusion were similar, and the relative bioavailabilities of the drug from these two regions of the gut were not significantly different. The concentrations of alpha‐hydroxymetoprolol, the major metabolite in plasma, were similar after jejunal and colonic perfusion, but higher than those observed after intravenous administration. The percentage of the dose recovered in urine over 24 h as two metabolites was not significantly influenced by the route of administration.</description><subject>Adult</subject><subject>Basic Absorption Studies</subject><subject>Colon - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Kinetics</subject><subject>Male</subject><subject>Metoprolol - analogs & derivatives</subject><subject>Metoprolol - blood</subject><subject>Metoprolol - metabolism</subject><subject>Metoprolol - urine</subject><subject>Phenylacetates - urine</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcFvFCEUxonR1LX6J5gQD95m5MHA7njQ1I3aSdroQc8EGNiymYEVZmv738t0N5t6LBcefO_7eOSH0DsgNZT1YVsDE7yiQHkN7YrXkyZ0yaG-e4YWJ-k5WhBGRMUph5foVc5bQoCB4GforCGEA9AFsl24tXnyGzX5GHB0uE_7DVY6x7R7uHIpjni6sXij8pSiD9PcH9SAp6TMNFtGFWrcdV2Nr-0UdykOccA-PLhMOYTX6IVTQ7Zvjvs5-v3t66_1ZXX143u3vriqDGspVP1Ka9YaJ7QmWqwUFWZlbN8DU8KQtgHVOwNc9aUWTjHKhG5aC41yjXHMsXP06ZC72-vR9saGMuMgd8mPKt3LqLz8Xwn-Rm7irYRGsCVvS8D7Y0CKf_blo3L02dhhUMHGfZZLAbxpWloaPx4aTYo5J-tOjwCRMyS5lTMJOZOQMyR5hCTvivnt4zFP1iOVon8-6H_9YO-fkCy_rH_OFfsHd8elTA</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>Godbillon, J</creator><creator>Evard, D</creator><creator>Vidon, N</creator><creator>Duval, M</creator><creator>Schoeller, JP</creator><creator>Bernier, JJ</creator><creator>Hirtz, J</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>1985</creationdate><title>Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon</title><author>Godbillon, J ; Evard, D ; Vidon, N ; Duval, M ; Schoeller, JP ; Bernier, JJ ; Hirtz, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3921-d8bb39cf6bb0b68a26c8cedd13a6c0941adfc15ad0946fa3236b49e14af4cf3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Basic Absorption Studies</topic><topic>Colon - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Kinetics</topic><topic>Male</topic><topic>Metoprolol - analogs & derivatives</topic><topic>Metoprolol - blood</topic><topic>Metoprolol - metabolism</topic><topic>Metoprolol - urine</topic><topic>Phenylacetates - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godbillon, J</creatorcontrib><creatorcontrib>Evard, D</creatorcontrib><creatorcontrib>Vidon, N</creatorcontrib><creatorcontrib>Duval, M</creatorcontrib><creatorcontrib>Schoeller, JP</creatorcontrib><creatorcontrib>Bernier, JJ</creatorcontrib><creatorcontrib>Hirtz, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godbillon, J</au><au>Evard, D</au><au>Vidon, N</au><au>Duval, M</au><au>Schoeller, JP</au><au>Bernier, JJ</au><au>Hirtz, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1985</date><risdate>1985</risdate><volume>19</volume><issue>S2</issue><spage>113S</spage><epage>118S</epage><pages>113S-118S</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><abstract>The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma concentrations of alpha‐hydroxymetoprolol and urinary excretion of the main metabolites were also measured. Plasma profiles of metoprolol after colonic and jejunal perfusion were similar, and the relative bioavailabilities of the drug from these two regions of the gut were not significantly different. The concentrations of alpha‐hydroxymetoprolol, the major metabolite in plasma, were similar after jejunal and colonic perfusion, but higher than those observed after intravenous administration. The percentage of the dose recovered in urine over 24 h as two metabolites was not significantly influenced by the route of administration.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>4005112</pmid><doi>10.1111/j.1365-2125.1985.tb02751.x</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1985, Vol.19 (S2), p.113S-118S |
| issn | 0306-5251 1365-2125 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Basic Absorption Studies Colon - metabolism Female Humans Intestinal Absorption Kinetics Male Metoprolol - analogs & derivatives Metoprolol - blood Metoprolol - metabolism Metoprolol - urine Phenylacetates - urine |
| title | Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon |
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