Red wine contains a potent inhibitor of phenolsulphotransferase
Many ethanolic drinks, especially red wine, contain potent inhibitors of phenolsulphotransferase. At a dilution of 1/75 from the original beverage, extracts from six types of red wine inhibited human platelet phenolsulphotransferase P by a mean of 99% and human platelet phenolsulphotransferase M by...
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| Veröffentlicht in: | British journal of clinical pharmacology 1985-02, Vol.19 (2), p.275-278 |
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| container_title | British journal of clinical pharmacology |
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| creator | Littlewood, JT Glover, V Sandler, M |
| description | Many ethanolic drinks, especially red wine, contain potent inhibitors of phenolsulphotransferase. At a dilution of 1/75 from the original beverage, extracts from six types of red wine inhibited human platelet phenolsulphotransferase P by a mean of 99% and human platelet phenolsulphotransferase M by 12%. Such extracts had no significant effect on rat liver monoamine oxidase A or human platelet monoamine oxidase B. The inhibitors, which have not yet been identified, can be extracted into ethyl acetate at acid or neutral pH. Thus, they are not monoamines. Flavonoid phenols are plausible candidates. As phenolsulphotransferase M and P are involved in the metabolism of many phenols, including drugs, the inhibition of these enzymes could result in the enhancement of pharmacological potency and have important clinical consequences. |
| doi_str_mv | 10.1111/j.1365-2125.1985.tb02644.x |
| format | Article |
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At a dilution of 1/75 from the original beverage, extracts from six types of red wine inhibited human platelet phenolsulphotransferase P by a mean of 99% and human platelet phenolsulphotransferase M by 12%. Such extracts had no significant effect on rat liver monoamine oxidase A or human platelet monoamine oxidase B. The inhibitors, which have not yet been identified, can be extracted into ethyl acetate at acid or neutral pH. Thus, they are not monoamines. Flavonoid phenols are plausible candidates. 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At a dilution of 1/75 from the original beverage, extracts from six types of red wine inhibited human platelet phenolsulphotransferase P by a mean of 99% and human platelet phenolsulphotransferase M by 12%. Such extracts had no significant effect on rat liver monoamine oxidase A or human platelet monoamine oxidase B. The inhibitors, which have not yet been identified, can be extracted into ethyl acetate at acid or neutral pH. Thus, they are not monoamines. Flavonoid phenols are plausible candidates. As phenolsulphotransferase M and P are involved in the metabolism of many phenols, including drugs, the inhibition of these enzymes could result in the enhancement of pharmacological potency and have important clinical consequences.</description><subject>Alcoholic Beverages - analysis</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Arylsulfotransferase</subject><subject>Blood Platelets - enzymology</subject><subject>Exact sciences and technology</subject><subject>Humans</subject><subject>Liver - enzymology</subject><subject>Monoamine Oxidase - metabolism</subject><subject>Other techniques and industries</subject><subject>Rats</subject><subject>Sulfurtransferases - antagonists & inhibitors</subject><subject>Transferases - antagonists & inhibitors</subject><subject>Vitaceae</subject><subject>Wine - analysis</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV2L1DAUhoMo6-zqTxCKyLI3rfk6aeqFiw7qLiwootchTRMnQ6epSWc__r0pUwa9UcxNAu9zDm94EHpJcEXyeb2tCBNQUkKhIo2EamoxFZxX94_Q6hg9RivMsCiBAnmKTlPaYkwYEXCCTpiEGotmhS6_2q6484MtTBgm7YdU6GIMkx2mwg8b3_opxCK4YtzYIfRp34-bMEU9JGejTvYZeuJ0n-zz5T5D3z9--La-Km8-f7pev7spDZfAy5Y3jYEGWyOZaQG3uYCVIIhwtaHaOtwKgruONFrXjkKnOQgjGo6dJE5adobeHvaO-3ZnO5P7Rd2rMfqdjg8qaK_-TAa_UT_CrSJcsJqyvOB8WRDDz71Nk9r5ZGzf68GGfVK1wAIopRm8-CtIJKsZBgH8nzsJhxqwhAy-OYAmhpSidcfiBKtZqdqq2ZuavalZqVqUqvs8_OL3rx9HF4c5f7XkOhnduyzH-HTEpGTQCJKxywN253v78B8F1Pv1l_nFfgFpor7b</recordid><startdate>198502</startdate><enddate>198502</enddate><creator>Littlewood, JT</creator><creator>Glover, V</creator><creator>Sandler, M</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198502</creationdate><title>Red wine contains a potent inhibitor of phenolsulphotransferase</title><author>Littlewood, JT ; Glover, V ; Sandler, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4854-b499c590ec83cb50b385e85616f7c2aef0b610dd19aa7f25da456c6940f81f8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Alcoholic Beverages - analysis</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Arylsulfotransferase</topic><topic>Blood Platelets - enzymology</topic><topic>Exact sciences and technology</topic><topic>Humans</topic><topic>Liver - enzymology</topic><topic>Monoamine Oxidase - metabolism</topic><topic>Other techniques and industries</topic><topic>Rats</topic><topic>Sulfurtransferases - antagonists & inhibitors</topic><topic>Transferases - antagonists & inhibitors</topic><topic>Vitaceae</topic><topic>Wine - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Littlewood, JT</creatorcontrib><creatorcontrib>Glover, V</creatorcontrib><creatorcontrib>Sandler, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Littlewood, JT</au><au>Glover, V</au><au>Sandler, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red wine contains a potent inhibitor of phenolsulphotransferase</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1985-02</date><risdate>1985</risdate><volume>19</volume><issue>2</issue><spage>275</spage><epage>278</epage><pages>275-278</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>Many ethanolic drinks, especially red wine, contain potent inhibitors of phenolsulphotransferase. At a dilution of 1/75 from the original beverage, extracts from six types of red wine inhibited human platelet phenolsulphotransferase P by a mean of 99% and human platelet phenolsulphotransferase M by 12%. Such extracts had no significant effect on rat liver monoamine oxidase A or human platelet monoamine oxidase B. The inhibitors, which have not yet been identified, can be extracted into ethyl acetate at acid or neutral pH. Thus, they are not monoamines. Flavonoid phenols are plausible candidates. As phenolsulphotransferase M and P are involved in the metabolism of many phenols, including drugs, the inhibition of these enzymes could result in the enhancement of pharmacological potency and have important clinical consequences.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3857069</pmid><doi>10.1111/j.1365-2125.1985.tb02644.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1985-02, Vol.19 (2), p.275-278 |
| issn | 0306-5251 1365-2125 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1463723 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alcoholic Beverages - analysis Animals Applied sciences Arylsulfotransferase Blood Platelets - enzymology Exact sciences and technology Humans Liver - enzymology Monoamine Oxidase - metabolism Other techniques and industries Rats Sulfurtransferases - antagonists & inhibitors Transferases - antagonists & inhibitors Vitaceae Wine - analysis |
| title | Red wine contains a potent inhibitor of phenolsulphotransferase |
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