Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man
A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p‐chlorophenolic (PCP) ester of CPIB. Plasma concentrations of CPIB when administered with food were higher than th...
Gespeichert in:
| Veröffentlicht in: | British journal of clinical pharmacology 1984-03, Vol.17 (3), p.341-345 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 345 |
|---|---|
| container_issue | 3 |
| container_start_page | 341 |
| container_title | British journal of clinical pharmacology |
| container_volume | 17 |
| creator | Houin, G Shastri, RA Barre, J Pinchon, B Tillement, JP |
| description | A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p‐chlorophenolic (PCP) ester of CPIB. Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 +/‐ 4.6 mg l‐1 as against a value of 15.2 +/‐ 6.9 mg l‐1 in the latter (P less than 0.01). The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug. |
| doi_str_mv | 10.1111/j.1365-2125.1984.tb02351.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1463364</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81022662</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3641-1ad32365ce6bd18ae9ddb2b8c252cb110b2273edd2b87ec77047efa2be2c7b643</originalsourceid><addsrcrecordid>eNqVUcuO1DAQtBCrZVj4BKQIIW7J-pHYWQ4gGPFYaSU4wNmynQ7jkccOdgIzNz6Bb9wvwWGi0e4RX-yuqi53qxB6TnBF8rncVoTxpqSENhW5autq1JiyhlT7B2h1oh6iFWaYlw1tyCP0OKUtxoQR3pyjcy4IbblYoe21790E3kAR-qIPoSuCL8YNFEqnEIfR5jIzMzLc_v5jNi7EMGzAB2dNAWmEOPN38P3BpqCn8RCzQBnbFdYXO-WfoLNeuQRPl_sCffvw_uv6U3nz-eP1-u1NaRivSUlUx2jewQDXHWkVXHWdpro1tKFGE4I1pYJB12VMgBEC1wJ6RTVQIzSv2QV6ffQdJr2DzoAfo3JyiHan4kEGZeV9xtuN_B5-SlJzxv4ZvFwMYvgx5RXlziYDzikPYUqyJZhSzmkWvjoKTQwpRehPnxAs56TkVs5xyDkOOScll6TkPjc_uzvmqXWJJvMvFl4lo1wflTc2nWRtzQRj8wxvjrJf1sHhPwaQ79Zf5hf7C2PstQI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81022662</pqid></control><display><type>article</type><title>Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Houin, G ; Shastri, RA ; Barre, J ; Pinchon, B ; Tillement, JP</creator><creatorcontrib>Houin, G ; Shastri, RA ; Barre, J ; Pinchon, B ; Tillement, JP</creatorcontrib><description>A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p‐chlorophenolic (PCP) ester of CPIB. Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 +/‐ 4.6 mg l‐1 as against a value of 15.2 +/‐ 6.9 mg l‐1 in the latter (P less than 0.01). The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1984.tb02351.x</identifier><identifier>PMID: 6712867</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Clofibrate - analogs & derivatives ; Clofibric Acid - analogs & derivatives ; Clofibric Acid - blood ; Clofibric Acid - metabolism ; Clofibric Acid - urine ; Fasting ; Female ; Food ; General and cellular metabolism. Vitamins ; Humans ; Intestinal Absorption ; Kinetics ; Male ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>British journal of clinical pharmacology, 1984-03, Vol.17 (3), p.341-345</ispartof><rights>1984 The British Pharmacological Society</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3641-1ad32365ce6bd18ae9ddb2b8c252cb110b2273edd2b87ec77047efa2be2c7b643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8437332$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6712867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Houin, G</creatorcontrib><creatorcontrib>Shastri, RA</creatorcontrib><creatorcontrib>Barre, J</creatorcontrib><creatorcontrib>Pinchon, B</creatorcontrib><creatorcontrib>Tillement, JP</creatorcontrib><title>Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p‐chlorophenolic (PCP) ester of CPIB. Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 +/‐ 4.6 mg l‐1 as against a value of 15.2 +/‐ 6.9 mg l‐1 in the latter (P less than 0.01). The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Clofibrate - analogs & derivatives</subject><subject>Clofibric Acid - analogs & derivatives</subject><subject>Clofibric Acid - blood</subject><subject>Clofibric Acid - metabolism</subject><subject>Clofibric Acid - urine</subject><subject>Fasting</subject><subject>Female</subject><subject>Food</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUcuO1DAQtBCrZVj4BKQIIW7J-pHYWQ4gGPFYaSU4wNmynQ7jkccOdgIzNz6Bb9wvwWGi0e4RX-yuqi53qxB6TnBF8rncVoTxpqSENhW5autq1JiyhlT7B2h1oh6iFWaYlw1tyCP0OKUtxoQR3pyjcy4IbblYoe21790E3kAR-qIPoSuCL8YNFEqnEIfR5jIzMzLc_v5jNi7EMGzAB2dNAWmEOPN38P3BpqCn8RCzQBnbFdYXO-WfoLNeuQRPl_sCffvw_uv6U3nz-eP1-u1NaRivSUlUx2jewQDXHWkVXHWdpro1tKFGE4I1pYJB12VMgBEC1wJ6RTVQIzSv2QV6ffQdJr2DzoAfo3JyiHan4kEGZeV9xtuN_B5-SlJzxv4ZvFwMYvgx5RXlziYDzikPYUqyJZhSzmkWvjoKTQwpRehPnxAs56TkVs5xyDkOOScll6TkPjc_uzvmqXWJJvMvFl4lo1wflTc2nWRtzQRj8wxvjrJf1sHhPwaQ79Zf5hf7C2PstQI</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>Houin, G</creator><creator>Shastri, RA</creator><creator>Barre, J</creator><creator>Pinchon, B</creator><creator>Tillement, JP</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198403</creationdate><title>Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man</title><author>Houin, G ; Shastri, RA ; Barre, J ; Pinchon, B ; Tillement, JP</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3641-1ad32365ce6bd18ae9ddb2b8c252cb110b2273edd2b87ec77047efa2be2c7b643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Clofibrate - analogs & derivatives</topic><topic>Clofibric Acid - analogs & derivatives</topic><topic>Clofibric Acid - blood</topic><topic>Clofibric Acid - metabolism</topic><topic>Clofibric Acid - urine</topic><topic>Fasting</topic><topic>Female</topic><topic>Food</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Houin, G</creatorcontrib><creatorcontrib>Shastri, RA</creatorcontrib><creatorcontrib>Barre, J</creatorcontrib><creatorcontrib>Pinchon, B</creatorcontrib><creatorcontrib>Tillement, JP</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Houin, G</au><au>Shastri, RA</au><au>Barre, J</au><au>Pinchon, B</au><au>Tillement, JP</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1984-03</date><risdate>1984</risdate><volume>17</volume><issue>3</issue><spage>341</spage><epage>345</epage><pages>341-345</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>A study was designed to investigate the effect of a fatty meal on the absorption of chlorophenoxyisobutyric acid (CPIB) in six healthy adult volunteers after oral administration of the p‐chlorophenolic (PCP) ester of CPIB. Plasma concentrations of CPIB when administered with food were higher than those observed in the fasting state. The Cmax in the former case was 24.0 +/‐ 4.6 mg l‐1 as against a value of 15.2 +/‐ 6.9 mg l‐1 in the latter (P less than 0.01). The pharmacokinetic parameters measured were found to be linear with the dose administered. This could be due to low plasma concentrations of CPIB unable to cause a saturation of the plasma protein binding of this drug. It is concluded that a fatty meal enhances the absorption of this hypolipidaemic drug.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6712867</pmid><doi>10.1111/j.1365-2125.1984.tb02351.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1984-03, Vol.17 (3), p.341-345 |
| issn | 0306-5251 1365-2125 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1463364 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences Clofibrate - analogs & derivatives Clofibric Acid - analogs & derivatives Clofibric Acid - blood Clofibric Acid - metabolism Clofibric Acid - urine Fasting Female Food General and cellular metabolism. Vitamins Humans Intestinal Absorption Kinetics Male Medical sciences Pharmacology. Drug treatments |
| title | Influence of food on the absorption of the p‐chlorophenolic ester of chlorophenoxyisobutyric acid in man |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T10%3A52%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20food%20on%20the%20absorption%20of%20the%20p%E2%80%90chlorophenolic%20ester%20of%20chlorophenoxyisobutyric%20acid%20in%20man&rft.jtitle=British%20journal%20of%20clinical%20pharmacology&rft.au=Houin,%20G&rft.date=1984-03&rft.volume=17&rft.issue=3&rft.spage=341&rft.epage=345&rft.pages=341-345&rft.issn=0306-5251&rft.eissn=1365-2125&rft.coden=BCPHBM&rft_id=info:doi/10.1111/j.1365-2125.1984.tb02351.x&rft_dat=%3Cproquest_pubme%3E81022662%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81022662&rft_id=info:pmid/6712867&rfr_iscdi=true |