Epimorphin(-/-) mice have increased intestinal growth, decreased susceptibility to dextran sodium sulfate colitis, and impaired spermatogenesis

Dynamic and reciprocal epithelial-mesenchymal interactions are critical for the normal morphogenesis and maintenance of epithelia. Epimorphin has been identified as a unique molecule expressed by mesenchymal cells and myofibroblasts and has putative morphogenetic effects in multiple epithelial tissu...

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Veröffentlicht in:	The Journal of clinical investigation 2006-06, Vol.116 (6), p.1535-1546
Hauptverfasser:	Wang, Yuan, Wang, Lihua, Iordanov, Hristo, Swietlicki, Elzbieta A, Zheng, Qun, Jiang, Shujun, Tang, Yuzhu, Levin, Marc S, Rubin, Deborah C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - metabolism Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell Line Colitis - chemically induced Colitis - pathology Dextran Sulfate - toxicity Female Gene Targeting Indicators and Reagents - toxicity Intestines - cytology Intestines - growth & development Intestines - pathology Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, Nude Morphogenesis Spermatogenesis - physiology Testis - cytology Testis - pathology Testis - physiology Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Wnt Proteins - genetics Wnt Proteins - metabolism
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