Genetic Analysis of Caenorhabditis elegans glp-1 Mutants Suggests Receptor Interaction or Competition

glp-1 encodes a member of the highly conserved LIN-12/Notch family of receptors that mediates the mitosis/meiosis decision in the C. elegans germline. We have characterized three mutations that represent a new genetic and phenotypic class of glp-1 mutants, glp-1(Pro). The glp-1(Pro) mutants display...

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Veröffentlicht in:	Genetics (Austin) 2003-01, Vol.163 (1), p.115-132
Hauptverfasser:	Pepper, Anita S.-R, Killian, Darrell J, Hubbard, E. Jane Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - metabolism DNA-Binding Proteins - metabolism Genetic diversity Glucagon - genetics Glucagon - metabolism Glucagon-Like Peptide 1 Membrane Proteins - metabolism Mutation Peptide Fragments - genetics Peptide Fragments - metabolism Protein Precursors - genetics Protein Precursors - metabolism Receptors, Notch Signal Transduction - physiology
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