In Vivo Introduction of Unpreferred Synonymous Codons Into the Drosophila Adh Gene Results in Reduced Levels of ADH Protein

The evolution of codon bias, the unequal usage of synonymous codons, is thought to be due to natural selection for the use of preferred codons that match the most abundant species of isoaccepting tRNA, resulting in increased translational efficiency and accuracy. We examined this hypothesis by intro...

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Veröffentlicht in:	Genetics (Austin) 2003-01, Vol.163 (1), p.239-243
Hauptverfasser:	Carlini, David B, Stephan, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Dehydrogenase - genetics Alcohol Dehydrogenase - metabolism Analysis of Variance Animals Codon Drosophila - genetics Drosophila - metabolism Genes Genetic Code Proteins
Online-Zugang:	Volltext
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