Ectopic expression of the Drosophila Cdk1 inhibitory kinases, Wee1 and Myt1, interferes with the second mitotic wave and disrupts pattern formation during eye development

Wee1 kinases catalyze inhibitory phosphorylation of the mitotic regulator Cdk1, preventing mitosis during S phase and delaying it in response to DNA damage or developmental signals during G2. Unlike yeast, metazoans have two distinct Wee1-like kinases, a nuclear protein (Wee1) and a cytoplasmic prot...

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Veröffentlicht in:	Genetics (Austin) 2002-06, Vol.161 (2), p.721-731
Hauptverfasser:	Price, Donald M, Jin, Zhigang, Rabinovitch, Simon, Campbell, Shelagh D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cdk1 gene Cell Cycle Proteins - metabolism Drosophila Drosophila - embryology Drosophila - genetics Drosophila Proteins - genetics Drosophila Proteins - metabolism Enhancer Elements, Genetic Eye - embryology Genetic Vectors Mitosis - genetics Mitosis - physiology myt1 gene Nuclear Proteins Photoreceptor Cells, Invertebrate - embryology Protein Kinases - genetics Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Schizosaccharomyces pombe Proteins Sequence Deletion Tumor Suppressor Protein p53 - metabolism wee1 gene
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