The Acridine Ring Selectively Intercalated into a DNA Helix at Various Types of Abasic Sites: Double Strand Formation and Photophysical Properties

The interactions between the intercalating agent and the three types of abasic sites: abasic frameshift, apurinic and apyrimidinic, were investigated. 9-amino-6-chloro-2-methoxyacridine (ACMA), whose spectroscopic properties are strongly perturbed by the environment, was selected as the intercalatin...

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Veröffentlicht in:	Nucleic acids research 1996-10, Vol.24 (20), p.3962-3967
Hauptverfasser:	Fukui, Keijiro, Tanaka, Kazuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - metabolism Aminoacridines - metabolism Aminoacridines - pharmacology Chromatography, High Pressure Liquid DNA - chemistry DNA - metabolism DNA Adducts - chemistry DNA Adducts - metabolism Intercalating Agents - metabolism Kinetics Molecular Structure Nucleic Acid Conformation Nucleic Acid Denaturation Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Spectrometry, Fluorescence Spectrophotometry Temperature
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