Suppressor Analysis of a Histone Defect Identifies a New Function for the Hda1 Complex in Chromosome Segregation

Histones are essential for the compaction of DNA into chromatin and therefore participate in all chromosomal functions. Specific mutations in HTA1, one of the two Saccharomyces cerevisiae genes encoding histone H2A, have been previously shown to cause chromosome segregation defects, including an inc...

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Veröffentlicht in:	Genetics (Austin) 2006-05, Vol.173 (1), p.435-450
Hauptverfasser:	Kanta, Hasna, Laprade, Lisa, Almutairi, Abeer, Pinto, Ines
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Apoptosis Cell Cycle - genetics Chromatin Chromatin - genetics Chromosome Segregation - genetics Chromosomes Chromosomes, Fungal - genetics DNA, Fungal - genetics Fungal Proteins - genetics Gene Deletion Gene Expression Regulation, Fungal Genes, Fungal - genetics Genetics Histone Deacetylases - metabolism Histones - genetics Histones - metabolism Investigations Kinetochores Mutation - genetics Phenotype Ploidies Proteins RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - metabolism Suppression, Genetic - genetics
Online-Zugang:	Volltext
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