Effects of Prenatal Exposure to Polychlorinated Biphenyls and Dioxins on Mental and Motor Development in Japanese Children at 6 Months of Age
Several studies have shown that prenatal and/or postnatal background-level exposure to environmental chemicals, such as polychlorinated biphenyls (PCBs) and dioxins, induces adverse effects on the neurodevelopment of children. However, other studies have not detected any harmful influences on neurod...
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| Veröffentlicht in: | Environmental health perspectives 2006-05, Vol.114 (5), p.773-778 |
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| creator | Nakajima, Sonomi Saijo, Yasuaki Kato, Shizue Sasaki, Seiko Uno, Akiko Kanagami, Nobuo Hirakawa, Hironori Hori, Tsuguhide Tobiishi, Kazuhiro Todaka, Takashi Nakamura, Yuji Yanagiya, Satoko Sengoku, Yasuhito Iida, Takao Sata, Fumihiro Kishi, Reiko |
| description | Several studies have shown that prenatal and/or postnatal background-level exposure to environmental chemicals, such as polychlorinated biphenyls (PCBs) and dioxins, induces adverse effects on the neurodevelopment of children. However, other studies have not detected any harmful influences on neurodevelopment. Furthermore, except in western countries, no developmental tests have been carried out in relation to detailed assessment of exposure to PCBs and dioxins. In this study (the Hokkaido Study on Environment and Children's Health), the effect of prenatal exposure to background levels of PCBs and dioxins on infant neurodevelopment in Japan/Sapporo was elucidated. The associations between the total or individual isomer level of PCBs and dioxins in 134 Japanese pregnant women's peripheral blood and the mental or motor development of their 6-month-old infants were evaluated using the second edition of the Bayley Scales of Infant Development. The mean level of total toxicity equivalency quantity (TEQ) was 18.8 (4.0-51.2) pg/g lipid in blood of 134 mothers. After adjustment for potential confounding variables, the total TEQ value was shown not to be significantly associated with mental developmental index (MDI) or psychomotor developmental index (PDI). However, the levels of one polychlorinated dibenzo-p-dioxin (PCDD) isomer, total PCDDs, and total PCDDs/polychlorinated dibenzofurans (PCDFs) were significantly negatively associated with MDI, and the levels of two PCDD isomers and three PCDF isomers were significantly negatively associated with the PDI. In conclusion, the back-ground-level exposure of several isomers of dioxins during the prenatal period probably affects the motor development of 6-month-old infants more than it does their mental development. |
| doi_str_mv | 10.1289/ehp.8614 |
| format | Article |
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However, other studies have not detected any harmful influences on neurodevelopment. Furthermore, except in western countries, no developmental tests have been carried out in relation to detailed assessment of exposure to PCBs and dioxins. In this study (the Hokkaido Study on Environment and Children's Health), the effect of prenatal exposure to background levels of PCBs and dioxins on infant neurodevelopment in Japan/Sapporo was elucidated. The associations between the total or individual isomer level of PCBs and dioxins in 134 Japanese pregnant women's peripheral blood and the mental or motor development of their 6-month-old infants were evaluated using the second edition of the Bayley Scales of Infant Development. The mean level of total toxicity equivalency quantity (TEQ) was 18.8 (4.0-51.2) pg/g lipid in blood of 134 mothers. After adjustment for potential confounding variables, the total TEQ value was shown not to be significantly associated with mental developmental index (MDI) or psychomotor developmental index (PDI). However, the levels of one polychlorinated dibenzo-p-dioxin (PCDD) isomer, total PCDDs, and total PCDDs/polychlorinated dibenzofurans (PCDFs) were significantly negatively associated with MDI, and the levels of two PCDD isomers and three PCDF isomers were significantly negatively associated with the PDI. In conclusion, the back-ground-level exposure of several isomers of dioxins during the prenatal period probably affects the motor development of 6-month-old infants more than it does their mental development.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.8614</identifier><identifier>PMID: 16675436</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences. 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Department of Health, Education and Welfare</publisher><subject>Air pollution ; Analysis ; Blood ; Child development ; Children ; Children's Health ; Congeners ; Dioxins ; Dioxins - toxicity ; Female ; Gas Chromatography-Mass Spectrometry - methods ; Health aspects ; Humans ; Infant ; Infants ; Isomers ; Japan ; Motor Activity - drug effects ; Motor development ; Nervous System - drug effects ; Nervous System - growth & development ; Polychlorinated biphenyls ; Polychlorinated Biphenyls - toxicity ; Pregnancy ; Pregnant women ; Prenatal exposure ; Prenatal Exposure Delayed Effects ; School age children</subject><ispartof>Environmental health perspectives, 2006-05, Vol.114 (5), p.773-778</ispartof><rights>COPYRIGHT 2006 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences May 2006</rights><rights>2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c784t-b0ae18c5dbb13e782c8c655e8a26bffe78fd045d0114d0067984ebb0491440833</citedby><cites>FETCH-LOGICAL-c784t-b0ae18c5dbb13e782c8c655e8a26bffe78fd045d0114d0067984ebb0491440833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3651053$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3651053$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27903,27904,53769,53771,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16675436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakajima, Sonomi</creatorcontrib><creatorcontrib>Saijo, Yasuaki</creatorcontrib><creatorcontrib>Kato, Shizue</creatorcontrib><creatorcontrib>Sasaki, Seiko</creatorcontrib><creatorcontrib>Uno, Akiko</creatorcontrib><creatorcontrib>Kanagami, Nobuo</creatorcontrib><creatorcontrib>Hirakawa, Hironori</creatorcontrib><creatorcontrib>Hori, Tsuguhide</creatorcontrib><creatorcontrib>Tobiishi, Kazuhiro</creatorcontrib><creatorcontrib>Todaka, Takashi</creatorcontrib><creatorcontrib>Nakamura, Yuji</creatorcontrib><creatorcontrib>Yanagiya, Satoko</creatorcontrib><creatorcontrib>Sengoku, Yasuhito</creatorcontrib><creatorcontrib>Iida, Takao</creatorcontrib><creatorcontrib>Sata, Fumihiro</creatorcontrib><creatorcontrib>Kishi, Reiko</creatorcontrib><title>Effects of Prenatal Exposure to Polychlorinated Biphenyls and Dioxins on Mental and Motor Development in Japanese Children at 6 Months of Age</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Several studies have shown that prenatal and/or postnatal background-level exposure to environmental chemicals, such as polychlorinated biphenyls (PCBs) and dioxins, induces adverse effects on the neurodevelopment of children. 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perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>114</volume><issue>5</issue><spage>773</spage><epage>778</epage><pages>773-778</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Several studies have shown that prenatal and/or postnatal background-level exposure to environmental chemicals, such as polychlorinated biphenyls (PCBs) and dioxins, induces adverse effects on the neurodevelopment of children. 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After adjustment for potential confounding variables, the total TEQ value was shown not to be significantly associated with mental developmental index (MDI) or psychomotor developmental index (PDI). However, the levels of one polychlorinated dibenzo-p-dioxin (PCDD) isomer, total PCDDs, and total PCDDs/polychlorinated dibenzofurans (PCDFs) were significantly negatively associated with MDI, and the levels of two PCDD isomers and three PCDF isomers were significantly negatively associated with the PDI. In conclusion, the back-ground-level exposure of several isomers of dioxins during the prenatal period probably affects the motor development of 6-month-old infants more than it does their mental development.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences. National Institutes of Health. Department of Health, Education and Welfare</pub><pmid>16675436</pmid><doi>10.1289/ehp.8614</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2006-05, Vol.114 (5), p.773-778 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1459935 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Jstor Complete Legacy; PubMed Central |
| subjects | Air pollution Analysis Blood Child development Children Children's Health Congeners Dioxins Dioxins - toxicity Female Gas Chromatography-Mass Spectrometry - methods Health aspects Humans Infant Infants Isomers Japan Motor Activity - drug effects Motor development Nervous System - drug effects Nervous System - growth & development Polychlorinated biphenyls Polychlorinated Biphenyls - toxicity Pregnancy Pregnant women Prenatal exposure Prenatal Exposure Delayed Effects School age children |
| title | Effects of Prenatal Exposure to Polychlorinated Biphenyls and Dioxins on Mental and Motor Development in Japanese Children at 6 Months of Age |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T22%3A41%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Prenatal%20Exposure%20to%20Polychlorinated%20Biphenyls%20and%20Dioxins%20on%20Mental%20and%20Motor%20Development%20in%20Japanese%20Children%20at%206%20Months%20of%20Age&rft.jtitle=Environmental%20health%20perspectives&rft.au=Nakajima,%20Sonomi&rft.date=2006-05-01&rft.volume=114&rft.issue=5&rft.spage=773&rft.epage=778&rft.pages=773-778&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/ehp.8614&rft_dat=%3Cgale_pubme%3EA158523322%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=222620532&rft_id=info:pmid/16675436&rft_galeid=A158523322&rft_jstor_id=3651053&rfr_iscdi=true |