Sulfates Dramatically Stabilize a Salt-Dependent Type of Glucagon Fibrils

Recent work suggests that protein fibrillation mechanisms and the structure of the resulting protein fibrils are very sensitive to environmental conditions such as temperature and ionic strength. Here we report the effect of several inorganic salts on the fibrillation of glucagon. At acidic pH, fibr...

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Veröffentlicht in:	Biophysical journal 2006-06, Vol.90 (11), p.4181-4194
Hauptverfasser:	Pedersen, Jesper Søndergaard, Flink, James M., Dikov, Dantcho, Otzen, Daniel Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Anions - chemistry Cations - chemistry Glucagon - chemistry Hydrogen-Ion Concentration Microscopy Microscopy, Fluorescence Models, Biological Protein folding Proteins Salt Salts - chemistry Sodium Chloride - chemistry Solubility Sulfates - chemistry Surface tension
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