G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription

In human and mouse, the promoter of the KRAS gene contains a nuclease hypersensitive polypurine–polypyrimidine element (NHPPE) that is essential for transcription. An interesting feature of the polypurine G-rich strand of NHPPE is its ability to assume an unusual DNA structure that, according to cir...

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Veröffentlicht in:	Nucleic acids research 2006-01, Vol.34 (9), p.2536-2549
Hauptverfasser:	Cogoi, Susanna, Xodo, Luigi E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites Cell Line DNA - chemistry DNA Footprinting DNA-Directed DNA Polymerase - metabolism G-Quadruplexes Gene Expression Regulation Genes, ras Guanine - chemistry Humans Mice Molecular Sequence Data Nuclear Proteins - metabolism Porphyrins - chemistry Promoter Regions, Genetic Purines - chemistry Pyrimidines - chemistry Transcription, Genetic
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