Glucocorticoid Enhancement of Memory Requires Arousal-Induced Noradrenergic Activation in the Basolateral Amygdala

Considerable evidence indicates that glucocorticoid hormones enhance the consolidation of long-term memories for emotionally arousing experiences but not that for less arousing or neutral information. However, previous studies have not determined the basis of such arousal-induced selectivity. Here w...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-04, Vol.103 (17), p.6741-6746
Hauptverfasser:	Roozendaal, Benno, Okuda, Shoki, Van der Zee, Eddy A., McGaugh, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology Amygdala Amygdala - anatomy & histology Amygdala - drug effects Amygdala - physiology Animals Arousal - drug effects Arousal - physiology Behavioral neuroscience Biological Sciences Brain Corticosterone Corticosterone - pharmacology Cyclic AMP Response Element-Binding Protein - chemistry Cyclic AMP Response Element-Binding Protein - metabolism Glucocorticoids Habituation Habituation, Psychophysiologic - physiology Hippocampus Hormones Male Memory Memory - drug effects Memory - physiology Neurosciences Norepinephrine Norepinephrine - physiology Object recognition Phosphorylation Propranolol - pharmacology Rats Rats, Sprague-Dawley Rodents Vehicles Yohimbine - pharmacology
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