Functional heterogeneity of macrophages
The antibody-binding activities of rabbit peritoneal macrophages separated on discontinuous gradients of Ficoll were investigated. The antibody was rabbit anti-ovalbumin IgG labelled with 125I. Of the five fractions obtained, one macrophage fraction was found to bind substantially more antibody than...
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| Veröffentlicht in: | Immunology 1979-04, Vol.36 (4), p.729-732 |
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| container_title | Immunology |
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| creator | Kávai, M Laczkó, J Csaba, B |
| description | The antibody-binding activities of rabbit peritoneal macrophages separated on discontinuous gradients of Ficoll were investigated. The antibody was rabbit anti-ovalbumin IgG labelled with 125I. Of the five fractions obtained, one macrophage fraction was found to bind substantially more antibody than the others. These macrophages possessed more Fc receptor sites than the others and the number of Fc receptors (n) and the association constant (K) of these cells was calculated. By electron microscopy, the phagocytic activity of the subpopulation with most Fc receptors was less than that of the others. |
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The antibody was rabbit anti-ovalbumin IgG labelled with 125I. Of the five fractions obtained, one macrophage fraction was found to bind substantially more antibody than the others. These macrophages possessed more Fc receptor sites than the others and the number of Fc receptors (n) and the association constant (K) of these cells was calculated. By electron microscopy, the phagocytic activity of the subpopulation with most Fc receptors was less than that of the others.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>PMID: 437846</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Cell Membrane - immunology ; Cell Separation ; Female ; Immunoglobulin Fc Fragments - immunology ; Immunoglobulin G - immunology ; Macrophages - immunology ; Macrophages - ultrastructure ; Male ; Microscopy, Electron ; Rabbits</subject><ispartof>Immunology, 1979-04, Vol.36 (4), p.729-732</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457648/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457648/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/437846$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kávai, M</creatorcontrib><creatorcontrib>Laczkó, J</creatorcontrib><creatorcontrib>Csaba, B</creatorcontrib><title>Functional heterogeneity of macrophages</title><title>Immunology</title><addtitle>Immunology</addtitle><description>The antibody-binding activities of rabbit peritoneal macrophages separated on discontinuous gradients of Ficoll were investigated. The antibody was rabbit anti-ovalbumin IgG labelled with 125I. Of the five fractions obtained, one macrophage fraction was found to bind substantially more antibody than the others. These macrophages possessed more Fc receptor sites than the others and the number of Fc receptors (n) and the association constant (K) of these cells was calculated. By electron microscopy, the phagocytic activity of the subpopulation with most Fc receptors was less than that of the others.</description><subject>Animals</subject><subject>Cell Membrane - immunology</subject><subject>Cell Separation</subject><subject>Female</subject><subject>Immunoglobulin Fc Fragments - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - ultrastructure</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Rabbits</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLw0AUhQfxVaP_wEVXugrM484jG0GKVaHgRtfDZHKnjSSZmEmE_nsDLaKrw-HA98E5IQsmlMy5VPqULChlRc4NlZfkKqXPuQoq5QU5B6ENqAW5X0-dH-vYuWa5wxGHuMUO63G_jGHZOj_Efue2mK7JWXBNwptjZuRj_fS-esk3b8-vq8dN3nNFx1xWBRRaax90gMIHUYCZg1fGYKAaTRCegwHGBeeClsrIkoFWCMJVJVMiIw8Hbj-VLVYeu3Fwje2HunXD3kZX2_9LV-_sNn5bBlIrMDPg7ggY4teEabRtnTw2jeswTslqkMD0LM_I7V_Tr-LwjPgB6Ixgbw</recordid><startdate>19790401</startdate><enddate>19790401</enddate><creator>Kávai, M</creator><creator>Laczkó, J</creator><creator>Csaba, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19790401</creationdate><title>Functional heterogeneity of macrophages</title><author>Kávai, M ; Laczkó, J ; Csaba, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p260t-5d949777cf7f49cf39489cf2d88ef07e8f3c24841232230b685b1476e43adb163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Cell Membrane - immunology</topic><topic>Cell Separation</topic><topic>Female</topic><topic>Immunoglobulin Fc Fragments - immunology</topic><topic>Immunoglobulin G - immunology</topic><topic>Macrophages - immunology</topic><topic>Macrophages - ultrastructure</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kávai, M</creatorcontrib><creatorcontrib>Laczkó, J</creatorcontrib><creatorcontrib>Csaba, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kávai, M</au><au>Laczkó, J</au><au>Csaba, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional heterogeneity of macrophages</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1979-04-01</date><risdate>1979</risdate><volume>36</volume><issue>4</issue><spage>729</spage><epage>732</epage><pages>729-732</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>The antibody-binding activities of rabbit peritoneal macrophages separated on discontinuous gradients of Ficoll were investigated. The antibody was rabbit anti-ovalbumin IgG labelled with 125I. Of the five fractions obtained, one macrophage fraction was found to bind substantially more antibody than the others. These macrophages possessed more Fc receptor sites than the others and the number of Fc receptors (n) and the association constant (K) of these cells was calculated. By electron microscopy, the phagocytic activity of the subpopulation with most Fc receptors was less than that of the others.</abstract><cop>England</cop><pmid>437846</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Immunology, 1979-04, Vol.36 (4), p.729-732 |
| issn | 0019-2805 1365-2567 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1457648 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Cell Membrane - immunology Cell Separation Female Immunoglobulin Fc Fragments - immunology Immunoglobulin G - immunology Macrophages - immunology Macrophages - ultrastructure Male Microscopy, Electron Rabbits |
| title | Functional heterogeneity of macrophages |
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