Immune responses in mice infected with lactic dehydrogenase virus. IV. Functional status of the macrophage during acute LDV infection
Macrophages from uninfected and lactic dehydrogenase virus (LDV)-infected mice were compared with respect to the affinity and number of their Fc receptors for IgG2a; no differences were found regarding these parameters. When the uptake of DNP-BGG by macrophages from uninfected and acutely LDV-infect...
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| Veröffentlicht in: | Immunology 1979-02, Vol.36 (2), p.241-246 |
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| creator | Michaelides, M C Simms, E S |
| description | Macrophages from uninfected and lactic dehydrogenase virus (LDV)-infected mice were compared with respect to the affinity and number of their Fc receptors for IgG2a; no differences were found regarding these parameters. When the uptake of DNP-BGG by macrophages from uninfected and acutely LDV-infected mice was compared, again no differences were observed. However, when the per cent membrane-bound DNP-BGG was determined as a function of time after antigen uptake in these two groups, more DNP-BGG was found membrane-bound on the macrophages from the LDV-infected mice, than on uninfected macrophages. In view of the fact that humoral immunity is enhanced during acute LDV infection, these data provide a positive correlation between increased retention of membrane-bound antigen and enhanced humoral immune responses. |
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IV. Functional status of the macrophage during acute LDV infection</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Michaelides, M C ; Simms, E S</creator><creatorcontrib>Michaelides, M C ; Simms, E S</creatorcontrib><description>Macrophages from uninfected and lactic dehydrogenase virus (LDV)-infected mice were compared with respect to the affinity and number of their Fc receptors for IgG2a; no differences were found regarding these parameters. When the uptake of DNP-BGG by macrophages from uninfected and acutely LDV-infected mice was compared, again no differences were observed. However, when the per cent membrane-bound DNP-BGG was determined as a function of time after antigen uptake in these two groups, more DNP-BGG was found membrane-bound on the macrophages from the LDV-infected mice, than on uninfected macrophages. In view of the fact that humoral immunity is enhanced during acute LDV infection, these data provide a positive correlation between increased retention of membrane-bound antigen and enhanced humoral immune responses.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>PMID: 86506</identifier><language>eng</language><publisher>England</publisher><subject>Acute Disease ; Animals ; Antibodies, Viral - biosynthesis ; Antigens ; Binding Sites ; Cell Membrane - immunology ; Dinitrobenzenes - immunology ; Female ; gamma-Globulins - immunology ; Immunoglobulin Fc Fragments - immunology ; Immunoglobulin G - immunology ; Lactate dehydrogenase-elevating virus - immunology ; Macrophages - immunology ; Macrophages - metabolism ; Mice ; Mice, Inbred BALB C ; Virus Diseases - immunology</subject><ispartof>Immunology, 1979-02, Vol.36 (2), p.241-246</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457474/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457474/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/86506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Michaelides, M C</creatorcontrib><creatorcontrib>Simms, E S</creatorcontrib><title>Immune responses in mice infected with lactic dehydrogenase virus. IV. Functional status of the macrophage during acute LDV infection</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Macrophages from uninfected and lactic dehydrogenase virus (LDV)-infected mice were compared with respect to the affinity and number of their Fc receptors for IgG2a; no differences were found regarding these parameters. When the uptake of DNP-BGG by macrophages from uninfected and acutely LDV-infected mice was compared, again no differences were observed. However, when the per cent membrane-bound DNP-BGG was determined as a function of time after antigen uptake in these two groups, more DNP-BGG was found membrane-bound on the macrophages from the LDV-infected mice, than on uninfected macrophages. In view of the fact that humoral immunity is enhanced during acute LDV infection, these data provide a positive correlation between increased retention of membrane-bound antigen and enhanced humoral immune responses.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antigens</subject><subject>Binding Sites</subject><subject>Cell Membrane - immunology</subject><subject>Dinitrobenzenes - immunology</subject><subject>Female</subject><subject>gamma-Globulins - immunology</subject><subject>Immunoglobulin Fc Fragments - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>Lactate dehydrogenase-elevating virus - immunology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Virus Diseases - immunology</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM1KxDAUhYs46Dj6BG6ycldJ06Q_G0FGRwcG3Kjbck1up5E2qfkZ8QF8b4sOoqvD5Z7zHTgHyTzLC5EyUZSHyZzSrE5ZRcVxcuL963TmVIijZFYVghbz5HM9DNEgcehHazx6og0ZtMRJW5QBFXnXoSM9yKAlUdh9KGe3aMAj2WkX_SVZP1-SVTSTwRroiQ8Qoie2JaFDMoB0duxgi0RFp82WgIwByebmeV8xpU6TWQu9x7O9LpKn1e3j8j7dPNytl9ebdMxKHlLGgWOZyZwVtayZEgKQFlQBzwvWAuNcSEWhfVFtxkUrKg5ZxeoyyxnLqczyRXL1wx3jy4BKogkO-mZ0egD30VjQzf-P0V2ztbtmwpW85BPgYg9w9i2iD82gvcS-B4M2-qbkvKqnYSfj-d-m34rv2fMvF2eCLw</recordid><startdate>19790201</startdate><enddate>19790201</enddate><creator>Michaelides, M C</creator><creator>Simms, E S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19790201</creationdate><title>Immune responses in mice infected with lactic dehydrogenase virus. 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IV. Functional status of the macrophage during acute LDV infection</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1979-02-01</date><risdate>1979</risdate><volume>36</volume><issue>2</issue><spage>241</spage><epage>246</epage><pages>241-246</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Macrophages from uninfected and lactic dehydrogenase virus (LDV)-infected mice were compared with respect to the affinity and number of their Fc receptors for IgG2a; no differences were found regarding these parameters. When the uptake of DNP-BGG by macrophages from uninfected and acutely LDV-infected mice was compared, again no differences were observed. However, when the per cent membrane-bound DNP-BGG was determined as a function of time after antigen uptake in these two groups, more DNP-BGG was found membrane-bound on the macrophages from the LDV-infected mice, than on uninfected macrophages. 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| ispartof | Immunology, 1979-02, Vol.36 (2), p.241-246 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acute Disease Animals Antibodies, Viral - biosynthesis Antigens Binding Sites Cell Membrane - immunology Dinitrobenzenes - immunology Female gamma-Globulins - immunology Immunoglobulin Fc Fragments - immunology Immunoglobulin G - immunology Lactate dehydrogenase-elevating virus - immunology Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred BALB C Virus Diseases - immunology |
| title | Immune responses in mice infected with lactic dehydrogenase virus. IV. Functional status of the macrophage during acute LDV infection |
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