A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome

8-Oxoguanine (8-oxoG), a major spontaneous form of oxidative DNA damage, is considered to be a natural cause of genomic diversity in organisms because of its mutagenic potential. The steady-state level of 8-oxoG in the nuclear genome of a human cell has been estimated to be several residues per 10(6...

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Veröffentlicht in:	Genome Research 2006-05, Vol.16 (5), p.567-575
Hauptverfasser:	Ohno, Mizuki, Miura, Tomofumi, Furuichi, Masato, Tominaga, Yohei, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Nakabeppu, Yusaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 11 - genetics DNA Damage Female Genome, Human Guanine - analogs & derivatives Guanine - analysis Humans In Situ Hybridization, Fluorescence Male Polymorphism, Single Nucleotide Recombination, Genetic
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