The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

Misfolded proteins of the endoplasmic reticulum (ER) are targeted to the cytoplasm for proteasomal degradation. Key components of this process are ER membrane‐bound ubiquitin ligases. These ligases associate with the cytoplasmic AAA‐ATPase Cdc48p/p97, which is thought to support the release of malfo...

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Veröffentlicht in:	The EMBO journal 2006-05, Vol.25 (9), p.1827-1835
Hauptverfasser:	Gauss, Robert, Sommer, Thomas, Jarosch, Ernst
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Catalysis Cdc48/p97 Cell Cycle Proteins - metabolism EMBO20 EMBO31 Endoplasmic Reticulum - enzymology Enzymes ERAD Hrd1 Hrd3 Membrane Glycoproteins - metabolism Membrane Proteins - metabolism Membranes protein degradation Protein Folding Proteins Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - metabolism Substrate Specificity Substrates Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-Protein Ligases - metabolism Valosin Containing Protein Yeast Yeasts
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