Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila melanogaster
Previously we described highly unstable mutations in the yellow locus, induced by the chimeric element and consisting of sequences from a distally located 1A unique genomic region, flanked by identical copies of an internally deleted 1.2-kb P element. Here we show that a sequence, which is part of t...
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| Veröffentlicht in: | Genetics (Austin) 2006-04, Vol.172 (4), p.2283-2291 |
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| creator | Pomerantseva, Ekaterina Biryukova, Inna Silicheva, Rita Savitskaya, Ekaterina Golovnin, Anton Georgiev, Pavel |
| description | Previously we described highly unstable mutations in the yellow locus, induced by the chimeric element and consisting of sequences from a distally located 1A unique genomic region, flanked by identical copies of an internally deleted 1.2-kb P element. Here we show that a sequence, which is part of the yellow 1A region, can be transmitted to the AS-C by successive inversion and reinversion generated by yellow- and AS-C-located P elements. The chimeric element contains a regulatory element from the 1A region that specifically blocks yellow wing and body enhancers and simultaneously stimulates yellow expression in bristles. These results suggest that P-element-generated chimeric elements may play a certain role in rapid changes of regulatory regions of genes during evolution. |
| doi_str_mv | 10.1534/genetics.105.052803 |
| format | Article |
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Here we show that a sequence, which is part of the yellow 1A region, can be transmitted to the AS-C by successive inversion and reinversion generated by yellow- and AS-C-located P elements. The chimeric element contains a regulatory element from the 1A region that specifically blocks yellow wing and body enhancers and simultaneously stimulates yellow expression in bristles. These results suggest that P-element-generated chimeric elements may play a certain role in rapid changes of regulatory regions of genes during evolution.</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1534/genetics.105.052803</identifier><identifier>PMID: 16387869</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>United States: Genetics Soc America</publisher><subject>Alleles ; Animals ; Deoxyribonucleic acid ; DNA ; DNA - metabolism ; DNA Transposable Elements ; Drosophila melanogaster ; Drosophila melanogaster - genetics ; Enhancer Elements, Genetic ; Evolution, Molecular ; Genes ; Genetics ; Germ-Line Mutation ; Insect Proteins ; Investigations ; Life Sciences ; Models, Genetic ; Mutagenesis, Insertional ; Phenotype ; Recombinant Fusion Proteins - chemistry ; Regulatory Sequences, Nucleic Acid ; Restriction Mapping</subject><ispartof>Genetics (Austin), 2006-04, Vol.172 (4), p.2283-2291</ispartof><rights>Copyright Genetics Society of America Apr 2006</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2006 by the Genetics Society of America 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-d1318059196a59aa3ab39f447c3fbf65959bd22b107a073812c6caac9be5c0dc3</citedby><cites>FETCH-LOGICAL-c558t-d1318059196a59aa3ab39f447c3fbf65959bd22b107a073812c6caac9be5c0dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16387869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-04120033$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pomerantseva, Ekaterina</creatorcontrib><creatorcontrib>Biryukova, Inna</creatorcontrib><creatorcontrib>Silicheva, Rita</creatorcontrib><creatorcontrib>Savitskaya, Ekaterina</creatorcontrib><creatorcontrib>Golovnin, Anton</creatorcontrib><creatorcontrib>Georgiev, Pavel</creatorcontrib><title>Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila melanogaster</title><title>Genetics (Austin)</title><addtitle>Genetics</addtitle><description>Previously we described highly unstable mutations in the yellow locus, induced by the chimeric element and consisting of sequences from a distally located 1A unique genomic region, flanked by identical copies of an internally deleted 1.2-kb P element. Here we show that a sequence, which is part of the yellow 1A region, can be transmitted to the AS-C by successive inversion and reinversion generated by yellow- and AS-C-located P elements. The chimeric element contains a regulatory element from the 1A region that specifically blocks yellow wing and body enhancers and simultaneously stimulates yellow expression in bristles. These results suggest that P-element-generated chimeric elements may play a certain role in rapid changes of regulatory regions of genes during evolution.</description><subject>Alleles</subject><subject>Animals</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - metabolism</subject><subject>DNA Transposable Elements</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - genetics</subject><subject>Enhancer Elements, Genetic</subject><subject>Evolution, Molecular</subject><subject>Genes</subject><subject>Genetics</subject><subject>Germ-Line Mutation</subject><subject>Insect Proteins</subject><subject>Investigations</subject><subject>Life Sciences</subject><subject>Models, Genetic</subject><subject>Mutagenesis, Insertional</subject><subject>Phenotype</subject><subject>Recombinant Fusion Proteins - chemistry</subject><subject>Regulatory Sequences, Nucleic Acid</subject><subject>Restriction 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| ispartof | Genetics (Austin), 2006-04, Vol.172 (4), p.2283-2291 |
| issn | 0016-6731 1943-2631 1943-2631 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alleles Animals Deoxyribonucleic acid DNA DNA - metabolism DNA Transposable Elements Drosophila melanogaster Drosophila melanogaster - genetics Enhancer Elements, Genetic Evolution, Molecular Genes Genetics Germ-Line Mutation Insect Proteins Investigations Life Sciences Models, Genetic Mutagenesis, Insertional Phenotype Recombinant Fusion Proteins - chemistry Regulatory Sequences, Nucleic Acid Restriction Mapping |
| title | Transposition of Regulatory Elements by P-Element-Mediated Rearrangements in Drosophila melanogaster |
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