The Role of Selection in the Evolution of Human Mitochondrial Genomes

High mutation rate in mammalian mitochondrial DNA generates a highly divergent pool of alleles even within species that have dispersed and expanded in size recently. Phylogenetic analysis of 277 human mitochondrial genomes revealed a significant (P < 0.01) excess of rRNA and nonsynonymous base su...

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Veröffentlicht in:	Genetics (Austin) 2006-01, Vol.172 (1), p.373-387
Hauptverfasser:	Kivisild, Toomas, Shen, Peidong, Wall, Dennis P, Do, Bao, Sung, Raphael, Davis, Karen, Passarino, Giuseppe, Underhill, Peter A, Scharfe, Curt, Torroni, Antonio, Scozzari, Rosaria, Modiano, David, Coppa, Alfredo, de Knijff, Peter, Feldman, Marcus, Cavalli-Sforza, Luca L, Oefner, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Base Pairing Base Sequence Codon - genetics Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Evolution, Molecular Genetics Genome, Human Humans Investigations Mitochondria - genetics Mitochondrial DNA Molecular Sequence Data Mutation - genetics Phylogeny Proteins RNA, Ribosomal - genetics Samples Selection, Genetic
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