Synthetic sulpholipopolysaccharides: novel adjuvants for humoral immune responses

Referring to the strong immunostimulating activity of combinations of lipophilic agents and dextran sulphate, conjugates with chemical determinants of both types of adjuvants were synthesized and then examined for immunostimulatory capabilities in mice. Saturated fatty acids with varying chain lengt...

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Veröffentlicht in:	Immunology 1987, Vol.60 (1), p.141-146
Hauptverfasser:	HILGERS, L. A. T, SNIPPE, H, JANSZE, M, WILLERS, J. M. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Animals Antibody Formation Biological and medical sciences Dinitrophenols - immunology Dose-Response Relationship, Immunologic Female Fundamental and applied biological sciences. Psychology Fundamental immunology Hemolytic Plaque Technique Immunobiology Lipids - immunology Lipopolysaccharides - biosynthesis Lipopolysaccharides - immunology Mice Mice, Inbred BALB C Modulation of the immune response (stimulation, suppression) Palmitates - immunology Polysaccharides - biosynthesis Polysaccharides - immunology Serum Albumin, Bovine - immunology Structure-Activity Relationship Sulfates - immunology
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