Repeated antigenic stimulation overcomes immunosuppression in experimental chagas' disease
Mice infected with Trypanosoma cruzi, and profoundly suppressed in their ability to respond to sheep erythrocytes (SRBC), were found to become highly responsive to these antigens when given two injections of SRBC at 4- or 6-day intervals. Two injections at intervals of 2, 8 or 10 days did not restor...
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| Veröffentlicht in: | Immunology 1986-10, Vol.59 (2), p.289-294 |
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| container_title | Immunology |
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| creator | CHOROMANSKI, L KUHN, R. E |
| description | Mice infected with Trypanosoma cruzi, and profoundly suppressed in their ability to respond to sheep erythrocytes (SRBC), were found to become highly responsive to these antigens when given two injections of SRBC at 4- or 6-day intervals. Two injections at intervals of 2, 8 or 10 days did not restore responsiveness. The ability to overcome immunosuppression via two challenges with antigen was found to be antigen-specific, in that if the first injection was with SRBC and the second with horse RBC there was no enhancement of plaque-forming cells to either antigen. Homologous challenges with SRBC or HRBC, however, did overcome immunosuppression. It is suggested that the ability to overcome immunosuppression by two injections of antigens at 4- or 6-day intervals is due to stimulation of a small number of T-helper cells in the first injection and an expansion of these cells in the second injection resulting in sufficient help to induce specific B-cell responses. |
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E</creator><creatorcontrib>CHOROMANSKI, L ; KUHN, R. E</creatorcontrib><description>Mice infected with Trypanosoma cruzi, and profoundly suppressed in their ability to respond to sheep erythrocytes (SRBC), were found to become highly responsive to these antigens when given two injections of SRBC at 4- or 6-day intervals. Two injections at intervals of 2, 8 or 10 days did not restore responsiveness. The ability to overcome immunosuppression via two challenges with antigen was found to be antigen-specific, in that if the first injection was with SRBC and the second with horse RBC there was no enhancement of plaque-forming cells to either antigen. Homologous challenges with SRBC or HRBC, however, did overcome immunosuppression. It is suggested that the ability to overcome immunosuppression by two injections of antigens at 4- or 6-day intervals is due to stimulation of a small number of T-helper cells in the first injection and an expansion of these cells in the second injection resulting in sufficient help to induce specific B-cell responses.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>PMID: 2429922</identifier><identifier>CODEN: IMMUAM</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Antigens, Protozoan - immunology ; Applied sciences ; Chagas Disease - immunology ; Dose-Response Relationship, Immunologic ; Epitopes - immunology ; Erythrocytes - immunology ; Exact sciences and technology ; Female ; Hemolytic Plaque Technique ; Horses - immunology ; Immune Tolerance ; Mice ; Mice, Inbred C57BL ; Other techniques and industries ; Sheep - immunology ; Time Factors ; Trypanosoma cruzi</subject><ispartof>Immunology, 1986-10, Vol.59 (2), p.289-294</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1453176/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1453176/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8349172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2429922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHOROMANSKI, L</creatorcontrib><creatorcontrib>KUHN, R. E</creatorcontrib><title>Repeated antigenic stimulation overcomes immunosuppression in experimental chagas' disease</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Mice infected with Trypanosoma cruzi, and profoundly suppressed in their ability to respond to sheep erythrocytes (SRBC), were found to become highly responsive to these antigens when given two injections of SRBC at 4- or 6-day intervals. Two injections at intervals of 2, 8 or 10 days did not restore responsiveness. The ability to overcome immunosuppression via two challenges with antigen was found to be antigen-specific, in that if the first injection was with SRBC and the second with horse RBC there was no enhancement of plaque-forming cells to either antigen. Homologous challenges with SRBC or HRBC, however, did overcome immunosuppression. It is suggested that the ability to overcome immunosuppression by two injections of antigens at 4- or 6-day intervals is due to stimulation of a small number of T-helper cells in the first injection and an expansion of these cells in the second injection resulting in sufficient help to induce specific B-cell responses.</description><subject>Animals</subject><subject>Antigens, Protozoan - immunology</subject><subject>Applied sciences</subject><subject>Chagas Disease - immunology</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Epitopes - immunology</subject><subject>Erythrocytes - immunology</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Hemolytic Plaque Technique</subject><subject>Horses - immunology</subject><subject>Immune Tolerance</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Other techniques and industries</subject><subject>Sheep - immunology</subject><subject>Time Factors</subject><subject>Trypanosoma cruzi</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRaq3-BCEH0VNgP7LZ5CJI8QsKgujFS5huJu1KshszSdF_b4ql6MnTMDwvL8_MAZsKlepY6tQcsinnIo9lxvUxOyF6H1fFtZ6wiUxknks5ZW_P2CL0WEbge7dC72xEvWuGGnoXfBQ22NnQIEWuaQYfaGjbDom2zPkIP1vsXIO-hzqya1gBXUWlIwTCU3ZUQU14tpsz9np3-zJ_iBdP94_zm0XcKin6OAVlbG5Sq3SeCW0BeVYmS1CiAlQJKADBUZRZBRKs4FYlRmzv4FxWMs3VjF3_9LbDssHSjjId1EU7ekH3VQRwxV_i3bpYhU0hEq2ESceCy11BFz4GpL5oHFmsa_AYBiqMEVxlJvk3OBZmidFiDJ7_Vtq77N4-8osdB7JQVx1462gfy1SSCyPVNyXCjt0</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>CHOROMANSKI, L</creator><creator>KUHN, R. E</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19861001</creationdate><title>Repeated antigenic stimulation overcomes immunosuppression in experimental chagas' disease</title><author>CHOROMANSKI, L ; KUHN, R. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p321t-6a37c976c359815cae08d4ba31fae34a3aa10e1d8fa2ac10c34711305002f2693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Antigens, Protozoan - immunology</topic><topic>Applied sciences</topic><topic>Chagas Disease - immunology</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Epitopes - immunology</topic><topic>Erythrocytes - immunology</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>Hemolytic Plaque Technique</topic><topic>Horses - immunology</topic><topic>Immune Tolerance</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Other techniques and industries</topic><topic>Sheep - immunology</topic><topic>Time Factors</topic><topic>Trypanosoma cruzi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHOROMANSKI, L</creatorcontrib><creatorcontrib>KUHN, R. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHOROMANSKI, L</au><au>KUHN, R. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repeated antigenic stimulation overcomes immunosuppression in experimental chagas' disease</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1986-10-01</date><risdate>1986</risdate><volume>59</volume><issue>2</issue><spage>289</spage><epage>294</epage><pages>289-294</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><coden>IMMUAM</coden><abstract>Mice infected with Trypanosoma cruzi, and profoundly suppressed in their ability to respond to sheep erythrocytes (SRBC), were found to become highly responsive to these antigens when given two injections of SRBC at 4- or 6-day intervals. Two injections at intervals of 2, 8 or 10 days did not restore responsiveness. The ability to overcome immunosuppression via two challenges with antigen was found to be antigen-specific, in that if the first injection was with SRBC and the second with horse RBC there was no enhancement of plaque-forming cells to either antigen. Homologous challenges with SRBC or HRBC, however, did overcome immunosuppression. It is suggested that the ability to overcome immunosuppression by two injections of antigens at 4- or 6-day intervals is due to stimulation of a small number of T-helper cells in the first injection and an expansion of these cells in the second injection resulting in sufficient help to induce specific B-cell responses.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>2429922</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Immunology, 1986-10, Vol.59 (2), p.289-294 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Antigens, Protozoan - immunology Applied sciences Chagas Disease - immunology Dose-Response Relationship, Immunologic Epitopes - immunology Erythrocytes - immunology Exact sciences and technology Female Hemolytic Plaque Technique Horses - immunology Immune Tolerance Mice Mice, Inbred C57BL Other techniques and industries Sheep - immunology Time Factors Trypanosoma cruzi |
| title | Repeated antigenic stimulation overcomes immunosuppression in experimental chagas' disease |
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