A rat model of purine nucleoside phosphorylase deficiency

Purine nucleoside phosphorylase (NP; EC 2.4.2.1) deficiency is associated with selective T-cell dysfunction and normal B-cell immunity. In order to create an in vivo model of this immune deficiency, we administered 8-aminoguanosine to rats. This water-soluble nucleoside was rapidly converted by NP t...

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Veröffentlicht in:	Immunology 1986-09, Vol.59 (1), p.63-67
Hauptverfasser:	OSBORNE, W. R. A, BARTON, R. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Deoxyguanine Nucleotides - metabolism Deoxyguanosine - blood Disease Models, Animal Erythrocytes - enzymology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Guanosine - analogs & derivatives Guanosine - toxicity Guanosine Triphosphate - metabolism Immunobiology Lymphoid Tissue - metabolism Male Organs and cells involved in the immune response Pentosyltransferases - deficiency Phosphotransferases (Alcohol Group Acceptor) Phosphotransferases - metabolism Purine-Nucleoside Phosphorylase - antagonists & inhibitors Purine-Nucleoside Phosphorylase - deficiency Rats Rats, Inbred Lew
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