Macromolecular inhibitory factor for lymphoid cells produced by mouse macrophages

Supernatants of high density cultures of mouse peritoneal macrophages were inhibitory to homologous lymphoid cells in vitro by a number of parameters: proliferation and survival of lymphoma cells was impaired, the immune response of spleen cells to sheep red cells and to Concanavalin A (Con A) was d...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunology 1977-09, Vol.33 (3), p.391-398
Hauptverfasser:	Chen, P C, Gaetjens, E, Broome, J D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation Cell Line Cells, Cultured Immunosuppression Lymphocytes - immunology Lymphoma - immunology Macrophages - analysis Macrophages - immunology Mice Mitosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	398
container_issue	3
container_start_page	391
container_title	Immunology
container_volume	33
creator	Chen, P C Gaetjens, E Broome, J D
description	Supernatants of high density cultures of mouse peritoneal macrophages were inhibitory to homologous lymphoid cells in vitro by a number of parameters: proliferation and survival of lymphoma cells was impaired, the immune response of spleen cells to sheep red cells and to Concanavalin A (Con A) was decreased. Inhibition was due to factor(s) with mol. wt of approximately 110,000 as estimated by gel filtration. Activity was stable to heating at 56 degrees, and was resistant to trypsin but not to pronase.
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1445644</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>84068084</sourcerecordid><originalsourceid>FETCH-LOGICAL-p260t-af2d6eb806b062240b9096c667ed47931a0dfe42dfb59f19f43894b2645148833</originalsourceid><addsrcrecordid>eNpVkEtLxDAUhYP4Gkf_gYus3BXSvCbZCDL4ghERdB2SJplG2qYmrdB_b4cZRBeXw-VcvsO5R2BREs4KzPjqGCwQKmWBBWLn4CLnz3kliLEzcCqRYIIuwNuLrlJsY-OqsdEJhq4OJgwxTdDralbo52mmtq9jsLByTZNhn6IdK2ehmWAbx-xgu6P0td66fAlOvG6yuzroEnw83L-vn4rN6-Pz-m5T9JijodAeW-6MQNwgjjFFRiLJK85XztKVJKVG1juKrTdM-lJ6SoSkBnPKSioEIUtwu-f2o2mdrVw3JN2oPoVWp0lFHdR_pwu12sZvVVLKOKUz4OYASPFrdHlQbci7grpzcyklKOICid3h9d-k34j9D8kPOChwcQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84068084</pqid></control><display><type>article</type><title>Macromolecular inhibitory factor for lymphoid cells produced by mouse macrophages</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Chen, P C ; Gaetjens, E ; Broome, J D</creator><creatorcontrib>Chen, P C ; Gaetjens, E ; Broome, J D</creatorcontrib><description>Supernatants of high density cultures of mouse peritoneal macrophages were inhibitory to homologous lymphoid cells in vitro by a number of parameters: proliferation and survival of lymphoma cells was impaired, the immune response of spleen cells to sheep red cells and to Concanavalin A (Con A) was decreased. Inhibition was due to factor(s) with mol. wt of approximately 110,000 as estimated by gel filtration. Activity was stable to heating at 56 degrees, and was resistant to trypsin but not to pronase.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>PMID: 908584</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Antibody Formation ; Cell Line ; Cells, Cultured ; Immunosuppression ; Lymphocytes - immunology ; Lymphoma - immunology ; Macrophages - analysis ; Macrophages - immunology ; Mice ; Mitosis</subject><ispartof>Immunology, 1977-09, Vol.33 (3), p.391-398</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1445644/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1445644/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/908584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, P C</creatorcontrib><creatorcontrib>Gaetjens, E</creatorcontrib><creatorcontrib>Broome, J D</creatorcontrib><title>Macromolecular inhibitory factor for lymphoid cells produced by mouse macrophages</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Supernatants of high density cultures of mouse peritoneal macrophages were inhibitory to homologous lymphoid cells in vitro by a number of parameters: proliferation and survival of lymphoma cells was impaired, the immune response of spleen cells to sheep red cells and to Concanavalin A (Con A) was decreased. Inhibition was due to factor(s) with mol. wt of approximately 110,000 as estimated by gel filtration. Activity was stable to heating at 56 degrees, and was resistant to trypsin but not to pronase.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>Cell Line</subject><subject>Cells, Cultured</subject><subject>Immunosuppression</subject><subject>Lymphocytes - immunology</subject><subject>Lymphoma - immunology</subject><subject>Macrophages - analysis</subject><subject>Macrophages - immunology</subject><subject>Mice</subject><subject>Mitosis</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtLxDAUhYP4Gkf_gYus3BXSvCbZCDL4ghERdB2SJplG2qYmrdB_b4cZRBeXw-VcvsO5R2BREs4KzPjqGCwQKmWBBWLn4CLnz3kliLEzcCqRYIIuwNuLrlJsY-OqsdEJhq4OJgwxTdDralbo52mmtq9jsLByTZNhn6IdK2ehmWAbx-xgu6P0td66fAlOvG6yuzroEnw83L-vn4rN6-Pz-m5T9JijodAeW-6MQNwgjjFFRiLJK85XztKVJKVG1juKrTdM-lJ6SoSkBnPKSioEIUtwu-f2o2mdrVw3JN2oPoVWp0lFHdR_pwu12sZvVVLKOKUz4OYASPFrdHlQbci7grpzcyklKOICid3h9d-k34j9D8kPOChwcQ</recordid><startdate>19770901</startdate><enddate>19770901</enddate><creator>Chen, P C</creator><creator>Gaetjens, E</creator><creator>Broome, J D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19770901</creationdate><title>Macromolecular inhibitory factor for lymphoid cells produced by mouse macrophages</title><author>Chen, P C ; Gaetjens, E ; Broome, J D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p260t-af2d6eb806b062240b9096c667ed47931a0dfe42dfb59f19f43894b2645148833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>Cell Line</topic><topic>Cells, Cultured</topic><topic>Immunosuppression</topic><topic>Lymphocytes - immunology</topic><topic>Lymphoma - immunology</topic><topic>Macrophages - analysis</topic><topic>Macrophages - immunology</topic><topic>Mice</topic><topic>Mitosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, P C</creatorcontrib><creatorcontrib>Gaetjens, E</creatorcontrib><creatorcontrib>Broome, J D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, P C</au><au>Gaetjens, E</au><au>Broome, J D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macromolecular inhibitory factor for lymphoid cells produced by mouse macrophages</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1977-09-01</date><risdate>1977</risdate><volume>33</volume><issue>3</issue><spage>391</spage><epage>398</epage><pages>391-398</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Supernatants of high density cultures of mouse peritoneal macrophages were inhibitory to homologous lymphoid cells in vitro by a number of parameters: proliferation and survival of lymphoma cells was impaired, the immune response of spleen cells to sheep red cells and to Concanavalin A (Con A) was decreased. Inhibition was due to factor(s) with mol. wt of approximately 110,000 as estimated by gel filtration. Activity was stable to heating at 56 degrees, and was resistant to trypsin but not to pronase.</abstract><cop>England</cop><pmid>908584</pmid><tpages>8</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0019-2805
ispartof	Immunology, 1977-09, Vol.33 (3), p.391-398
issn	0019-2805 1365-2567
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1445644
source	MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects	Animals Antibody Formation Cell Line Cells, Cultured Immunosuppression Lymphocytes - immunology Lymphoma - immunology Macrophages - analysis Macrophages - immunology Mice Mitosis
title	Macromolecular inhibitory factor for lymphoid cells produced by mouse macrophages
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T21%3A20%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Macromolecular%20inhibitory%20factor%20for%20lymphoid%20cells%20produced%20by%20mouse%20macrophages&rft.jtitle=Immunology&rft.au=Chen,%20P%20C&rft.date=1977-09-01&rft.volume=33&rft.issue=3&rft.spage=391&rft.epage=398&rft.pages=391-398&rft.issn=0019-2805&rft.eissn=1365-2567&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E84068084%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84068084&rft_id=info:pmid/908584&rfr_iscdi=true