Vitamin A treatment for night blindness in primary biliary cirrhosis
Three patients with late stage primary biliary cirrhosis were found to have appreciable night blindness. Serum vitamin A concentrations were low in all three patients despite regular intramuscular supplementation in two. All patients responded dramatically to high dose oral supplementation, with ful...
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| Veröffentlicht in: | BMJ 1984-04, Vol.288 (6423), p.1030-1031 |
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| container_issue | 6423 |
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| container_title | BMJ |
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| creator | Walt, R P Kemp, C M Lyness, L Bird, A C Sherlock, S |
| description | Three patients with late stage primary biliary cirrhosis were found to have appreciable night blindness. Serum vitamin A concentrations were low in all three patients despite regular intramuscular supplementation in two. All patients responded dramatically to high dose oral supplementation, with full recovery of adaptation to dark and visual fields. Oral rather than intramuscular vitamin A supplementation seems appropriate in the prevention of ocular complications of vitamin A deficiency in biliary cirrhosis. |
| doi_str_mv | 10.1136/bmj.288.6423.1030 |
| format | Article |
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Serum vitamin A concentrations were low in all three patients despite regular intramuscular supplementation in two. All patients responded dramatically to high dose oral supplementation, with full recovery of adaptation to dark and visual fields. Oral rather than intramuscular vitamin A supplementation seems appropriate in the prevention of ocular complications of vitamin A deficiency in biliary cirrhosis.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0267-0623</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.288.6423.1030</identifier><identifier>PMID: 6423181</identifier><identifier>CODEN: BMJOAE</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>Administration, Oral ; Biliary liver cirrhosis ; Biological and medical sciences ; Clinical Research ; Dark adaptation ; Dark Adaptation - drug effects ; Digestive system ; Female ; Humans ; Liver Cirrhosis, Biliary - complications ; Liver diseases ; Medical sciences ; Middle Aged ; Night blindness ; Night Blindness - drug therapy ; Night Blindness - etiology ; Pharmacology. Drug treatments ; Time Factors ; Vitamin A ; Vitamin A - administration & dosage ; Vitamin A - therapeutic use</subject><ispartof>BMJ, 1984-04, Vol.288 (6423), p.1030-1031</ispartof><rights>Copyright 1984 British Medical Journal</rights><rights>1984 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Apr 7, 1984</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b548t-19f94a6003bba6fb288e987d4722de22bf8cd48d44a008e478bd4eb1b841eeb93</citedby><cites>FETCH-LOGICAL-b548t-19f94a6003bba6fb288e987d4722de22bf8cd48d44a008e478bd4eb1b841eeb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29514669$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29514669$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9666473$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6423181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walt, R P</creatorcontrib><creatorcontrib>Kemp, C M</creatorcontrib><creatorcontrib>Lyness, L</creatorcontrib><creatorcontrib>Bird, A C</creatorcontrib><creatorcontrib>Sherlock, S</creatorcontrib><title>Vitamin A treatment for night blindness in primary biliary cirrhosis</title><title>BMJ</title><addtitle>Br Med J (Clin Res Ed)</addtitle><description>Three patients with late stage primary biliary cirrhosis were found to have appreciable night blindness. Serum vitamin A concentrations were low in all three patients despite regular intramuscular supplementation in two. All patients responded dramatically to high dose oral supplementation, with full recovery of adaptation to dark and visual fields. Oral rather than intramuscular vitamin A supplementation seems appropriate in the prevention of ocular complications of vitamin A deficiency in biliary cirrhosis.</description><subject>Administration, Oral</subject><subject>Biliary liver cirrhosis</subject><subject>Biological and medical sciences</subject><subject>Clinical Research</subject><subject>Dark adaptation</subject><subject>Dark Adaptation - drug effects</subject><subject>Digestive system</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Cirrhosis, Biliary - complications</subject><subject>Liver diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Night blindness</subject><subject>Night Blindness - drug therapy</subject><subject>Night Blindness - etiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><subject>Vitamin A</subject><subject>Vitamin A - administration & dosage</subject><subject>Vitamin A - therapeutic use</subject><issn>0007-1447</issn><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUstq3DAUFaElHdJ8QBcFQ0tX8UQvS_KmEKZJWkhbCOksshGSLWc0taVU0pTk7yMzxn1ssrqIc-7lPATAGwSXCBF2qoftEguxZBSTJYIEHoAFokyUlSDkBVhACHmJKOWvwHGM2_zEhIua0UNwOO4ggRbg09omNVhXnBUpGJUG41LR-VA4e7dJhe6ta52JsciU-2AHFR4LbXs7zsaGsPHRxtfgZaf6aI6neQR-XJzfrD6XV98vv6zOrkpdUZFKVHc1VQxCorVinc7iTS14SznGrcFYd6JpqWgpVRAKQ7nQLTUaaUGRMbomR-Dj_u79Tg-mbbLWoHo56ZJeWfkv4uxG3vnfMqeAGRb5wIfpQPC_diYmOdjYmL5XzvhdlALlkHBFMvHdf8St3wWXzUnEOaOkzgozC-1ZTfAxBtPNUhCUY0cydySzTTnmLceO8s7bvz3MG1MjGX8_4So2qu-Cco2NM61mjFFO_pzZxuTDDOO6yl-AjVGVe9zGZB5mXIWfknHCK_ltvZJrfr26vrn4Km8z_2TPHxU_7-IJqkfAyg</recordid><startdate>19840407</startdate><enddate>19840407</enddate><creator>Walt, R P</creator><creator>Kemp, C M</creator><creator>Lyness, L</creator><creator>Bird, A C</creator><creator>Sherlock, S</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19840407</creationdate><title>Vitamin A treatment for night blindness in primary biliary cirrhosis</title><author>Walt, R P ; Kemp, C M ; Lyness, L ; Bird, A C ; Sherlock, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b548t-19f94a6003bba6fb288e987d4722de22bf8cd48d44a008e478bd4eb1b841eeb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Administration, Oral</topic><topic>Biliary liver cirrhosis</topic><topic>Biological and medical sciences</topic><topic>Clinical Research</topic><topic>Dark adaptation</topic><topic>Dark Adaptation - drug effects</topic><topic>Digestive system</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Cirrhosis, Biliary - complications</topic><topic>Liver diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Night blindness</topic><topic>Night Blindness - drug therapy</topic><topic>Night Blindness - etiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><topic>Vitamin A</topic><topic>Vitamin A - administration & dosage</topic><topic>Vitamin A - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walt, R P</creatorcontrib><creatorcontrib>Kemp, C M</creatorcontrib><creatorcontrib>Lyness, L</creatorcontrib><creatorcontrib>Bird, A C</creatorcontrib><creatorcontrib>Sherlock, S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walt, R P</au><au>Kemp, C M</au><au>Lyness, L</au><au>Bird, A C</au><au>Sherlock, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin A treatment for night blindness in primary biliary cirrhosis</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J (Clin Res Ed)</addtitle><date>1984-04-07</date><risdate>1984</risdate><volume>288</volume><issue>6423</issue><spage>1030</spage><epage>1031</epage><pages>1030-1031</pages><issn>0007-1447</issn><issn>0267-0623</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><coden>BMJOAE</coden><abstract>Three patients with late stage primary biliary cirrhosis were found to have appreciable night blindness. Serum vitamin A concentrations were low in all three patients despite regular intramuscular supplementation in two. All patients responded dramatically to high dose oral supplementation, with full recovery of adaptation to dark and visual fields. Oral rather than intramuscular vitamin A supplementation seems appropriate in the prevention of ocular complications of vitamin A deficiency in biliary cirrhosis.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>6423181</pmid><doi>10.1136/bmj.288.6423.1030</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Oral Biliary liver cirrhosis Biological and medical sciences Clinical Research Dark adaptation Dark Adaptation - drug effects Digestive system Female Humans Liver Cirrhosis, Biliary - complications Liver diseases Medical sciences Middle Aged Night blindness Night Blindness - drug therapy Night Blindness - etiology Pharmacology. Drug treatments Time Factors Vitamin A Vitamin A - administration & dosage Vitamin A - therapeutic use |
| title | Vitamin A treatment for night blindness in primary biliary cirrhosis |
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