Flexible induction dose regimen for warfarin and prediction of maintenance dose
Fifty patients with venous thromboembolic disease being treated by heparin infusion received a three day warfarin induction regimen tailored according to the prothrombin time (British comparative ratio) measured on days 2 and 3. A prediction of the final maintenance dose of warfarin was made on the...
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| Veröffentlicht in: | BMJ 1984-04, Vol.288 (6426), p.1268-1270 |
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| creator | Fennerty, A Dolben, J Thomas, P Backhouse, G Bentley, D P Campbell, I A Routledge, P A |
| description | Fifty patients with venous thromboembolic disease being treated by heparin infusion received a three day warfarin induction regimen tailored according to the prothrombin time (British comparative ratio) measured on days 2 and 3. A prediction of the final maintenance dose of warfarin was made on the basis of a prothrombin time measured on day 4. All patients were safely anticoagulated by day 6, and the prediction was accurate to within 1 mg in 46 patients. Predicted and actual maintenance doses were closely related (r = 0.867; n = 50; p less than 0.001). This scheme should prove helpful in the control of anticoagulation, particularly in patients likely to be sensitive to warfarin, and should shorten hospital stay. |
| doi_str_mv | 10.1136/bmj.288.6426.1268 |
| format | Article |
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A prediction of the final maintenance dose of warfarin was made on the basis of a prothrombin time measured on day 4. All patients were safely anticoagulated by day 6, and the prediction was accurate to within 1 mg in 46 patients. Predicted and actual maintenance doses were closely related (r = 0.867; n = 50; p less than 0.001). This scheme should prove helpful in the control of anticoagulation, particularly in patients likely to be sensitive to warfarin, and should shorten hospital stay.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0267-0623</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.288.6426.1268</identifier><identifier>PMID: 6424820</identifier><identifier>CODEN: BMJOAE</identifier><language>eng</language><publisher>London: British Medical Journal Publishing Group</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Clotting ; Dosage ; Drug Administration Schedule ; Female ; Heparin ; Heparin - therapeutic use ; Hospital administration ; Humans ; Male ; Medical sciences ; Medical specialists ; Medical treatment ; Medicine ; Middle Aged ; Pharmacology. Drug treatments ; Physicians ; Prothrombin Time ; Thrombophlebitis - drug therapy ; Thrombophlebitis - physiopathology ; Warfarin - administration & dosage</subject><ispartof>BMJ, 1984-04, Vol.288 (6426), p.1268-1270</ispartof><rights>Copyright 1984 British Medical Journal</rights><rights>1984 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Apr 28, 1984</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b548t-548119c6ac2ddf43d12b9d0d53cf4a53cd7aadd740d0a6c8260f9bbbd254ade73</citedby><cites>FETCH-LOGICAL-b548t-548119c6ac2ddf43d12b9d0d53cf4a53cd7aadd740d0a6c8260f9bbbd254ade73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/29514928$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/29514928$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9642352$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6424820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fennerty, A</creatorcontrib><creatorcontrib>Dolben, J</creatorcontrib><creatorcontrib>Thomas, P</creatorcontrib><creatorcontrib>Backhouse, G</creatorcontrib><creatorcontrib>Bentley, D P</creatorcontrib><creatorcontrib>Campbell, I A</creatorcontrib><creatorcontrib>Routledge, P A</creatorcontrib><title>Flexible induction dose regimen for warfarin and prediction of maintenance dose</title><title>BMJ</title><addtitle>Br Med J (Clin Res Ed)</addtitle><description>Fifty patients with venous thromboembolic disease being treated by heparin infusion received a three day warfarin induction regimen tailored according to the prothrombin time (British comparative ratio) measured on days 2 and 3. A prediction of the final maintenance dose of warfarin was made on the basis of a prothrombin time measured on day 4. All patients were safely anticoagulated by day 6, and the prediction was accurate to within 1 mg in 46 patients. Predicted and actual maintenance doses were closely related (r = 0.867; n = 50; p less than 0.001). This scheme should prove helpful in the control of anticoagulation, particularly in patients likely to be sensitive to warfarin, and should shorten hospital stay.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Clotting</subject><subject>Dosage</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Heparin</subject><subject>Heparin - therapeutic use</subject><subject>Hospital administration</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medical specialists</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicians</subject><subject>Prothrombin Time</subject><subject>Thrombophlebitis - drug therapy</subject><subject>Thrombophlebitis - physiopathology</subject><subject>Warfarin - administration & dosage</subject><issn>0007-1447</issn><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFUcuK1TAYDqKMh3EewIVQUFzZY-5JN4IcHRUGB2Qc3IU0Sccc2-SYtDq-vak91MvGzR_Cd_kvHwAPEdwiRPjzdthvsZRbTjHfIszlHbBBlMuaSULugg2EUNSIUnEfnOW8L19MhGw4PQEnRUMlhhtwed67W9_2rvLBTmb0MVQ2Zlcld-MHF6oupuq7Tp1OPlQ62OqQnPULMXbVoH0YXdDBuF-6B-Bep_vszo7vKfh4_vpq97a-uHzzbvfyom4ZlWNdCkKN4dpgaztKLMJtY6FlxHRUl2qF1tYKCi3U3EjMYde0bWsxo9o6QU7Bi8X3MLWDs8aFMeleHZIfdPqhovbqbyT4z-omflPlIAhKWAyeHg1S_Dq5PKrBZ-P6XgcXp6wkgpgjRgvx8T_EfZxSKMspJASnpMF4ngctLJNizsl16ygIqjkuVeJSJS41x6XmuIrm0Z87rIpjOAV_csR1NrrvUrmyzyutJIkJw79t9nmMaYVxwxBt8NymXnCfR3e74jp9UVwQwdT76526_kA-kSv2Su0K_9nCnyf-_xY_AZ-0xWA</recordid><startdate>19840428</startdate><enddate>19840428</enddate><creator>Fennerty, A</creator><creator>Dolben, J</creator><creator>Thomas, P</creator><creator>Backhouse, G</creator><creator>Bentley, D P</creator><creator>Campbell, I A</creator><creator>Routledge, P A</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19840428</creationdate><title>Flexible induction dose regimen for warfarin and prediction of maintenance dose</title><author>Fennerty, A ; Dolben, J ; Thomas, P ; Backhouse, G ; Bentley, D P ; Campbell, I A ; Routledge, P A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b548t-548119c6ac2ddf43d12b9d0d53cf4a53cd7aadd740d0a6c8260f9bbbd254ade73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Clotting</topic><topic>Dosage</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Heparin</topic><topic>Heparin - therapeutic use</topic><topic>Hospital administration</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medical specialists</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicians</topic><topic>Prothrombin Time</topic><topic>Thrombophlebitis - drug therapy</topic><topic>Thrombophlebitis - physiopathology</topic><topic>Warfarin - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fennerty, A</creatorcontrib><creatorcontrib>Dolben, J</creatorcontrib><creatorcontrib>Thomas, P</creatorcontrib><creatorcontrib>Backhouse, G</creatorcontrib><creatorcontrib>Bentley, D P</creatorcontrib><creatorcontrib>Campbell, I A</creatorcontrib><creatorcontrib>Routledge, P A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fennerty, A</au><au>Dolben, J</au><au>Thomas, P</au><au>Backhouse, G</au><au>Bentley, D P</au><au>Campbell, I A</au><au>Routledge, P A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flexible induction dose regimen for warfarin and prediction of maintenance dose</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J (Clin Res Ed)</addtitle><date>1984-04-28</date><risdate>1984</risdate><volume>288</volume><issue>6426</issue><spage>1268</spage><epage>1270</epage><pages>1268-1270</pages><issn>0007-1447</issn><issn>0267-0623</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><coden>BMJOAE</coden><abstract>Fifty patients with venous thromboembolic disease being treated by heparin infusion received a three day warfarin induction regimen tailored according to the prothrombin time (British comparative ratio) measured on days 2 and 3. A prediction of the final maintenance dose of warfarin was made on the basis of a prothrombin time measured on day 4. All patients were safely anticoagulated by day 6, and the prediction was accurate to within 1 mg in 46 patients. Predicted and actual maintenance doses were closely related (r = 0.867; n = 50; p less than 0.001). This scheme should prove helpful in the control of anticoagulation, particularly in patients likely to be sensitive to warfarin, and should shorten hospital stay.</abstract><cop>London</cop><pub>British Medical Journal Publishing Group</pub><pmid>6424820</pmid><doi>10.1136/bmj.288.6426.1268</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Clotting Dosage Drug Administration Schedule Female Heparin Heparin - therapeutic use Hospital administration Humans Male Medical sciences Medical specialists Medical treatment Medicine Middle Aged Pharmacology. Drug treatments Physicians Prothrombin Time Thrombophlebitis - drug therapy Thrombophlebitis - physiopathology Warfarin - administration & dosage |
| title | Flexible induction dose regimen for warfarin and prediction of maintenance dose |
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