The Molecular Basis for Differential Dioxin Sensitivity in Birds: Role of the Aryl Hydrocarbon Receptor

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatic hydrocarbons (HAHs) are highly toxic to most vertebrate animals, but there are dramatic differences in sensitivity among species and strains. Aquatic birds including the common tern (Sterna hirundo) are highly exposed to HAH...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-04, Vol.103 (16), p.6252-6257
Hauptverfasser:	Karchner, Sibel I., Franks, Diana G., Kennedy, Sean W., Hahn, Mark E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - chemistry Alanine - genetics Amino Acid Sequence Amino Acid Substitution Amino acids Animals Aves Binding sites Biological Sciences Birds Cell culture techniques Charadriiformes - genetics Charadriiformes - physiology Chickens Chickens - genetics Chickens - physiology Complementary DNA COS cells Dioxins Drug Resistance - genetics Gallus gallus Hydrocarbons Ligands Mice Molecular Sequence Data Mutagenesis, Site-Directed Mutation Polychlorinated Dibenzodioxins - metabolism Polychlorinated Dibenzodioxins - toxicity Proteins Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Receptors, Aryl Hydrocarbon - physiology Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Species differences Sterna hirundo Toxicology Transactivation Transcriptional Activation Transfection Valine - chemistry Valine - genetics Vertebrates
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