Voltage-dependent calcium block of normal and tetramethrin-modified single sodium channels

The mechanisms by which external Ca ions block sodium channels were studied by a gigaohm seal patch clamp method using membranes excised from N1E-115 neuroblastoma cells. Tetramethrin was used to prolong the open time of single channels so that the current-voltage relationship could be readily deter...

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Veröffentlicht in:	Biophysical journal 1984, Vol.45 (1), p.337-345
Hauptverfasser:	Yamamoto, D., Yeh, J.Z., Narahashi, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - pharmacology Cell Line Electric Conductivity - drug effects Ion Channels - drug effects Ion Channels - physiology Membrane Potentials - drug effects Mice Neuroblastoma - physiopathology Pyrethrins - pharmacology Sodium - metabolism Thermodynamics
Online-Zugang:	Volltext
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