Granulomatous involvement of the liver in patients with AIDS
During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients were found to have hepatic granulomas....
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| Veröffentlicht in: | Gut 1985-11, Vol.26 (11), p.1220-1225 |
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| container_title | Gut |
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| creator | Orenstein, M S Tavitian, A Yonk, B Dincsoy, H P Zerega, J Iyer, S K Straus, E W |
| description | During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients were found to have hepatic granulomas. Appropriate staining techniques showed acid-fast bacilli in seven of the liver specimens. One specimen contained numerous Cryptococcal organisms. Two biopsies showed granulomas but no organisms. Liver biopsy was found to be a high yield and rapid diagnostic procedure in patients with AIDS. Our results suggest that hepatic mycobacterial infection may be more common in the syndrome than previously recognised and that liver biopsy specimens should be examined routinely for the presence of acid-fast bacilli. |
| doi_str_mv | 10.1136/gut.26.11.1220 |
| format | Article |
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Each of the 10 patients were found to have hepatic granulomas. Appropriate staining techniques showed acid-fast bacilli in seven of the liver specimens. One specimen contained numerous Cryptococcal organisms. Two biopsies showed granulomas but no organisms. Liver biopsy was found to be a high yield and rapid diagnostic procedure in patients with AIDS. Our results suggest that hepatic mycobacterial infection may be more common in the syndrome than previously recognised and that liver biopsy specimens should be examined routinely for the presence of acid-fast bacilli.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.26.11.1220</identifier><identifier>PMID: 4065697</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - pathology ; Adult ; AIDS/HIV ; Biological and medical sciences ; Female ; Granuloma - complications ; Granuloma - pathology ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Liver - pathology ; Liver Diseases - complications ; Liver Diseases - pathology ; Male ; Medical sciences ; Mycobacterium Infections, Nontuberculous - complications ; Mycobacterium Infections, Nontuberculous - pathology ; Tuberculosis, Hepatic - complications ; Tuberculosis, Hepatic - pathology</subject><ispartof>Gut, 1985-11, Vol.26 (11), p.1220-1225</ispartof><rights>1986 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Nov 1985</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b514t-ffba8d335aebb34bfd21c73b31565309f92557b370c5807af6a0d1957bbebed83</citedby><cites>FETCH-LOGICAL-b514t-ffba8d335aebb34bfd21c73b31565309f92557b370c5807af6a0d1957bbebed83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1432921/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1432921/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8570396$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4065697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orenstein, M S</creatorcontrib><creatorcontrib>Tavitian, A</creatorcontrib><creatorcontrib>Yonk, B</creatorcontrib><creatorcontrib>Dincsoy, H P</creatorcontrib><creatorcontrib>Zerega, J</creatorcontrib><creatorcontrib>Iyer, S K</creatorcontrib><creatorcontrib>Straus, E W</creatorcontrib><title>Granulomatous involvement of the liver in patients with AIDS</title><title>Gut</title><addtitle>Gut</addtitle><description>During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients were found to have hepatic granulomas. Appropriate staining techniques showed acid-fast bacilli in seven of the liver specimens. One specimen contained numerous Cryptococcal organisms. Two biopsies showed granulomas but no organisms. Liver biopsy was found to be a high yield and rapid diagnostic procedure in patients with AIDS. Our results suggest that hepatic mycobacterial infection may be more common in the syndrome than previously recognised and that liver biopsy specimens should be examined routinely for the presence of acid-fast bacilli.</description><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - pathology</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Granuloma - complications</subject><subject>Granuloma - pathology</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Liver - pathology</subject><subject>Liver Diseases - complications</subject><subject>Liver Diseases - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium Infections, Nontuberculous - complications</subject><subject>Mycobacterium Infections, Nontuberculous - pathology</subject><subject>Tuberculosis, Hepatic - complications</subject><subject>Tuberculosis, Hepatic - pathology</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkd2LEzEUxYMoa3f11TdhQBF8mJqPyRcswlK1u1AU_NjXkMwk29SZSU0yXf3vTWkp6otPudzzy-UcDgDPEJwjRNibuynPMSvzHGEMH4AZapioCRbiIZhBiHhNeSMfg_OUNhBCISQ6A2cNZJRJPgOXy6jHqQ-DzmFKlR93od_ZwY65Cq7Ka1v1fmdjEaqtzr7sU3Xv87q6unn35Ql45HSf7NPjewG-fXj_dXFdrz4tbxZXq9pQ1OTaOaNFRwjV1hjSGNdh1HJiCKKMEiidxJRyQzhsqYBcO6Zhh2RZGWtsJ8gFeHu4u53MYLu2uIi6V9voBx1_qaC9-lsZ_VrdhZ1CDcESo3Lg1fFADD8mm7IafGpt3-vRltiKs4ZzKPbgi3_ATZjiWMIpVAjYCE721PxAtTGkFK07WUFQ7VtRpRWFWZnVvpXy4fmfAU74sYaivzzqOrW6d6WT1qcTJiiHRLKC1QfMp2x_nmQdvyvGCafq4-1CoeVKwmt8qz4X_vWBN8PmfxZ_A6HksWU</recordid><startdate>19851101</startdate><enddate>19851101</enddate><creator>Orenstein, M S</creator><creator>Tavitian, A</creator><creator>Yonk, B</creator><creator>Dincsoy, H P</creator><creator>Zerega, J</creator><creator>Iyer, S K</creator><creator>Straus, E W</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19851101</creationdate><title>Granulomatous involvement of the liver in patients with AIDS</title><author>Orenstein, M S ; Tavitian, A ; Yonk, B ; Dincsoy, H P ; Zerega, J ; Iyer, S K ; Straus, E W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b514t-ffba8d335aebb34bfd21c73b31565309f92557b370c5807af6a0d1957bbebed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acquired Immunodeficiency Syndrome - pathology</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Granuloma - complications</topic><topic>Granuloma - pathology</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Liver - pathology</topic><topic>Liver Diseases - complications</topic><topic>Liver Diseases - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycobacterium Infections, Nontuberculous - complications</topic><topic>Mycobacterium Infections, Nontuberculous - pathology</topic><topic>Tuberculosis, Hepatic - complications</topic><topic>Tuberculosis, Hepatic - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orenstein, M S</creatorcontrib><creatorcontrib>Tavitian, A</creatorcontrib><creatorcontrib>Yonk, B</creatorcontrib><creatorcontrib>Dincsoy, H P</creatorcontrib><creatorcontrib>Zerega, J</creatorcontrib><creatorcontrib>Iyer, S K</creatorcontrib><creatorcontrib>Straus, E W</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orenstein, M S</au><au>Tavitian, A</au><au>Yonk, B</au><au>Dincsoy, H P</au><au>Zerega, J</au><au>Iyer, S K</au><au>Straus, E W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Granulomatous involvement of the liver in patients with AIDS</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1985-11-01</date><risdate>1985</risdate><volume>26</volume><issue>11</issue><spage>1220</spage><epage>1225</epage><pages>1220-1225</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>During a one month period liver biopsy was carried out on eight patients with established acquired immune deficiency syndrome (AIDS) and two suspected of having AIDS to evaluate raised liver enzymes or unexplained fever and weight loss. Each of the 10 patients were found to have hepatic granulomas. Appropriate staining techniques showed acid-fast bacilli in seven of the liver specimens. One specimen contained numerous Cryptococcal organisms. Two biopsies showed granulomas but no organisms. Liver biopsy was found to be a high yield and rapid diagnostic procedure in patients with AIDS. Our results suggest that hepatic mycobacterial infection may be more common in the syndrome than previously recognised and that liver biopsy specimens should be examined routinely for the presence of acid-fast bacilli.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>4065697</pmid><doi>10.1136/gut.26.11.1220</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gut, 1985-11, Vol.26 (11), p.1220-1225 |
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| subjects | Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - pathology Adult AIDS/HIV Biological and medical sciences Female Granuloma - complications Granuloma - pathology Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Liver - pathology Liver Diseases - complications Liver Diseases - pathology Male Medical sciences Mycobacterium Infections, Nontuberculous - complications Mycobacterium Infections, Nontuberculous - pathology Tuberculosis, Hepatic - complications Tuberculosis, Hepatic - pathology |
| title | Granulomatous involvement of the liver in patients with AIDS |
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