Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats
The effects of beta-urogastrone/human epidermal growth factor (URO-EGF) on intestinal epithelial cell proliferation were studied in rats in which intestinal cell proliferation had been reduced to a steady state basal level, by maintaining the rats on total parenteral nutrition. The accumulation of a...
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| Veröffentlicht in: | Gut 1987-05, Vol.28 (5), p.573-582 |
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| creator | Goodlad, R A Wilson, T J Lenton, W Gregory, H McCullagh, K G Wright, N A |
| description | The effects of beta-urogastrone/human epidermal growth factor (URO-EGF) on intestinal epithelial cell proliferation were studied in rats in which intestinal cell proliferation had been reduced to a steady state basal level, by maintaining the rats on total parenteral nutrition. The accumulation of arrested metaphases over a two hour time period was determined in a dose response study. Increasing doses of URO-EGF progressively raised the two hour collection of metaphases and intestinal weights. Intravenous infusion of URO-EGF was also effective in restoring cell proliferation when it was infused after the intestine had become hypoproliferative. beta-urogastrone/human epidermal growth factor administered through an intragastric cannulae thrice daily had no significant effect on intestinal weight or crypt cell production rate or metaphase collection. It is proposed that one of the in vivo actions of urogastrone-epidermal growth factor is the maintenance of gastrointestinal growth and that this occurs through a systemic rather than a luminal mechanism. |
| doi_str_mv | 10.1136/gut.28.5.573 |
| format | Article |
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The accumulation of arrested metaphases over a two hour time period was determined in a dose response study. Increasing doses of URO-EGF progressively raised the two hour collection of metaphases and intestinal weights. Intravenous infusion of URO-EGF was also effective in restoring cell proliferation when it was infused after the intestine had become hypoproliferative. beta-urogastrone/human epidermal growth factor administered through an intragastric cannulae thrice daily had no significant effect on intestinal weight or crypt cell production rate or metaphase collection. It is proposed that one of the in vivo actions of urogastrone-epidermal growth factor is the maintenance of gastrointestinal growth and that this occurs through a systemic rather than a luminal mechanism.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.28.5.573</identifier><identifier>PMID: 3110021</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Cell Division - drug effects ; Digestive System - cytology ; Digestive System - drug effects ; Digestive System Physiological Phenomena ; Dose-Response Relationship, Drug ; Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition ; Epidermal Growth Factor - administration & dosage ; Epidermal Growth Factor - pharmacology ; Epithelial Cells ; Infusions, Intravenous ; Intensive care medicine ; Intubation, Gastrointestinal ; Male ; Medical sciences ; Parenteral Nutrition ; Rats ; Rats, Inbred Strains</subject><ispartof>Gut, 1987-05, Vol.28 (5), p.573-582</ispartof><rights>1987 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD May 1987</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b535t-84da96e0c526ad24c0ac897768331044064f9356b2560fbbab60c05d830d5f883</citedby><cites>FETCH-LOGICAL-b535t-84da96e0c526ad24c0ac897768331044064f9356b2560fbbab60c05d830d5f883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1432884/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1432884/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8313871$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3110021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goodlad, R A</creatorcontrib><creatorcontrib>Wilson, T J</creatorcontrib><creatorcontrib>Lenton, W</creatorcontrib><creatorcontrib>Gregory, H</creatorcontrib><creatorcontrib>McCullagh, K G</creatorcontrib><creatorcontrib>Wright, N A</creatorcontrib><title>Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats</title><title>Gut</title><addtitle>Gut</addtitle><description>The effects of beta-urogastrone/human epidermal growth factor (URO-EGF) on intestinal epithelial cell proliferation were studied in rats in which intestinal cell proliferation had been reduced to a steady state basal level, by maintaining the rats on total parenteral nutrition. The accumulation of arrested metaphases over a two hour time period was determined in a dose response study. Increasing doses of URO-EGF progressively raised the two hour collection of metaphases and intestinal weights. Intravenous infusion of URO-EGF was also effective in restoring cell proliferation when it was infused after the intestine had become hypoproliferative. beta-urogastrone/human epidermal growth factor administered through an intragastric cannulae thrice daily had no significant effect on intestinal weight or crypt cell production rate or metaphase collection. It is proposed that one of the in vivo actions of urogastrone-epidermal growth factor is the maintenance of gastrointestinal growth and that this occurs through a systemic rather than a luminal mechanism.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Digestive System - cytology</subject><subject>Digestive System - drug effects</subject><subject>Digestive System Physiological Phenomena</subject><subject>Dose-Response Relationship, Drug</subject><subject>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</subject><subject>Epidermal Growth Factor - administration & dosage</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Epithelial Cells</subject><subject>Infusions, Intravenous</subject><subject>Intensive care medicine</subject><subject>Intubation, Gastrointestinal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parenteral Nutrition</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1vEzEQxS0EKmnhxhXJEqhc2GCvP_dSCaKmVKr4EIWr5fV6E4eNHWxvRf97vCSKgAMne-b9NHozD4BnGM0xJvzNaszzWs7ZnAnyAMww5bIitZQPwQwhLComaPMYnKa0QQhJ2eATcEIwRqjGM2CvfY76zvowJtiOGfqQoZt6K51ydAaOMfz-Bm-ry6sldAmWYrcuUg4wr-2E25SdtzD0cKejLXXUw3APe9vBqHN6Ah71ekj26eE9A1-Xl7eL99XNx6vrxdubqmWE5UrSTjfcIsNqrruaGqSNbITgkhCMKEWc9g1hvK0ZR33b6pYjg1gnCepYLyU5Axf7ubux3drO2GmRQe2i2-p4r4J26m_Fu7VahTuF6XQxWgacHwbE8GMsW6mtS8YOg_a2XEgJwSTChBXwxT_gJozRl-UUFgIVp7Se_LzeUyaGlKLtj1YwUlN4qoSnaqmYKuEV_Pmf9o_wIa2ivzzoOhk99FF749IRkwQTKSas2mMuZfvzKOv4XXFBBFMfvi3U50_vyPJWflFN4V_t-Xa7-b_BX3KwvvM</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Goodlad, R A</creator><creator>Wilson, T J</creator><creator>Lenton, W</creator><creator>Gregory, H</creator><creator>McCullagh, K G</creator><creator>Wright, N A</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19870501</creationdate><title>Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats</title><author>Goodlad, R A ; Wilson, T J ; Lenton, W ; Gregory, H ; McCullagh, K G ; Wright, N A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b535t-84da96e0c526ad24c0ac897768331044064f9356b2560fbbab60c05d830d5f883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Digestive System - cytology</topic><topic>Digestive System - drug effects</topic><topic>Digestive System Physiological Phenomena</topic><topic>Dose-Response Relationship, Drug</topic><topic>Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition</topic><topic>Epidermal Growth Factor - administration & dosage</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Epithelial Cells</topic><topic>Infusions, Intravenous</topic><topic>Intensive care medicine</topic><topic>Intubation, Gastrointestinal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parenteral Nutrition</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goodlad, R A</creatorcontrib><creatorcontrib>Wilson, T J</creatorcontrib><creatorcontrib>Lenton, W</creatorcontrib><creatorcontrib>Gregory, H</creatorcontrib><creatorcontrib>McCullagh, K G</creatorcontrib><creatorcontrib>Wright, N A</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goodlad, R A</au><au>Wilson, T J</au><au>Lenton, W</au><au>Gregory, H</au><au>McCullagh, K G</au><au>Wright, N A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>28</volume><issue>5</issue><spage>573</spage><epage>582</epage><pages>573-582</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>The effects of beta-urogastrone/human epidermal growth factor (URO-EGF) on intestinal epithelial cell proliferation were studied in rats in which intestinal cell proliferation had been reduced to a steady state basal level, by maintaining the rats on total parenteral nutrition. The accumulation of arrested metaphases over a two hour time period was determined in a dose response study. Increasing doses of URO-EGF progressively raised the two hour collection of metaphases and intestinal weights. Intravenous infusion of URO-EGF was also effective in restoring cell proliferation when it was infused after the intestine had become hypoproliferative. beta-urogastrone/human epidermal growth factor administered through an intragastric cannulae thrice daily had no significant effect on intestinal weight or crypt cell production rate or metaphase collection. It is proposed that one of the in vivo actions of urogastrone-epidermal growth factor is the maintenance of gastrointestinal growth and that this occurs through a systemic rather than a luminal mechanism.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>3110021</pmid><doi>10.1136/gut.28.5.573</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gut, 1987-05, Vol.28 (5), p.573-582 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cell Division - drug effects Digestive System - cytology Digestive System - drug effects Digestive System Physiological Phenomena Dose-Response Relationship, Drug Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Epidermal Growth Factor - administration & dosage Epidermal Growth Factor - pharmacology Epithelial Cells Infusions, Intravenous Intensive care medicine Intubation, Gastrointestinal Male Medical sciences Parenteral Nutrition Rats Rats, Inbred Strains |
| title | Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats |
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