Phenytoin absorption in patients with ileojejunal bypass
1 The absorption and elimination of phenytoin was studied after a 200 mg oral dose was administered to seven patients with ileojejunal bypass and nine control patients. 2 Analysis of the area under the plasma concentration time curve showed the absorption of phenytoin was decreased in the subjects w...
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| Veröffentlicht in: | British journal of clinical pharmacology 1979-05, Vol.7 (5), p.515-518 |
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| container_title | British journal of clinical pharmacology |
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| creator | Kennedy, MC Wade, DN |
| description | 1 The absorption and elimination of phenytoin was studied after a 200 mg oral dose was administered to seven patients with ileojejunal bypass and nine control patients. 2 Analysis of the area under the plasma concentration time curve showed the absorption of phenytoin was decreased in the subjects with ileojejunal bypass (P less than 0.005). 3 The half life of elimination of the drug was shorter in the bypass group (15.1 h) than in the controls (17.8 h, P less than 0.05). 4 Subjects with an ileojejunal bypass receiving phenytoin are likely to require increased oral dosages to achieve an optimal plasma concentration. There is probably malabsorption of other poorly soluble drugs and parenteral therapy may be necessary to ensure adequate bioavailability. |
| doi_str_mv | 10.1111/j.1365-2125.1979.tb00996.x |
| format | Article |
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There is probably malabsorption of other poorly soluble drugs and parenteral therapy may be necessary to ensure adequate bioavailability.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1979.tb00996.x</identifier><identifier>PMID: 475946</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Female ; Humans ; Ileum - metabolism ; Ileum - surgery ; Intestinal Absorption ; Jejunum - metabolism ; Jejunum - surgery ; Kinetics ; Male ; Middle Aged ; Obesity - therapy ; Phenytoin - blood ; Phenytoin - metabolism ; Time Factors</subject><ispartof>British journal of clinical pharmacology, 1979-05, Vol.7 (5), p.515-518</ispartof><rights>1979 The British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4446-258c47253d083ec72aa1c126dd8b933be168b948072a81e81df6ccaf6afc1e9e3</citedby><cites>FETCH-LOGICAL-c4446-258c47253d083ec72aa1c126dd8b933be168b948072a81e81df6ccaf6afc1e9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/475946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kennedy, MC</creatorcontrib><creatorcontrib>Wade, DN</creatorcontrib><title>Phenytoin absorption in patients with ileojejunal bypass</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>1 The absorption and elimination of phenytoin was studied after a 200 mg oral dose was administered to seven patients with ileojejunal bypass and nine control patients. 2 Analysis of the area under the plasma concentration time curve showed the absorption of phenytoin was decreased in the subjects with ileojejunal bypass (P less than 0.005). 3 The half life of elimination of the drug was shorter in the bypass group (15.1 h) than in the controls (17.8 h, P less than 0.05). 4 Subjects with an ileojejunal bypass receiving phenytoin are likely to require increased oral dosages to achieve an optimal plasma concentration. There is probably malabsorption of other poorly soluble drugs and parenteral therapy may be necessary to ensure adequate bioavailability.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Ileum - metabolism</subject><subject>Ileum - surgery</subject><subject>Intestinal Absorption</subject><subject>Jejunum - metabolism</subject><subject>Jejunum - surgery</subject><subject>Kinetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - therapy</subject><subject>Phenytoin - blood</subject><subject>Phenytoin - metabolism</subject><subject>Time Factors</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtOwzAQRS3EqxT-gEXEPsHv2CyQoOIlVaILWFuO41BHaRLFgTZ_j6NWBZbMZmZ0de-MDgBXCCYo1HWZIMJZjBFmCZKpTPoMQil5sjkAk710CCaQQB4zzNApOPO-hBARxNkJOKYpk5RPgFgsbT30jasjnfmma3vX1FHYWt07W_c-Wrt-GbnKNqUtP2tdRdnQau_PwVGhK28vdn0K3h8f3mbP8fz16WV2N48NpZTHmAlDU8xIDgWxJsVaI4Mwz3ORSUIyi3gYqIBBEcgKlBfcGF1wXRhkpSVTcLvNbT-zlc1N-KnTlWo7t9LdoBrt1F-ldkv10XwpRLFkqQgBN9sA0zXed7bYexFUI01VqhGZGpGpkaba0VSbYL78fX1v3eL7eW4dAA3_CFb3s0UYyDfb4Icf</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>Kennedy, MC</creator><creator>Wade, DN</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>197905</creationdate><title>Phenytoin absorption in patients with ileojejunal bypass</title><author>Kennedy, MC ; Wade, DN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4446-258c47253d083ec72aa1c126dd8b933be168b948072a81e81df6ccaf6afc1e9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Ileum - metabolism</topic><topic>Ileum - surgery</topic><topic>Intestinal Absorption</topic><topic>Jejunum - metabolism</topic><topic>Jejunum - surgery</topic><topic>Kinetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - therapy</topic><topic>Phenytoin - blood</topic><topic>Phenytoin - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kennedy, MC</creatorcontrib><creatorcontrib>Wade, DN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kennedy, MC</au><au>Wade, DN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenytoin absorption in patients with ileojejunal bypass</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1979-05</date><risdate>1979</risdate><volume>7</volume><issue>5</issue><spage>515</spage><epage>518</epage><pages>515-518</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><abstract>1 The absorption and elimination of phenytoin was studied after a 200 mg oral dose was administered to seven patients with ileojejunal bypass and nine control patients. 2 Analysis of the area under the plasma concentration time curve showed the absorption of phenytoin was decreased in the subjects with ileojejunal bypass (P less than 0.005). 3 The half life of elimination of the drug was shorter in the bypass group (15.1 h) than in the controls (17.8 h, P less than 0.05). 4 Subjects with an ileojejunal bypass receiving phenytoin are likely to require increased oral dosages to achieve an optimal plasma concentration. There is probably malabsorption of other poorly soluble drugs and parenteral therapy may be necessary to ensure adequate bioavailability.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>475946</pmid><doi>10.1111/j.1365-2125.1979.tb00996.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1979-05, Vol.7 (5), p.515-518 |
| issn | 0306-5251 1365-2125 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Female Humans Ileum - metabolism Ileum - surgery Intestinal Absorption Jejunum - metabolism Jejunum - surgery Kinetics Male Middle Aged Obesity - therapy Phenytoin - blood Phenytoin - metabolism Time Factors |
| title | Phenytoin absorption in patients with ileojejunal bypass |
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