The disposition of debrisoquine in hypertensive patients

1 The urinary recovery and plasma concentration of debrisoquine (D) and its metabolite 4-hydroxydebrisoquine (HD) has been studied following single and multiple oral administration of debrisoquine hemisulphate to 15 hypertensive in-patients and four normal volunteers. 2 Incremental doses and prolong...

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Veröffentlicht in:	British journal of clinical pharmacology 1978-01, Vol.5 (1), p.27-34
Hauptverfasser:	Silas, JH, Lennard, MS, Tucker, GT, Smith, AJ, Malcolm, SL, Marten, TR
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Pressure - drug effects Debrisoquin - administration & dosage Debrisoquin - metabolism Debrisoquin - therapeutic use Drug Administration Schedule Food Humans Hypertension - drug therapy Hypertension - metabolism Isoquinolines - metabolism Kidney - metabolism Kinetics Male
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