Magnitude and mechanisms of the antihypertensive action of labetalol, including ambulatory assessment
The blood pressure (BP) effect and modes of action of a twice daily regimen of labetalol (mean 450 mg/day) were assessed in ten mild to moderate hypertensives using continuous ambulatory BP monitoring. The reflex control of BP during physiological interventions was examined just prior to the next do...
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| Veröffentlicht in: | British journal of clinical pharmacology 1983-07, Vol.16 (1), p.9-16 |
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| creator | Bellamy, GR Hunyor, SN Roffe, D Massang, J |
| description | The blood pressure (BP) effect and modes of action of a twice daily regimen of labetalol (mean 450 mg/day) were assessed in ten mild to moderate hypertensives using continuous ambulatory BP monitoring. The reflex control of BP during physiological interventions was examined just prior to the next dose of medication to estimate the residual alpha‐ and beta‐adrenoceptor blockade. Global 24 h BP was reduced by 15/9 mm Hg, and home pressures by 13/11 mm Hg. The predominant antihypertensive effect was noted during the waking hours. During dynamic exercise significant inhibition of the heart rate and blood pressure rise occurred. Coupled with a reduction of the post‐release BP ‘overshoot’ in Valsalva's manoeuvre, the response resembles that seen with beta‐adrenoceptor blockade. A small alpha‐adrenoceptor blocking action was evident in one patient's response to the Valsalva manoeuvre. |
| doi_str_mv | 10.1111/j.1365-2125.1983.tb02137.x |
| format | Article |
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The reflex control of BP during physiological interventions was examined just prior to the next dose of medication to estimate the residual alpha‐ and beta‐adrenoceptor blockade. Global 24 h BP was reduced by 15/9 mm Hg, and home pressures by 13/11 mm Hg. The predominant antihypertensive effect was noted during the waking hours. During dynamic exercise significant inhibition of the heart rate and blood pressure rise occurred. Coupled with a reduction of the post‐release BP ‘overshoot’ in Valsalva's manoeuvre, the response resembles that seen with beta‐adrenoceptor blockade. A small alpha‐adrenoceptor blocking action was evident in one patient's response to the Valsalva manoeuvre.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1983.tb02137.x</identifier><identifier>PMID: 6882628</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Antihypertensive Agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Ethanolamines - therapeutic use ; Humans ; Hypertension - drug therapy ; Isometric Contraction ; Labetalol - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Valsalva Maneuver</subject><ispartof>British journal of clinical pharmacology, 1983-07, Vol.16 (1), p.9-16</ispartof><rights>1983 The British Pharmacological Society</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5067-9b0f7b46f45456737c7779a1b96db396ccc0b1c8684d5d589a77fc68e7e3beed3</citedby><cites>FETCH-LOGICAL-c5067-9b0f7b46f45456737c7779a1b96db396ccc0b1c8684d5d589a77fc68e7e3beed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9393812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6882628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bellamy, GR</creatorcontrib><creatorcontrib>Hunyor, SN</creatorcontrib><creatorcontrib>Roffe, D</creatorcontrib><creatorcontrib>Massang, J</creatorcontrib><title>Magnitude and mechanisms of the antihypertensive action of labetalol, including ambulatory assessment</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>The blood pressure (BP) effect and modes of action of a twice daily regimen of labetalol (mean 450 mg/day) were assessed in ten mild to moderate hypertensives using continuous ambulatory BP monitoring. The reflex control of BP during physiological interventions was examined just prior to the next dose of medication to estimate the residual alpha‐ and beta‐adrenoceptor blockade. Global 24 h BP was reduced by 15/9 mm Hg, and home pressures by 13/11 mm Hg. The predominant antihypertensive effect was noted during the waking hours. During dynamic exercise significant inhibition of the heart rate and blood pressure rise occurred. Coupled with a reduction of the post‐release BP ‘overshoot’ in Valsalva's manoeuvre, the response resembles that seen with beta‐adrenoceptor blockade. A small alpha‐adrenoceptor blocking action was evident in one patient's response to the Valsalva manoeuvre.</description><subject>Adult</subject><subject>Antihypertensive Agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Ethanolamines - therapeutic use</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Isometric Contraction</subject><subject>Labetalol - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Valsalva Maneuver</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV2r1DAQhoMox_XoTxCKiFe2Jk3z5YWii19wRC_0OiTpdDdLmq5Nejz7723ZsuiluZkw7zvvDDwIPSO4IvN7dagI5aysSc0qoiStssU1oaK6u4c2F-k-2mCKeclqRh6iRykdMCaUcHaFrriUNa_lBsFXs4s-Ty0UJrZFD25vok99KoauyPulm_3-dIQxQ0z-dm647Ie4yMFYyCYM4WXhowtT6-OuML2dgsnDeCpMSpBSDzE_Rg86ExI8Wes1-vnxw4_t5_Lm26cv23c3pWOYi1JZ3Anb8K5hDeOCCieEUIZYxVtLFXfOYUuc5LJpWcukMkJ0jksQQC1AS6_Rm3PucbI9tG5ePZqgj6PvzXjSg_H6XyX6vd4Nt5o0tVCMzAEv1oBx-DVByrr3yUEIJsIwJS0xJ43Aaja-PhvdOKQ0QndZQrBeIOmDXkjohYReIOkVkr6bh5_-feZldKUy689X3SRnQjea6Hy62BRVVJJ6tr092377AKf_OEC_335ffvQP32ayVg</recordid><startdate>198307</startdate><enddate>198307</enddate><creator>Bellamy, GR</creator><creator>Hunyor, SN</creator><creator>Roffe, D</creator><creator>Massang, J</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198307</creationdate><title>Magnitude and mechanisms of the antihypertensive action of labetalol, including ambulatory assessment</title><author>Bellamy, GR ; Hunyor, SN ; Roffe, D ; Massang, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5067-9b0f7b46f45456737c7779a1b96db396ccc0b1c8684d5d589a77fc68e7e3beed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Antihypertensive Agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular system</topic><topic>Ethanolamines - therapeutic use</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Isometric Contraction</topic><topic>Labetalol - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Valsalva Maneuver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellamy, GR</creatorcontrib><creatorcontrib>Hunyor, SN</creatorcontrib><creatorcontrib>Roffe, D</creatorcontrib><creatorcontrib>Massang, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellamy, GR</au><au>Hunyor, SN</au><au>Roffe, D</au><au>Massang, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnitude and mechanisms of the antihypertensive action of labetalol, including ambulatory assessment</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1983-07</date><risdate>1983</risdate><volume>16</volume><issue>1</issue><spage>9</spage><epage>16</epage><pages>9-16</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>The blood pressure (BP) effect and modes of action of a twice daily regimen of labetalol (mean 450 mg/day) were assessed in ten mild to moderate hypertensives using continuous ambulatory BP monitoring. The reflex control of BP during physiological interventions was examined just prior to the next dose of medication to estimate the residual alpha‐ and beta‐adrenoceptor blockade. Global 24 h BP was reduced by 15/9 mm Hg, and home pressures by 13/11 mm Hg. The predominant antihypertensive effect was noted during the waking hours. During dynamic exercise significant inhibition of the heart rate and blood pressure rise occurred. Coupled with a reduction of the post‐release BP ‘overshoot’ in Valsalva's manoeuvre, the response resembles that seen with beta‐adrenoceptor blockade. A small alpha‐adrenoceptor blocking action was evident in one patient's response to the Valsalva manoeuvre.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6882628</pmid><doi>10.1111/j.1365-2125.1983.tb02137.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1983-07, Vol.16 (1), p.9-16 |
| issn | 0306-5251 1365-2125 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Antihypertensive Agents Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Ethanolamines - therapeutic use Humans Hypertension - drug therapy Isometric Contraction Labetalol - therapeutic use Male Medical sciences Middle Aged Pharmacology. Drug treatments Valsalva Maneuver |
| title | Magnitude and mechanisms of the antihypertensive action of labetalol, including ambulatory assessment |
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