Pharmacokinetics of valproic acid in young and elderly subjects
The disposition of valproic acid was studied following single dose intravenous administration in seven young male volunteers aged 20‐35 years and six elderly male in‐patients aged 75‐87 years. Following administration of 400 mg sodium valproate, blood samples were collected for 48 h and valproic aci...
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| Veröffentlicht in: | British journal of clinical pharmacology 1983-07, Vol.16 (1), p.104-105 |
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| creator | Bryson, SM Verma, N Scott, PJ Rubin, PC |
| description | The disposition of valproic acid was studied following single dose intravenous administration in seven young male volunteers aged 20‐35 years and six elderly male in‐patients aged 75‐87 years. Following administration of 400 mg sodium valproate, blood samples were collected for 48 h and valproic acid concentrations analysed by enzymatic immunoassay. The median elimination half‐life was 7.2 h in the young subjects but 14.9 h in the elderly patients (P less than 0.01). However, clearance did not differ significantly between groups, the values for young and old being 0.69 and 0.58 1/h respectively. The prolonged half‐life resulted from a greater volume of distribution in the elderly. The median values (1/kg) for young and old were 0.13 and 0.19 respectively (P less than 0.01). These pharmacokinetic changes are unlikely to be of clinical importance. |
| doi_str_mv | 10.1111/j.1365-2125.1983.tb02151.x |
| format | Article |
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Following administration of 400 mg sodium valproate, blood samples were collected for 48 h and valproic acid concentrations analysed by enzymatic immunoassay. The median elimination half‐life was 7.2 h in the young subjects but 14.9 h in the elderly patients (P less than 0.01). However, clearance did not differ significantly between groups, the values for young and old being 0.69 and 0.58 1/h respectively. The prolonged half‐life resulted from a greater volume of distribution in the elderly. The median values (1/kg) for young and old were 0.13 and 0.19 respectively (P less than 0.01). These pharmacokinetic changes are unlikely to be of clinical importance.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1983.tb02151.x</identifier><identifier>PMID: 6411107</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Humans ; Injections, Intravenous ; Kinetics ; Medical sciences ; Models, Biological ; Neuropharmacology ; Pharmacology. Drug treatments ; Valproic Acid - metabolism</subject><ispartof>British journal of clinical pharmacology, 1983-07, Vol.16 (1), p.104-105</ispartof><rights>1983 The British Pharmacological Society</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5061-38fc51309e86899e7d8d4ef04845fc0291356e1c34c55b71771e64a9db405e73</citedby><cites>FETCH-LOGICAL-c5061-38fc51309e86899e7d8d4ef04845fc0291356e1c34c55b71771e64a9db405e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9400626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6411107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bryson, SM</creatorcontrib><creatorcontrib>Verma, N</creatorcontrib><creatorcontrib>Scott, PJ</creatorcontrib><creatorcontrib>Rubin, PC</creatorcontrib><title>Pharmacokinetics of valproic acid in young and elderly subjects</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>The disposition of valproic acid was studied following single dose intravenous administration in seven young male volunteers aged 20‐35 years and six elderly male in‐patients aged 75‐87 years. Following administration of 400 mg sodium valproate, blood samples were collected for 48 h and valproic acid concentrations analysed by enzymatic immunoassay. The median elimination half‐life was 7.2 h in the young subjects but 14.9 h in the elderly patients (P less than 0.01). However, clearance did not differ significantly between groups, the values for young and old being 0.69 and 0.58 1/h respectively. The prolonged half‐life resulted from a greater volume of distribution in the elderly. The median values (1/kg) for young and old were 0.13 and 0.19 respectively (P less than 0.01). These pharmacokinetic changes are unlikely to be of clinical importance.</description><subject>Adult</subject><subject>Aged</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Valproic Acid - metabolism</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkEtP3DAUha2qiA6Pn1ApQhW7BN_4kYQFiI5oi4QEC_aW49yAp554aifA_PsmmmhUlr0bX-mce3z0EXIGNINxLlYZMCnSHHKRQVWyrK9pDgKy909ksZc-kwVlVKYiF_CFHMW4ohQYSHFIDiUfc2ixINePLzqstfG_bYe9NTHxbfKq3SZ4axJtbJPYLtn6oXtOdNck6BoMbpvEoV6h6eMJOWi1i3g6v8fk6cft0_JXev_w8255c58aQSWkrGyNAEYrLGVZVVg0ZcOxpbzkojU0r4AJiWAYN0LUBRQFoOS6ampOBRbsmFztYjdDvcbGYNcH7dQm2LUOW-W1VR-Vzr6oZ_-qgOdFxdkYcD4HBP9nwNirtY0GndMd-iGqcmxJGROj8XJnNMHHGLDdfwJUTfTVSk2I1YRYTfTVTF-9j8df_625P51xj_q3WdfRaNcG3Rkb97aKUypzOdqud7Y363D7HwXU9-XjtLG_qI6hpA</recordid><startdate>198307</startdate><enddate>198307</enddate><creator>Bryson, SM</creator><creator>Verma, N</creator><creator>Scott, PJ</creator><creator>Rubin, PC</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198307</creationdate><title>Pharmacokinetics of valproic acid in young and elderly subjects</title><author>Bryson, SM ; Verma, N ; Scott, PJ ; Rubin, PC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5061-38fc51309e86899e7d8d4ef04845fc0291356e1c34c55b71771e64a9db405e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Valproic Acid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bryson, SM</creatorcontrib><creatorcontrib>Verma, N</creatorcontrib><creatorcontrib>Scott, PJ</creatorcontrib><creatorcontrib>Rubin, PC</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bryson, SM</au><au>Verma, N</au><au>Scott, PJ</au><au>Rubin, PC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of valproic acid in young and elderly subjects</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1983-07</date><risdate>1983</risdate><volume>16</volume><issue>1</issue><spage>104</spage><epage>105</epage><pages>104-105</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>The disposition of valproic acid was studied following single dose intravenous administration in seven young male volunteers aged 20‐35 years and six elderly male in‐patients aged 75‐87 years. Following administration of 400 mg sodium valproate, blood samples were collected for 48 h and valproic acid concentrations analysed by enzymatic immunoassay. The median elimination half‐life was 7.2 h in the young subjects but 14.9 h in the elderly patients (P less than 0.01). However, clearance did not differ significantly between groups, the values for young and old being 0.69 and 0.58 1/h respectively. The prolonged half‐life resulted from a greater volume of distribution in the elderly. The median values (1/kg) for young and old were 0.13 and 0.19 respectively (P less than 0.01). These pharmacokinetic changes are unlikely to be of clinical importance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6411107</pmid><doi>10.1111/j.1365-2125.1983.tb02151.x</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1983-07, Vol.16 (1), p.104-105 |
| issn | 0306-5251 1365-2125 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1427943 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Humans Injections, Intravenous Kinetics Medical sciences Models, Biological Neuropharmacology Pharmacology. Drug treatments Valproic Acid - metabolism |
| title | Pharmacokinetics of valproic acid in young and elderly subjects |
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