Pharmacokinetic investigation of the interaction of azapropazone with phenytoin

We have investigated the interaction of azapropazone with phenytoin in five healthy volunteers. From steady‐state plasma phenytoin concentrations of about 17 mumol/l there was at least a two‐fold increase following the introduction of azapropazone. The main mechanism of the interaction was a decreas...

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Veröffentlicht in:	British journal of clinical pharmacology 1983-06, Vol.15 (6), p.727-734
Hauptverfasser:	Geaney, DP, Carver, JG, Davies, CL, Aronson, JK
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticonvulsants. Antiepileptics. Antiparkinson agents Apazone - pharmacology Biological and medical sciences Drug Interactions Humans Kinetics Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Phenytoin - analogs & derivatives Phenytoin - blood Phenytoin - metabolism Protein Binding Saliva - metabolism Triazines - pharmacology
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