Relationships among timolol doses, plasma concentrations and beta‐ adrenoceptor blocking activity

1 We investigated the relationships among dose, plasma concentration and beta‐adrenoceptor blockade after single and repeated doses (0.5‐20 mg) of timolol and placebo in six normal men. 2 Maximal suppression of exercise‐induced tachycardia (bicycle ergometry) was dose‐dependent and greater at 2 than...

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Veröffentlicht in:	British journal of clinical pharmacology 1982-11, Vol.14 (5), p.719-725
Hauptverfasser:	Ferguson, RK, Vlasses, PH, Koplin, J.R., Holmes, GI, Huber, P., Demetriades, J., Abrams, WB
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists Adult Dose-Response Relationship, Drug Heart Rate - drug effects Humans Male Physical Exertion Propanolamines - blood Renin - blood Timolol - administration & dosage Timolol - blood
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