Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria
Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types...
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| Veröffentlicht in: | Immunology 1993-08, Vol.79 (4), p.653-657 |
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| container_title | Immunology |
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| creator | JAKOBSEN, P. H MORRIS-JONES, S. D HVIID, L THEANDER, T. G HOIER-MADSEN, M BAYOUMI, R. A. L GREENWOOD, B. M |
| description | Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease. |
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H ; MORRIS-JONES, S. D ; HVIID, L ; THEANDER, T. G ; HOIER-MADSEN, M ; BAYOUMI, R. A. L ; GREENWOOD, B. M</creator><creatorcontrib>JAKOBSEN, P. H ; MORRIS-JONES, S. D ; HVIID, L ; THEANDER, T. G ; HOIER-MADSEN, M ; BAYOUMI, R. A. L ; GREENWOOD, B. M</creatorcontrib><description>Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>PMID: 8406592</identifier><identifier>CODEN: IMMUAM</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adult ; Antibodies, Antiphospholipid - blood ; Antibodies, Protozoan - blood ; Biological and medical sciences ; Cardiolipins - immunology ; Child ; Enzyme-Linked Immunosorbent Assay ; Gambia ; Human protozoal diseases ; Humans ; Immunoglobulin G - immunology ; Immunoglobulin M - immunology ; Infectious diseases ; Malaria ; Malaria, Falciparum - immunology ; Medical sciences ; Parasitic diseases ; Phosphatidylcholines - immunology ; Phosphatidylinositols - immunology ; Plasmodium falciparum ; Protozoal diseases ; Sudan</subject><ispartof>Immunology, 1993-08, Vol.79 (4), p.653-657</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421917/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421917/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3759275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8406592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JAKOBSEN, P. H</creatorcontrib><creatorcontrib>MORRIS-JONES, S. D</creatorcontrib><creatorcontrib>HVIID, L</creatorcontrib><creatorcontrib>THEANDER, T. G</creatorcontrib><creatorcontrib>HOIER-MADSEN, M</creatorcontrib><creatorcontrib>BAYOUMI, R. A. L</creatorcontrib><creatorcontrib>GREENWOOD, B. M</creatorcontrib><title>Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.</description><subject>Adult</subject><subject>Antibodies, Antiphospholipid - blood</subject><subject>Antibodies, Protozoan - blood</subject><subject>Biological and medical sciences</subject><subject>Cardiolipins - immunology</subject><subject>Child</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Gambia</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Malaria, Falciparum - immunology</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Phosphatidylcholines - immunology</subject><subject>Phosphatidylinositols - immunology</subject><subject>Plasmodium falciparum</subject><subject>Protozoal diseases</subject><subject>Sudan</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUE1LxDAQDaKs6-pPEHoQb4WkaT56EZbFL1zQg57L5KNuJG1j0yr-eyOWRQ_DzLz35s0wB2hJKGd5wbg4REuMSZUXErNjdBLjW2opZmyBFrLEnFXFEj2su9HlYdfHFN4FZzJIiOqNszFzXRZgdLYbY_bpxl325CG2iZvarAGvXYAhlS14GBycoqMERns25xV6ubl-3tzl28fb-816m4cCszEXUlJCpNCi0aywZcEra7SorFCNUkAVlVoZWQkqWckbY6Rh0nAuQTIMrKIrdPXrGybVptF03gC-DoNrYfiqe3D1f6Zzu_q1_6hJWZCKiGRwORsM_ftk41i3LmrrPXS2n2JN0m-4kD_C87-b9ivm9yX-YuYhavDNAJ12cS-jIokEo98w7Hvp</recordid><startdate>19930801</startdate><enddate>19930801</enddate><creator>JAKOBSEN, P. H</creator><creator>MORRIS-JONES, S. D</creator><creator>HVIID, L</creator><creator>THEANDER, T. G</creator><creator>HOIER-MADSEN, M</creator><creator>BAYOUMI, R. A. L</creator><creator>GREENWOOD, B. M</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>19930801</creationdate><title>Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria</title><author>JAKOBSEN, P. H ; MORRIS-JONES, S. D ; HVIID, L ; THEANDER, T. G ; HOIER-MADSEN, M ; BAYOUMI, R. A. L ; GREENWOOD, B. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p205t-78831187c7fc52e4269edc79e7bfbba3b38cbd89738546fdd8d58d668a850a593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Antibodies, Antiphospholipid - blood</topic><topic>Antibodies, Protozoan - blood</topic><topic>Biological and medical sciences</topic><topic>Cardiolipins - immunology</topic><topic>Child</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Gambia</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Malaria, Falciparum - immunology</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Phosphatidylcholines - immunology</topic><topic>Phosphatidylinositols - immunology</topic><topic>Plasmodium falciparum</topic><topic>Protozoal diseases</topic><topic>Sudan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JAKOBSEN, P. H</creatorcontrib><creatorcontrib>MORRIS-JONES, S. D</creatorcontrib><creatorcontrib>HVIID, L</creatorcontrib><creatorcontrib>THEANDER, T. G</creatorcontrib><creatorcontrib>HOIER-MADSEN, M</creatorcontrib><creatorcontrib>BAYOUMI, R. A. L</creatorcontrib><creatorcontrib>GREENWOOD, B. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JAKOBSEN, P. H</au><au>MORRIS-JONES, S. D</au><au>HVIID, L</au><au>THEANDER, T. G</au><au>HOIER-MADSEN, M</au><au>BAYOUMI, R. A. L</au><au>GREENWOOD, B. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>1993-08-01</date><risdate>1993</risdate><volume>79</volume><issue>4</issue><spage>653</spage><epage>657</epage><pages>653-657</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><coden>IMMUAM</coden><abstract>Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>8406592</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Antibodies, Antiphospholipid - blood Antibodies, Protozoan - blood Biological and medical sciences Cardiolipins - immunology Child Enzyme-Linked Immunosorbent Assay Gambia Human protozoal diseases Humans Immunoglobulin G - immunology Immunoglobulin M - immunology Infectious diseases Malaria Malaria, Falciparum - immunology Medical sciences Parasitic diseases Phosphatidylcholines - immunology Phosphatidylinositols - immunology Plasmodium falciparum Protozoal diseases Sudan |
| title | Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria |
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