Palmitic acid conjugation of a protein antigen enhances major histocompatibility complex class II-restricted presentation to T cells

The effect on antigenicity of covalent attachment of lipid groups to a protein antigen was investigated. Coupling of palmitic acid to ovalbumin (OVA) enhanced major histocompatibility complex (MHC) class II-restricted presentation to most OVA-specific murine T-cell clones in vitro. The enhanced anti...

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Veröffentlicht in:	Immunology 1992-08, Vol.76 (4), p.593-598
Hauptverfasser:	ROBINSON, J. H, CASE, M. C, BROOKS, C. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Animals Antigen-Presenting Cells - immunology Antigenic determinants, haptens, artificial antigens Antigens Biological and medical sciences Cell Division - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility Antigens Class II - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Molecular immunology Ovalbumin - immunology Palmitic Acid Palmitic Acids - immunology T-Lymphocytes - immunology
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