Somatic control of germline sexual development is mediated by the JAK/STAT pathway

Germ cells must develop along distinct male or female paths to produce the sperm or eggs required for sexual reproduction. In both mouse and Drosophila , the sexual identity of germ cells is influenced by the sex of the surrounding somatic tissue (for example, refs 1 , 2 , reviewed in refs 3 , 4 );...

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Veröffentlicht in:	Nature (London) 2005-07, Vol.436 (7050), p.563-567
Hauptverfasser:	Wawersik, Matthew, Milutinovich, Allison, Casper, Abbie L., Matunis, Erika, Williams, Brian, Van Doren, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal reproduction Animals Biological and medical sciences Cell Division DNA-Binding Proteins - metabolism Drosophila melanogaster - cytology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism Embryology: invertebrates and vertebrates. Teratology Enzyme Activation Female Females Fundamental and applied biological sciences. Psychology Germ Cells - cytology Germ Cells - metabolism Gonads Humanities and Social Sciences In Situ Hybridization Insects Janus Kinase 1 Larva - cytology Larva - metabolism letter Male Medical research multidisciplinary Mutation - genetics Organogenesis. Fetal development Organogenesis. Physiological fonctions Protein-Tyrosine Kinases - metabolism Reproductive system RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Science Sex Characteristics Sex Differentiation Signal Transduction STAT Transcription Factors Trans-Activators - metabolism
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