Survival of patients evaluated by FDG-PET before hepatic resection for metastatic colorectal carcinoma : A prospective database study
To present the survival results for patients with colorectal carcinoma metastases who have undergone liver resection after being staged by [(18)F] fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET). Hepatic resection is standard therapy for colorectal metastases confined to the liver, b...
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| Veröffentlicht in: | Annals of surgery 2001-03, Vol.233 (3), p.293-299 |
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| creator | STRASBERG, Steven M DEHDASHTI, Farrokh SIEGEL, Barry A DREBIN, Jeffrey A LINEHAN, David |
| description | To present the survival results for patients with colorectal carcinoma metastases who have undergone liver resection after being staged by [(18)F] fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET).
Hepatic resection is standard therapy for colorectal metastases confined to the liver, but recurrence is common because of the presence of undetected cancer at the time of surgery. FDG-PET is a sensitive diagnostic tool that identifies tumors based on the increased uptake of glucose by tumor cells. To date, no survival results have been reported for patients who have actually had liver resection after being staged by FDG-PET.
Forty-three patients with metastatic colorectal cancer were referred for hepatic resection after conventional tumor staging with computed tomography. FDG-PET was performed on all patients. Laparotomy was performed on patients not staged out by PET. Resection was performed at the time of laparotomy unless extrahepatic disease or unresectable hepatic tumors were found. Patients were examined at intervals in the preoperative period.
FDG-PET identified additional cancer not seen on computed tomography in 10 patients. Surgery was contraindicated in six of these patients because of the findings on FDG-PET. Laparotomy was performed in 37 patients. In all but two, liver resection was performed. Median follow-up in the 35 patients undergoing resection was 24 months. The Kaplan-Meier estimate of overall survival at 3 years was 77% and the lower 95% confidence limit of this estimate of survival was 60%. This figure is higher than 3-year estimate of survival found in previously published series. The 3-year disease-free survival rate was 40%.
Preoperative FDG-PET lessens the recurrence rate in patients undergoing hepatic resection for colorectal metastases to the liver by detection of disease not found on conventional imaging. |
| doi_str_mv | 10.1097/00000658-200103000-00001 |
| format | Article |
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Hepatic resection is standard therapy for colorectal metastases confined to the liver, but recurrence is common because of the presence of undetected cancer at the time of surgery. FDG-PET is a sensitive diagnostic tool that identifies tumors based on the increased uptake of glucose by tumor cells. To date, no survival results have been reported for patients who have actually had liver resection after being staged by FDG-PET.
Forty-three patients with metastatic colorectal cancer were referred for hepatic resection after conventional tumor staging with computed tomography. FDG-PET was performed on all patients. Laparotomy was performed on patients not staged out by PET. Resection was performed at the time of laparotomy unless extrahepatic disease or unresectable hepatic tumors were found. Patients were examined at intervals in the preoperative period.
FDG-PET identified additional cancer not seen on computed tomography in 10 patients. Surgery was contraindicated in six of these patients because of the findings on FDG-PET. Laparotomy was performed in 37 patients. In all but two, liver resection was performed. Median follow-up in the 35 patients undergoing resection was 24 months. The Kaplan-Meier estimate of overall survival at 3 years was 77% and the lower 95% confidence limit of this estimate of survival was 60%. This figure is higher than 3-year estimate of survival found in previously published series. The 3-year disease-free survival rate was 40%.
Preoperative FDG-PET lessens the recurrence rate in patients undergoing hepatic resection for colorectal metastases to the liver by detection of disease not found on conventional imaging.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/00000658-200103000-00001</identifier><identifier>PMID: 11224615</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma - diagnostic imaging ; Carcinoma - mortality ; Carcinoma - secondary ; Colorectal Neoplasms - diagnostic imaging ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Databases, Factual ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18 ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Missouri - epidemiology ; Neoplasm Staging - methods ; Prospective Studies ; Radiopharmaceuticals ; Sensitivity and Specificity ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Rate ; Tomography, Emission-Computed - methods ; Tumors</subject><ispartof>Annals of surgery, 2001-03, Vol.233 (3), p.293-299</ispartof><rights>2001 INIST-CNRS</rights><rights>2001 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-cf6f7539fa4d52c9b2a1a3baed7a06ea0d05764bedfbbae59c3d8751f9c5611f3</citedby><cites>FETCH-LOGICAL-c539t-cf6f7539fa4d52c9b2a1a3baed7a06ea0d05764bedfbbae59c3d8751f9c5611f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421243/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421243/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=909031$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11224615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>STRASBERG, Steven M</creatorcontrib><creatorcontrib>DEHDASHTI, Farrokh</creatorcontrib><creatorcontrib>SIEGEL, Barry A</creatorcontrib><creatorcontrib>DREBIN, Jeffrey A</creatorcontrib><creatorcontrib>LINEHAN, David</creatorcontrib><title>Survival of patients evaluated by FDG-PET before hepatic resection for metastatic colorectal carcinoma : A prospective database study</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>To present the survival results for patients with colorectal carcinoma metastases who have undergone liver resection after being staged by [(18)F] fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET).
Hepatic resection is standard therapy for colorectal metastases confined to the liver, but recurrence is common because of the presence of undetected cancer at the time of surgery. FDG-PET is a sensitive diagnostic tool that identifies tumors based on the increased uptake of glucose by tumor cells. To date, no survival results have been reported for patients who have actually had liver resection after being staged by FDG-PET.
Forty-three patients with metastatic colorectal cancer were referred for hepatic resection after conventional tumor staging with computed tomography. FDG-PET was performed on all patients. Laparotomy was performed on patients not staged out by PET. Resection was performed at the time of laparotomy unless extrahepatic disease or unresectable hepatic tumors were found. Patients were examined at intervals in the preoperative period.
FDG-PET identified additional cancer not seen on computed tomography in 10 patients. Surgery was contraindicated in six of these patients because of the findings on FDG-PET. Laparotomy was performed in 37 patients. In all but two, liver resection was performed. Median follow-up in the 35 patients undergoing resection was 24 months. The Kaplan-Meier estimate of overall survival at 3 years was 77% and the lower 95% confidence limit of this estimate of survival was 60%. This figure is higher than 3-year estimate of survival found in previously published series. The 3-year disease-free survival rate was 40%.
Preoperative FDG-PET lessens the recurrence rate in patients undergoing hepatic resection for colorectal metastases to the liver by detection of disease not found on conventional imaging.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - secondary</subject><subject>Colorectal Neoplasms - diagnostic imaging</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Databases, Factual</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Missouri - epidemiology</subject><subject>Neoplasm Staging - methods</subject><subject>Prospective Studies</subject><subject>Radiopharmaceuticals</subject><subject>Sensitivity and Specificity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Rate</subject><subject>Tomography, Emission-Computed - methods</subject><subject>Tumors</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd1u1DAQhS0EosvCKyBLSNwFPHF-uUCqSluQKlGp5dqaOGNqlMTBdlbaB-C9cdplaX1j-_ib4xkdxjiIDyDa-qNYV1U2WS4ECJku2arAM7aBMm8ygEI8Z5skyaxoZX7CXoXwKwFFI-qX7AQgz4sKyg37c7P4nd3hwJ3hM0ZLUwyckrBgpJ53e37x5TK7Pr_lHRnnid_RimnuKZCO1k08yXykiCHeP2g3JE7H5KnRazu5Efknfspn78K81uyI9xixw0A8xKXfv2YvDA6B3hz2LftxcX579jW7-n757ez0KtOlbGOmTWXqdDJY9GWu2y5HQNkh9TWKilD0oqyroqPedEktWy37pi7BtLqsAIzcss8PvvPSjdTrNKzHQc3ejuj3yqFVT18me6d-up2CIoe8kMng_cHAu98LhahGGzQNA07klqDqlIooUo9b1jyAOg0dPJnjJyDUmqH6l6E6ZngvQSp9-7jJ_4WH0BLw7gBg0DgYj5O24ci1ohUS5F-O6afZ</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>STRASBERG, Steven M</creator><creator>DEHDASHTI, Farrokh</creator><creator>SIEGEL, Barry A</creator><creator>DREBIN, Jeffrey A</creator><creator>LINEHAN, David</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010301</creationdate><title>Survival of patients evaluated by FDG-PET before hepatic resection for metastatic colorectal carcinoma : A prospective database study</title><author>STRASBERG, Steven M ; DEHDASHTI, Farrokh ; SIEGEL, Barry A ; DREBIN, Jeffrey A ; LINEHAN, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-cf6f7539fa4d52c9b2a1a3baed7a06ea0d05764bedfbbae59c3d8751f9c5611f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - secondary</topic><topic>Colorectal Neoplasms - diagnostic imaging</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Databases, Factual</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Missouri - epidemiology</topic><topic>Neoplasm Staging - methods</topic><topic>Prospective Studies</topic><topic>Radiopharmaceuticals</topic><topic>Sensitivity and Specificity</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Rate</topic><topic>Tomography, Emission-Computed - methods</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>STRASBERG, Steven M</creatorcontrib><creatorcontrib>DEHDASHTI, Farrokh</creatorcontrib><creatorcontrib>SIEGEL, Barry A</creatorcontrib><creatorcontrib>DREBIN, Jeffrey A</creatorcontrib><creatorcontrib>LINEHAN, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>STRASBERG, Steven M</au><au>DEHDASHTI, Farrokh</au><au>SIEGEL, Barry A</au><au>DREBIN, Jeffrey A</au><au>LINEHAN, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of patients evaluated by FDG-PET before hepatic resection for metastatic colorectal carcinoma : A prospective database study</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>233</volume><issue>3</issue><spage>293</spage><epage>299</epage><pages>293-299</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><coden>ANSUA5</coden><abstract>To present the survival results for patients with colorectal carcinoma metastases who have undergone liver resection after being staged by [(18)F] fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET).
Hepatic resection is standard therapy for colorectal metastases confined to the liver, but recurrence is common because of the presence of undetected cancer at the time of surgery. FDG-PET is a sensitive diagnostic tool that identifies tumors based on the increased uptake of glucose by tumor cells. To date, no survival results have been reported for patients who have actually had liver resection after being staged by FDG-PET.
Forty-three patients with metastatic colorectal cancer were referred for hepatic resection after conventional tumor staging with computed tomography. FDG-PET was performed on all patients. Laparotomy was performed on patients not staged out by PET. Resection was performed at the time of laparotomy unless extrahepatic disease or unresectable hepatic tumors were found. Patients were examined at intervals in the preoperative period.
FDG-PET identified additional cancer not seen on computed tomography in 10 patients. Surgery was contraindicated in six of these patients because of the findings on FDG-PET. Laparotomy was performed in 37 patients. In all but two, liver resection was performed. Median follow-up in the 35 patients undergoing resection was 24 months. The Kaplan-Meier estimate of overall survival at 3 years was 77% and the lower 95% confidence limit of this estimate of survival was 60%. This figure is higher than 3-year estimate of survival found in previously published series. The 3-year disease-free survival rate was 40%.
Preoperative FDG-PET lessens the recurrence rate in patients undergoing hepatic resection for colorectal metastases to the liver by detection of disease not found on conventional imaging.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>11224615</pmid><doi>10.1097/00000658-200103000-00001</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; PubMed Central |
| subjects | Aged Biological and medical sciences Carcinoma - diagnostic imaging Carcinoma - mortality Carcinoma - secondary Colorectal Neoplasms - diagnostic imaging Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Databases, Factual Disease-Free Survival Female Fluorodeoxyglucose F18 Gastroenterology. Liver. Pancreas. Abdomen Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - mortality Liver Neoplasms - secondary Liver Neoplasms - surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Missouri - epidemiology Neoplasm Staging - methods Prospective Studies Radiopharmaceuticals Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Rate Tomography, Emission-Computed - methods Tumors |
| title | Survival of patients evaluated by FDG-PET before hepatic resection for metastatic colorectal carcinoma : A prospective database study |
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