Detection of familial dysalbuminaemic hyperthyroxinaemia
A simple test of in vitro thyroxine binding to serum proteins was used to screen serum samples from euthyroid patients with unexplained increases in the free thyroxine index. A diagnosis of familial dysalbuminaemic hyperthyroxinaemia was presumed in 14 unrelated subjects and six first degree relativ...
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| Veröffentlicht in: | BMJ 1985-04, Vol.290 (6475), p.1099-1102 |
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| creator | Croxson, M S Palmer, B N Holdaway, I M Frengley, P A Evans, M C |
| description | A simple test of in vitro thyroxine binding to serum proteins was used to screen serum samples from euthyroid patients with unexplained increases in the free thyroxine index. A diagnosis of familial dysalbuminaemic hyperthyroxinaemia was presumed in 14 unrelated subjects and six first degree relatives. Increased binding of thyroxine to thyroxine binding prealbumin was diagnosed in one woman with four unaffected relatives. Seven patients with familial dysalbuminaemic hyperthyroxinaemia had been treated for presumed thyrotoxicosis: two had typical Graves' disease and one subacute thyroiditis. Four other patients had been mistakenly treated with radioactive iodine or antithyroid drugs. In previously treated patients familial dysalbuminaemic hyperthyroxinaemia was suspected from the combination of a high serum thyroid stimulating hormone concentration and a normal but invalid free thyroxine index. Physicians should be cautious in accepting a diagnosis of thyrotoxicosis based mainly on a raised serum thyroxine concentration. |
| doi_str_mv | 10.1136/bmj.290.6475.1099 |
| format | Article |
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A diagnosis of familial dysalbuminaemic hyperthyroxinaemia was presumed in 14 unrelated subjects and six first degree relatives. Increased binding of thyroxine to thyroxine binding prealbumin was diagnosed in one woman with four unaffected relatives. Seven patients with familial dysalbuminaemic hyperthyroxinaemia had been treated for presumed thyrotoxicosis: two had typical Graves' disease and one subacute thyroiditis. Four other patients had been mistakenly treated with radioactive iodine or antithyroid drugs. In previously treated patients familial dysalbuminaemic hyperthyroxinaemia was suspected from the combination of a high serum thyroid stimulating hormone concentration and a normal but invalid free thyroxine index. 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A diagnosis of familial dysalbuminaemic hyperthyroxinaemia was presumed in 14 unrelated subjects and six first degree relatives. Increased binding of thyroxine to thyroxine binding prealbumin was diagnosed in one woman with four unaffected relatives. Seven patients with familial dysalbuminaemic hyperthyroxinaemia had been treated for presumed thyrotoxicosis: two had typical Graves' disease and one subacute thyroiditis. Four other patients had been mistakenly treated with radioactive iodine or antithyroid drugs. In previously treated patients familial dysalbuminaemic hyperthyroxinaemia was suspected from the combination of a high serum thyroid stimulating hormone concentration and a normal but invalid free thyroxine index. Physicians should be cautious in accepting a diagnosis of thyrotoxicosis based mainly on a raised serum thyroxine concentration.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Albumins</subject><subject>Antithyroid agents</subject><subject>Clinical Research</subject><subject>Diagnostic indices</subject><subject>Female</subject><subject>Graves disease</subject><subject>Graves Disease - blood</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hyperthyroidism - blood</subject><subject>Hypothyroidism</subject><subject>Iodine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Serum Albumin - genetics</subject><subject>Serum Albumin - metabolism</subject><subject>Symptoms</subject><subject>Thyroid diseases</subject><subject>Thyrotoxicosis</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Thyroxine - genetics</subject><subject>Thyroxine-Binding Proteins - metabolism</subject><subject>Triiodothyronine - blood</subject><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkV1rFDEYhYNY6lL7A7wQFgSvnDXfmdwIsmoVl4q2eBuSTOJmnZmsyYx0_70ZZlmtN71KyDnnzXl5AHiG4Aohwl-bbrfCEq44FWyFoJSPwAJRXlesJuQxWEDMRQU5Jk_AZc47CCEmopacnoNzIjFCmCxA_c4Nzg4h9svol153oQ26XTaHrFszdqHXrgt2uT3sXRq2hxTv5if9FJx53WZ3eTwvwO2H97frj9Xmy9Wn9dtNZRiEskJGWEG90UgK7HBDoDWsZsJYx5x23DeeGWgZsYhAWW6UskZ7iKQ33mlyAd7MY_ej6VxjXT8k3ap9Cp1OBxV1UPeVPmzVj_hbIYpqQWgZ8PI4IMVfo8uD6kK2rm117-KYleCQ0xrBYnzxn3EXx9SX3RQSgpdehPHiQrPLpphzcv5UBUE1YVEFiypY1IRFTVhK5vm_O5wSRwh_9V0eYjrJWDJU12LKV7Me8uDuTrpOPxUXpPxy_X2tNjf46tvXz0TdFP-r2T9VebjeH9a1sOI</recordid><startdate>19850413</startdate><enddate>19850413</enddate><creator>Croxson, M S</creator><creator>Palmer, B N</creator><creator>Holdaway, I M</creator><creator>Frengley, P A</creator><creator>Evans, M C</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19850413</creationdate><title>Detection of familial dysalbuminaemic hyperthyroxinaemia</title><author>Croxson, M S ; Palmer, B N ; Holdaway, I M ; Frengley, P A ; Evans, M C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b5009-1b7c74fba1972e2d30cb5857bce5eae6fdf5b0c53c1309b0c445daf019fbfea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Albumins</topic><topic>Antithyroid agents</topic><topic>Clinical Research</topic><topic>Diagnostic indices</topic><topic>Female</topic><topic>Graves disease</topic><topic>Graves Disease - blood</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hyperthyroidism - blood</topic><topic>Hypothyroidism</topic><topic>Iodine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Serum Albumin - genetics</topic><topic>Serum Albumin - metabolism</topic><topic>Symptoms</topic><topic>Thyroid diseases</topic><topic>Thyrotoxicosis</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Thyroxine - genetics</topic><topic>Thyroxine-Binding Proteins - metabolism</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Croxson, M S</creatorcontrib><creatorcontrib>Palmer, B N</creatorcontrib><creatorcontrib>Holdaway, I M</creatorcontrib><creatorcontrib>Frengley, P A</creatorcontrib><creatorcontrib>Evans, M C</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Croxson, M S</au><au>Palmer, B N</au><au>Holdaway, I M</au><au>Frengley, P A</au><au>Evans, M C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of familial dysalbuminaemic hyperthyroxinaemia</atitle><jtitle>BMJ</jtitle><addtitle>Br Med J (Clin Res Ed)</addtitle><date>1985-04-13</date><risdate>1985</risdate><volume>290</volume><issue>6475</issue><spage>1099</spage><epage>1102</epage><pages>1099-1102</pages><issn>0267-0623</issn><issn>0959-8138</issn><eissn>1468-5833</eissn><abstract>A simple test of in vitro thyroxine binding to serum proteins was used to screen serum samples from euthyroid patients with unexplained increases in the free thyroxine index. A diagnosis of familial dysalbuminaemic hyperthyroxinaemia was presumed in 14 unrelated subjects and six first degree relatives. Increased binding of thyroxine to thyroxine binding prealbumin was diagnosed in one woman with four unaffected relatives. Seven patients with familial dysalbuminaemic hyperthyroxinaemia had been treated for presumed thyrotoxicosis: two had typical Graves' disease and one subacute thyroiditis. Four other patients had been mistakenly treated with radioactive iodine or antithyroid drugs. In previously treated patients familial dysalbuminaemic hyperthyroxinaemia was suspected from the combination of a high serum thyroid stimulating hormone concentration and a normal but invalid free thyroxine index. Physicians should be cautious in accepting a diagnosis of thyrotoxicosis based mainly on a raised serum thyroxine concentration.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>3921123</pmid><doi>10.1136/bmj.290.6475.1099</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0267-0623 |
| ispartof | BMJ, 1985-04, Vol.290 (6475), p.1099-1102 |
| issn | 0267-0623 0959-8138 1468-5833 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Adolescent Adult Aged Albumins Antithyroid agents Clinical Research Diagnostic indices Female Graves disease Graves Disease - blood Hormones Humans Hyperthyroidism - blood Hypothyroidism Iodine Male Middle Aged Serum Albumin - genetics Serum Albumin - metabolism Symptoms Thyroid diseases Thyrotoxicosis Thyrotropin - blood Thyroxine - blood Thyroxine - genetics Thyroxine-Binding Proteins - metabolism Triiodothyronine - blood |
| title | Detection of familial dysalbuminaemic hyperthyroxinaemia |
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