Brain shrinkage in chronic alcoholics: a pathological study
A quantitative neuropathological necropsy study of 22 control and 22 chronic alcoholic subjects showed a statistically significant loss of brain tissue in the chronic alcoholic group. The loss of tissue appeared to be from the white matter of the cerebral hemispheres rather than the cerebral cortex....
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| Veröffentlicht in: | BMJ 1985-02, Vol.290 (6467), p.501-504 |
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| creator | Harper, C G Kril, J J Holloway, R L |
| description | A quantitative neuropathological necropsy study of 22 control and 22 chronic alcoholic subjects showed a statistically significant loss of brain tissue in the chronic alcoholic group. The loss of tissue appeared to be from the white matter of the cerebral hemispheres rather than the cerebral cortex. This may reflect a primary alteration in the composition or structure of the white matter or it may be secondary to loss of nerve cells from the cortex with subsequent degeneration of the axons in the white matter. Further morphometric analyses including cortical neuronal counts will be necessary to clarify this issue. |
| doi_str_mv | 10.1136/bmj.290.6467.501 |
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The loss of tissue appeared to be from the white matter of the cerebral hemispheres rather than the cerebral cortex. This may reflect a primary alteration in the composition or structure of the white matter or it may be secondary to loss of nerve cells from the cortex with subsequent degeneration of the axons in the white matter. 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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Adolescent Adult Aged Alcohol related disorders Alcoholism Alcoholism - pathology Basal ganglia Basal Ganglia - pathology Brain Brain - pathology Cerebral Cortex - pathology Cerebral hemispheres Cerebral Ventricles - pathology Clinical Research Female Gray matter Humans Male Middle Aged Neurons Organ Size Pathology Sex Factors Volume White matter |
| title | Brain shrinkage in chronic alcoholics: a pathological study |
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