Progesterone and the premenstrual syndrome: a double blind crossover trial
A double blind, randomised, crossover trial of oral micronised progesterone (two months) and placebo (two months) was conducted to determine whether progesterone alleviated premenstrual complaints. Twenty three women were interviewed premenstrually before treatment and in each month of treatment. Th...
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| Veröffentlicht in: | BMJ 1985-06, Vol.290 (6482), p.1617-1621 |
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| creator | Dennerstein, L Spencer-Gardner, C Gotts, G Brown, J B Smith, M A Burrows, G D |
| description | A double blind, randomised, crossover trial of oral micronised progesterone (two months) and placebo (two months) was conducted to determine whether progesterone alleviated premenstrual complaints. Twenty three women were interviewed premenstrually before treatment and in each month of treatment. They completed Moos's menstrual distress questionnaire, Beck et al's depression inventory, Spielberger et al's state anxiety inventory, the mood adjective checklist, and a daily symptom record. Analyses of data found an overall beneficial effect of being treated for all variables except restlessness, positive moods, and interest in sex. Maximum improvement occurred in the first month of treatment with progesterone. Nevertheless, an appreciably beneficial effect of progesterone over placebo for mood and some physical symptoms was identifiable after both one and two months of treatment. Further studies are needed to determine the optimum duration of treatment. |
| doi_str_mv | 10.1136/bmj.290.6482.1617 |
| format | Article |
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Twenty three women were interviewed premenstrually before treatment and in each month of treatment. They completed Moos's menstrual distress questionnaire, Beck et al's depression inventory, Spielberger et al's state anxiety inventory, the mood adjective checklist, and a daily symptom record. Analyses of data found an overall beneficial effect of being treated for all variables except restlessness, positive moods, and interest in sex. Maximum improvement occurred in the first month of treatment with progesterone. Nevertheless, an appreciably beneficial effect of progesterone over placebo for mood and some physical symptoms was identifiable after both one and two months of treatment. 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Further studies are needed to determine the optimum duration of treatment.</description><subject>Adjectives</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Anxiety</subject><subject>Clinical Trials as Topic</subject><subject>Depressive disorders</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Menstrual cycle</subject><subject>Middle Aged</subject><subject>Placebos</subject><subject>Premenstrual syndrome</subject><subject>Premenstrual Syndrome - drug therapy</subject><subject>Progesterone - adverse effects</subject><subject>Progesterone - therapeutic use</subject><subject>Questionnaires</subject><subject>Random Allocation</subject><subject>Side effects</subject><subject>Symptoms</subject><subject>T tests</subject><issn>0267-0623</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtP3DAUhS0EoiPgB3SBFKlbMvj67S4q0RGPVggqlXZrOYkDmSbx1E4Q_HuczmgKK1ZenHOPv3sPQh8BzwGoOC265ZxoPBdMkTkIkDtoBkyonCtKd9EMEyFzLAj9gI5iXGKMCZVKC7aP9qkmDDTM0Pcfwd-7OLjge5fZvsqGB5etgutcH4cw2jaLz30VfOc-Zzar_Fi0LivaJjnL4GP0jy5kQ2hse4j2attGd7R5D9Cvi_O7xVV-fXv5bXF2nRdMiiEnFnhZYyokq-rallgnMqq51rzWFERBCqu0VE5QZklVOVZSopTAHBNuuaYH6Ms6dzUWnatK1w_BtmYVms6GZ-NtY94qffNg7v2jAQZcgUgBnzYBwf8d0_Jm6cfQJ2YDUgqWbshocsHa9W_N4OrtD4DNVIBJBZhUgJkKMFMBaeb4Ndp2YnPu__oyDj5sZaI5aComsnytN6mRp61uwx8jJJXc3PxemMuv_E4tNDU_k_9k7Z9Q3sd7Aa-Lp-A</recordid><startdate>19850601</startdate><enddate>19850601</enddate><creator>Dennerstein, L</creator><creator>Spencer-Gardner, C</creator><creator>Gotts, G</creator><creator>Brown, J B</creator><creator>Smith, M A</creator><creator>Burrows, G D</creator><general>British Medical Journal Publishing Group</general><general>British Medical Association</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>19850601</creationdate><title>Progesterone and the premenstrual syndrome: a double blind crossover trial</title><author>Dennerstein, L ; 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| identifier | ISSN: 0267-0623 |
| ispartof | BMJ, 1985-06, Vol.290 (6482), p.1617-1621 |
| issn | 0267-0623 0959-8138 1468-5833 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Adjectives Adolescent Adult Anxiety Clinical Trials as Topic Depressive disorders Double-Blind Method Female Humans Menstrual cycle Middle Aged Placebos Premenstrual syndrome Premenstrual Syndrome - drug therapy Progesterone - adverse effects Progesterone - therapeutic use Questionnaires Random Allocation Side effects Symptoms T tests |
| title | Progesterone and the premenstrual syndrome: a double blind crossover trial |
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