Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers

The transcription factor NFATc1 may be involved in slow skeletal muscle gene expression. NFATc1 translocates from cytoplasm to nuclei during slow fiber type electrical stimulation of skeletal muscle fibers because of activation of the Ca(2+)-dependent phosphatase calcineurin, resulting in nuclear fa...

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Veröffentlicht in:	Molecular biology of the cell 2006-04, Vol.17 (4), p.1570-1582
Hauptverfasser:	Shen, Tiansheng, Liu, Yewei, Cseresnyés, Zoltán, Hawkins, Arie, Randall, William R, Schneider, Martin F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcineurin - metabolism Calcineurin Inhibitors Casein Kinase I - antagonists & inhibitors Casein Kinase I - metabolism Cell Nucleus - chemistry Cell Nucleus - metabolism Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Cytoplasm - chemistry Cytoplasm - metabolism Electric Stimulation Fatty Acids, Unsaturated - pharmacology Humans Intranuclear Inclusion Bodies - chemistry Mice Mice, Inbred Strains Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - physiology Muscle, Skeletal - metabolism Muscle, Skeletal - physiology NFATC Transcription Factors - analysis NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Protein Kinase Inhibitors - pharmacology Protein Transport - drug effects
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