Isolation of two minigastrins from Zollinger-Ellison tumour tissue
A pair of gastrin tridecapeptides (`minigastrins') have been isolated from Zollinger-Ellison tumour tissue; they correspond to the fragment 5-17 of the heptadecapeptides isolated from the same source. In one (type II) the tyrosine residue present is sulphated, in the other (type I) it is not. T...
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| Veröffentlicht in: | Gut 1974-09, Vol.15 (9), p.683-685 |
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| creator | Gregory, R. A. Tracy, Hilda J. |
| description | A pair of gastrin tridecapeptides (`minigastrins') have been isolated from Zollinger-Ellison tumour tissue; they correspond to the fragment 5-17 of the heptadecapeptides isolated from the same source. In one (type II) the tyrosine residue present is sulphated, in the other (type I) it is not. The proportion of types I and II is approximately 2:1 similar to that for the `big' gastrins and the heptadecapeptides isolated from the same source and from human antral mucosa. Both minigastrins are potent stimulants of gastric acid secretion. Immunological evidence exists to indicate that both are present as circulating forms of the hormone gastrin in patients with the Zollinger-Ellison syndrome and in fed normal subjects. |
| doi_str_mv | 10.1136/gut.15.9.683 |
| format | Article |
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A. ; Tracy, Hilda J.</creator><creatorcontrib>Gregory, R. A. ; Tracy, Hilda J.</creatorcontrib><description>A pair of gastrin tridecapeptides (`minigastrins') have been isolated from Zollinger-Ellison tumour tissue; they correspond to the fragment 5-17 of the heptadecapeptides isolated from the same source. In one (type II) the tyrosine residue present is sulphated, in the other (type I) it is not. The proportion of types I and II is approximately 2:1 similar to that for the `big' gastrins and the heptadecapeptides isolated from the same source and from human antral mucosa. Both minigastrins are potent stimulants of gastric acid secretion. Immunological evidence exists to indicate that both are present as circulating forms of the hormone gastrin in patients with the Zollinger-Ellison syndrome and in fed normal subjects.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.15.9.683</identifier><identifier>PMID: 4435581</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Amino Acids - analysis ; Chromatography ; Chromatography, Gel ; Gastrins - immunology ; Gastrins - isolation & purification ; Humans ; Liver Neoplasms - analysis ; Molecular Weight ; Neoplasm Metastasis ; Neoplasm Proteins - analysis ; Peptide Fragments - isolation & purification ; Peptides - analysis ; Zollinger-Ellison Syndrome - immunology ; Zollinger-Ellison Syndrome - metabolism</subject><ispartof>Gut, 1974-09, Vol.15 (9), p.683-685</ispartof><rights>Copyright BMJ Publishing Group LTD Sep 1974</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3613-5e0689490df201f3b5d085790de05b17548f888e5dbae3b0cfbb59423ba0bcc63</citedby><cites>FETCH-LOGICAL-b3613-5e0689490df201f3b5d085790de05b17548f888e5dbae3b0cfbb59423ba0bcc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413047/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413047/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4435581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gregory, R. A.</creatorcontrib><creatorcontrib>Tracy, Hilda J.</creatorcontrib><title>Isolation of two minigastrins from Zollinger-Ellison tumour tissue</title><title>Gut</title><addtitle>Gut</addtitle><description>A pair of gastrin tridecapeptides (`minigastrins') have been isolated from Zollinger-Ellison tumour tissue; they correspond to the fragment 5-17 of the heptadecapeptides isolated from the same source. In one (type II) the tyrosine residue present is sulphated, in the other (type I) it is not. The proportion of types I and II is approximately 2:1 similar to that for the `big' gastrins and the heptadecapeptides isolated from the same source and from human antral mucosa. Both minigastrins are potent stimulants of gastric acid secretion. Immunological evidence exists to indicate that both are present as circulating forms of the hormone gastrin in patients with the Zollinger-Ellison syndrome and in fed normal subjects.</description><subject>Amino Acids - analysis</subject><subject>Chromatography</subject><subject>Chromatography, Gel</subject><subject>Gastrins - immunology</subject><subject>Gastrins - isolation & purification</subject><subject>Humans</subject><subject>Liver Neoplasms - analysis</subject><subject>Molecular Weight</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Proteins - analysis</subject><subject>Peptide Fragments - isolation & purification</subject><subject>Peptides - analysis</subject><subject>Zollinger-Ellison Syndrome - immunology</subject><subject>Zollinger-Ellison Syndrome - metabolism</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1974</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kM1PGzEQxS3UCsLHjWullXrgwqbj-PtSqURAkRBcIAculr3xpg67a2p7Kf3va5Qoai89zYzeT29mHkKnGKYYE_5lNeYpZlM15ZLsoQmmXNZkJuUHNAHAomaCqgN0mNIaAKRUeB_tU0oYk3iCLm5S6Ez2YahCW-Vfoer94Fcm5eiHVLUx9NVT6Do_rFysL0uTCprHPoyxyj6l0R2jj63pkjvZ1iP0eHX5MP9e395f38y_3daWcExq5oBLRRUs2xnglli2BMlEmR0wiwWjspVSOra0xhELTWstU3RGrAHbNJwcoa8b35fR9m7ZuCFH0-mX6HsTf-tgvP5XGfwPvQqvGlNMgIpi8HlrEMPP0aWs1-WLodyssRAAVCkOhTrfUE0MKUXX7jZg0O-B6xK4xkwrXQIv-Ke_r9rB24SLXm90n7J728kmPmsuiGD6bjHX88WCKz670HeFP9vwtl__f_Mfz0KZCA</recordid><startdate>19740901</startdate><enddate>19740901</enddate><creator>Gregory, R. 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A. ; Tracy, Hilda J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3613-5e0689490df201f3b5d085790de05b17548f888e5dbae3b0cfbb59423ba0bcc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1974</creationdate><topic>Amino Acids - analysis</topic><topic>Chromatography</topic><topic>Chromatography, Gel</topic><topic>Gastrins - immunology</topic><topic>Gastrins - isolation & purification</topic><topic>Humans</topic><topic>Liver Neoplasms - analysis</topic><topic>Molecular Weight</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Proteins - analysis</topic><topic>Peptide Fragments - isolation & purification</topic><topic>Peptides - analysis</topic><topic>Zollinger-Ellison Syndrome - immunology</topic><topic>Zollinger-Ellison Syndrome - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gregory, R. A.</creatorcontrib><creatorcontrib>Tracy, Hilda J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gregory, R. A.</au><au>Tracy, Hilda J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isolation of two minigastrins from Zollinger-Ellison tumour tissue</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1974-09-01</date><risdate>1974</risdate><volume>15</volume><issue>9</issue><spage>683</spage><epage>685</epage><pages>683-685</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>A pair of gastrin tridecapeptides (`minigastrins') have been isolated from Zollinger-Ellison tumour tissue; they correspond to the fragment 5-17 of the heptadecapeptides isolated from the same source. In one (type II) the tyrosine residue present is sulphated, in the other (type I) it is not. The proportion of types I and II is approximately 2:1 similar to that for the `big' gastrins and the heptadecapeptides isolated from the same source and from human antral mucosa. Both minigastrins are potent stimulants of gastric acid secretion. Immunological evidence exists to indicate that both are present as circulating forms of the hormone gastrin in patients with the Zollinger-Ellison syndrome and in fed normal subjects.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>4435581</pmid><doi>10.1136/gut.15.9.683</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acids - analysis Chromatography Chromatography, Gel Gastrins - immunology Gastrins - isolation & purification Humans Liver Neoplasms - analysis Molecular Weight Neoplasm Metastasis Neoplasm Proteins - analysis Peptide Fragments - isolation & purification Peptides - analysis Zollinger-Ellison Syndrome - immunology Zollinger-Ellison Syndrome - metabolism |
| title | Isolation of two minigastrins from Zollinger-Ellison tumour tissue |
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