Excitatory effects of adrenaline upon isolated preparations of human colon
The effect of beta-adrenergic blockade with oxprenolol upon adrenaline-induced relaxation of strips of human sigmoid colon was investigated. Following blockade of beta-adrenoceptors with oxprenolol, adrenaline evoked dose-dependent contractions of both longitudinal and circular muscle strips. Storag...
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| Veröffentlicht in: | Gut 1972-08, Vol.13 (8), p.654-657 |
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| creator | Gagnon, D. J. Devroede, G. Belisle, S. |
| description | The effect of beta-adrenergic blockade with oxprenolol upon adrenaline-induced relaxation of strips of human sigmoid colon was investigated. Following blockade of beta-adrenoceptors with oxprenolol, adrenaline evoked dose-dependent contractions of both longitudinal and circular muscle strips. Storage of the tissues for periods up to 24 hours at 4° C did not modify the responses to adrenaline. Furthermore, the contractions induced by adrenaline following oxprenolol were significantly diminished by the addition of phentolamine, an alpha-adrenoceptor blocking agent. Our results would suggest that oxprenolol has the property of unmasking or revealing alpha receptors responsible for the excitatory effects of adrenaline upon isolated strips of human colon. |
| doi_str_mv | 10.1136/gut.13.8.654 |
| format | Article |
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Our results would suggest that oxprenolol has the property of unmasking or revealing alpha receptors responsible for the excitatory effects of adrenaline upon isolated strips of human colon.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.13.8.654</identifier><identifier>PMID: 5077177</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Colon - drug effects ; Colon - innervation ; Epinephrine - administration & dosage ; Epinephrine - pharmacology ; Humans ; In Vitro Techniques ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - innervation ; Oxprenolol - pharmacology ; Phentolamine - pharmacology ; Receptors, Adrenergic ; Stimulation, Chemical ; Time Factors ; Tissue Preservation</subject><ispartof>Gut, 1972-08, Vol.13 (8), p.654-657</ispartof><rights>Copyright BMJ Publishing Group LTD Aug 1972</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b543t-ca4cd30463e95e9c53fe8fa9dd8b4f819aa543c6639e2089d995f1b05ab0f4683</citedby><cites>FETCH-LOGICAL-b543t-ca4cd30463e95e9c53fe8fa9dd8b4f819aa543c6639e2089d995f1b05ab0f4683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1412267/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1412267/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5077177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gagnon, D. J.</creatorcontrib><creatorcontrib>Devroede, G.</creatorcontrib><creatorcontrib>Belisle, S.</creatorcontrib><title>Excitatory effects of adrenaline upon isolated preparations of human colon</title><title>Gut</title><addtitle>Gut</addtitle><description>The effect of beta-adrenergic blockade with oxprenolol upon adrenaline-induced relaxation of strips of human sigmoid colon was investigated. Following blockade of beta-adrenoceptors with oxprenolol, adrenaline evoked dose-dependent contractions of both longitudinal and circular muscle strips. Storage of the tissues for periods up to 24 hours at 4° C did not modify the responses to adrenaline. Furthermore, the contractions induced by adrenaline following oxprenolol were significantly diminished by the addition of phentolamine, an alpha-adrenoceptor blocking agent. Our results would suggest that oxprenolol has the property of unmasking or revealing alpha receptors responsible for the excitatory effects of adrenaline upon isolated strips of human colon.</description><subject>Colon - drug effects</subject><subject>Colon - innervation</subject><subject>Epinephrine - administration & dosage</subject><subject>Epinephrine - pharmacology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - innervation</subject><subject>Oxprenolol - pharmacology</subject><subject>Phentolamine - pharmacology</subject><subject>Receptors, Adrenergic</subject><subject>Stimulation, Chemical</subject><subject>Time Factors</subject><subject>Tissue Preservation</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUFv1DAQhS0EKkvhxhUpEhJcyGKv7di-IKFVoaxa4AAIcbEmjt1mSexgO6j997jd1apw4DSH9-nNm3kIPSV4SQhtXl_MeUnoUi4bzu6hBWGNrOlKyvtogTERNRdMPUSPUtpijKVU5AgdcSwEEWKBNidXps-QQ7yurHPW5FQFV0EXrYeh97aap-CrPoUBsu2qKdoJIuQ--Fvwch7BVyYMwT9GDxwMyT7Zz2P09d3Jl_Vpffbp_Yf127O65Yzm2gAzHcWsoVZxqwynzkoHqutky5wkCqBwpmmosissVacUd6TFHFrsym30GL3Z-U5zO9rOWJ8jDHqK_QjxWgfo9d-K7y_1RfitCSOrVSOKwYu9QQy_ZpuyHvtk7DCAt2FOWhKuJOY34PN_wG2YY_lL0uV5GDPKGl6oVzvKxJBStO4QhWB905AuDWlCtdSloYI_uxv_AO8rKXq90_uU7dVBhvhTl-yC64_f1pqJzffPPzZcnxf-5Y5vx-3_N_8BgveprA</recordid><startdate>19720801</startdate><enddate>19720801</enddate><creator>Gagnon, D. 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J. ; Devroede, G. ; Belisle, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b543t-ca4cd30463e95e9c53fe8fa9dd8b4f819aa543c6639e2089d995f1b05ab0f4683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Colon - drug effects</topic><topic>Colon - innervation</topic><topic>Epinephrine - administration & dosage</topic><topic>Epinephrine - pharmacology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - innervation</topic><topic>Oxprenolol - pharmacology</topic><topic>Phentolamine - pharmacology</topic><topic>Receptors, Adrenergic</topic><topic>Stimulation, Chemical</topic><topic>Time Factors</topic><topic>Tissue Preservation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gagnon, D. 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J.</au><au>Devroede, G.</au><au>Belisle, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excitatory effects of adrenaline upon isolated preparations of human colon</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1972-08-01</date><risdate>1972</risdate><volume>13</volume><issue>8</issue><spage>654</spage><epage>657</epage><pages>654-657</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>The effect of beta-adrenergic blockade with oxprenolol upon adrenaline-induced relaxation of strips of human sigmoid colon was investigated. Following blockade of beta-adrenoceptors with oxprenolol, adrenaline evoked dose-dependent contractions of both longitudinal and circular muscle strips. Storage of the tissues for periods up to 24 hours at 4° C did not modify the responses to adrenaline. 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| subjects | Colon - drug effects Colon - innervation Epinephrine - administration & dosage Epinephrine - pharmacology Humans In Vitro Techniques Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Oxprenolol - pharmacology Phentolamine - pharmacology Receptors, Adrenergic Stimulation, Chemical Time Factors Tissue Preservation |
| title | Excitatory effects of adrenaline upon isolated preparations of human colon |
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