Glucagon therapy in acute pancreatitis. Report of a double-blind trial
The results of a double-blind trial of glucagon in 69 patients with acute pancreatitis are reported. In a subgroup of 59 patients statistical analysis showed no significant differences between the glucagon-treated (n = 29; 2 X 5 mg protamine-zinc glucagon intramuscularly per day) and the placebo-tre...
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| Veröffentlicht in: | Gut 1978-03, Vol.19 (3), p.175-179 |
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| creator | Dürr, H K Maroske, D Zelder, O Bode, J C |
| description | The results of a double-blind trial of glucagon in 69 patients with acute pancreatitis are reported. In a subgroup of 59 patients statistical analysis showed no significant differences between the glucagon-treated (n = 29; 2 X 5 mg protamine-zinc glucagon intramuscularly per day) and the placebo-treated (n = 30) subjects for the following data: duration of pain left spontaneously and induced by palpation, amounts of analgesics and antispasmodics required by the patients, duration of hospital stay, amylase activities in serum and 24 hour urine collections. Mortality rates did not differ significantly between the glucagon-treated and the placebo-treated subjects in the total group of 69 patients and in the two subgroups of patients who were treated conservatively (n = 59) and those who underwent laparotomy because of severe peritonitis (n = 10). From the results of this study it is concluded that favourable effects of glucagon upon the course of acute pancreatitis--if they do exist--are not significant. |
| doi_str_mv | 10.1136/gut.19.3.175 |
| format | Article |
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Report of a double-blind trial</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Dürr, H K ; Maroske, D ; Zelder, O ; Bode, J C</creator><creatorcontrib>Dürr, H K ; Maroske, D ; Zelder, O ; Bode, J C</creatorcontrib><description>The results of a double-blind trial of glucagon in 69 patients with acute pancreatitis are reported. In a subgroup of 59 patients statistical analysis showed no significant differences between the glucagon-treated (n = 29; 2 X 5 mg protamine-zinc glucagon intramuscularly per day) and the placebo-treated (n = 30) subjects for the following data: duration of pain left spontaneously and induced by palpation, amounts of analgesics and antispasmodics required by the patients, duration of hospital stay, amylase activities in serum and 24 hour urine collections. Mortality rates did not differ significantly between the glucagon-treated and the placebo-treated subjects in the total group of 69 patients and in the two subgroups of patients who were treated conservatively (n = 59) and those who underwent laparotomy because of severe peritonitis (n = 10). From the results of this study it is concluded that favourable effects of glucagon upon the course of acute pancreatitis--if they do exist--are not significant.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.19.3.175</identifier><identifier>PMID: 344159</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Acute Disease ; Adult ; Aged ; Amylases - blood ; Amylases - urine ; Clinical Trials as Topic ; Double-Blind Method ; Female ; Follow-Up Studies ; Glucagon - therapeutic use ; Humans ; Male ; Middle Aged ; Pancreatitis - drug therapy ; Pancreatitis - mortality</subject><ispartof>Gut, 1978-03, Vol.19 (3), p.175-179</ispartof><rights>Copyright BMJ Publishing Group LTD Mar 1978</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b476t-5ebc28bf74bf80d50feaaea5e0a4c632dcb8cb9349f1fe79a6755efa7c20659a3</citedby><cites>FETCH-LOGICAL-b476t-5ebc28bf74bf80d50feaaea5e0a4c632dcb8cb9349f1fe79a6755efa7c20659a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1411907/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1411907/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/344159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dürr, H K</creatorcontrib><creatorcontrib>Maroske, D</creatorcontrib><creatorcontrib>Zelder, O</creatorcontrib><creatorcontrib>Bode, J C</creatorcontrib><title>Glucagon therapy in acute pancreatitis. Report of a double-blind trial</title><title>Gut</title><addtitle>Gut</addtitle><description>The results of a double-blind trial of glucagon in 69 patients with acute pancreatitis are reported. In a subgroup of 59 patients statistical analysis showed no significant differences between the glucagon-treated (n = 29; 2 X 5 mg protamine-zinc glucagon intramuscularly per day) and the placebo-treated (n = 30) subjects for the following data: duration of pain left spontaneously and induced by palpation, amounts of analgesics and antispasmodics required by the patients, duration of hospital stay, amylase activities in serum and 24 hour urine collections. Mortality rates did not differ significantly between the glucagon-treated and the placebo-treated subjects in the total group of 69 patients and in the two subgroups of patients who were treated conservatively (n = 59) and those who underwent laparotomy because of severe peritonitis (n = 10). From the results of this study it is concluded that favourable effects of glucagon upon the course of acute pancreatitis--if they do exist--are not significant.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Amylases - blood</subject><subject>Amylases - urine</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucagon - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatitis - drug therapy</subject><subject>Pancreatitis - mortality</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1v1DAQxS3E11K4ceQQCalcSLBjO7YvSGjVr1VVpAq4WmPH2XrJxqntIPrfkyrVCnrgNIf3mzdv9BB6S3BFCG0-badcEVXRigj-BK0Ia2RJaymfohXGRJRcMPUSvUpphzGWUpEX6DlljHC1Qqdn_WRhG4Yi37gI413hhwLslF0xwmCjg-yzT1Vx7cYQcxG6Aoo2TKZ3pen90BY5euhfo2cd9Mm9eZhH6Pvpybf1eXn59exi_eWyNEw0ueTO2FqaTjDTSdxy3DkAB9xhYLahdWuNtEZRpjrSOaGgEZy7DoStccMV0CP0efEdJ7N3rXVDjtDrMfo9xDsdwOt_lcHf6G34pQkjRGExGxw_GMRwO7mU9d4n6_oeBhempCWVsqYYz-D7R-AuTHGYn9NECIyZ5HUzUx8XysaQUnTdIQrB-r4cPZejidJ03uIz_u7v-Ad4aWOWy0X2KbvfBxXiT90IKri--rHW682G8OsN01cz_2HhzX73_8N_ACItp7A</recordid><startdate>19780301</startdate><enddate>19780301</enddate><creator>Dürr, H K</creator><creator>Maroske, D</creator><creator>Zelder, O</creator><creator>Bode, J C</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19780301</creationdate><title>Glucagon therapy in acute pancreatitis. Report of a double-blind trial</title><author>Dürr, H K ; Maroske, D ; Zelder, O ; Bode, J C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b476t-5ebc28bf74bf80d50feaaea5e0a4c632dcb8cb9349f1fe79a6755efa7c20659a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Amylases - blood</topic><topic>Amylases - urine</topic><topic>Clinical Trials as Topic</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucagon - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatitis - drug therapy</topic><topic>Pancreatitis - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dürr, H K</creatorcontrib><creatorcontrib>Maroske, D</creatorcontrib><creatorcontrib>Zelder, O</creatorcontrib><creatorcontrib>Bode, J C</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dürr, H K</au><au>Maroske, D</au><au>Zelder, O</au><au>Bode, J C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucagon therapy in acute pancreatitis. Report of a double-blind trial</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1978-03-01</date><risdate>1978</risdate><volume>19</volume><issue>3</issue><spage>175</spage><epage>179</epage><pages>175-179</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>The results of a double-blind trial of glucagon in 69 patients with acute pancreatitis are reported. In a subgroup of 59 patients statistical analysis showed no significant differences between the glucagon-treated (n = 29; 2 X 5 mg protamine-zinc glucagon intramuscularly per day) and the placebo-treated (n = 30) subjects for the following data: duration of pain left spontaneously and induced by palpation, amounts of analgesics and antispasmodics required by the patients, duration of hospital stay, amylase activities in serum and 24 hour urine collections. Mortality rates did not differ significantly between the glucagon-treated and the placebo-treated subjects in the total group of 69 patients and in the two subgroups of patients who were treated conservatively (n = 59) and those who underwent laparotomy because of severe peritonitis (n = 10). From the results of this study it is concluded that favourable effects of glucagon upon the course of acute pancreatitis--if they do exist--are not significant.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>344159</pmid><doi>10.1136/gut.19.3.175</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gut, 1978-03, Vol.19 (3), p.175-179 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute Disease Adult Aged Amylases - blood Amylases - urine Clinical Trials as Topic Double-Blind Method Female Follow-Up Studies Glucagon - therapeutic use Humans Male Middle Aged Pancreatitis - drug therapy Pancreatitis - mortality |
| title | Glucagon therapy in acute pancreatitis. Report of a double-blind trial |
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