Potential difference across the normal and the abnormal gastric mucosa in man
The mucosal potential difference in the body of the stomach was measured in 18 patients with gastric ulcers, five with gastritis, and three with pernicious anaemia. The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patien...
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| Veröffentlicht in: | Gut 1976-12, Vol.17 (12), p.993-997 |
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| creator | Hossenbocus, A Fitzpatrick, P Colin-Jones, D G |
| description | The mucosal potential difference in the body of the stomach was measured in 18 patients with gastric ulcers, five with gastritis, and three with pernicious anaemia. The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulcers and gastritis. The patients with pernicious anaemia had even lower potential differences. In an additional 25 subjects, measurements were made in the duodenal bulb and at five sites in the stomach under direct vision at endoscopy. Biopsies were taken from each site for histology. Subjects with gastritis at the high lesser curve had a significantly lower potential difference at that site than those without gastritis. In the latter group, the potential difference at the high lesser curve was as low as in the antrum, and invariably lower than at the high greater curve. |
| doi_str_mv | 10.1136/gut.17.12.993 |
| format | Article |
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The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulcers and gastritis. The patients with pernicious anaemia had even lower potential differences. In an additional 25 subjects, measurements were made in the duodenal bulb and at five sites in the stomach under direct vision at endoscopy. Biopsies were taken from each site for histology. Subjects with gastritis at the high lesser curve had a significantly lower potential difference at that site than those without gastritis. In the latter group, the potential difference at the high lesser curve was as low as in the antrum, and invariably lower than at the high greater curve.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.17.12.993</identifier><identifier>PMID: 1017720</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Anemia, Pernicious - physiopathology ; Gastric Mucosa - physiology ; Gastric Mucosa - physiopathology ; Gastritis - physiopathology ; Humans ; Potentiometry ; Stomach Ulcer - physiopathology</subject><ispartof>Gut, 1976-12, Vol.17 (12), p.993-997</ispartof><rights>Copyright BMJ Publishing Group LTD Dec 1976</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b481t-83be9e9b8f9966ae76b006e837976ca18f6422c6fdb7cc20fe72e44c63fb4fbc3</citedby><cites>FETCH-LOGICAL-b481t-83be9e9b8f9966ae76b006e837976ca18f6422c6fdb7cc20fe72e44c63fb4fbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1411233/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1411233/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1017720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hossenbocus, A</creatorcontrib><creatorcontrib>Fitzpatrick, P</creatorcontrib><creatorcontrib>Colin-Jones, D G</creatorcontrib><title>Potential difference across the normal and the abnormal gastric mucosa in man</title><title>Gut</title><addtitle>Gut</addtitle><description>The mucosal potential difference in the body of the stomach was measured in 18 patients with gastric ulcers, five with gastritis, and three with pernicious anaemia. The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulcers and gastritis. The patients with pernicious anaemia had even lower potential differences. In an additional 25 subjects, measurements were made in the duodenal bulb and at five sites in the stomach under direct vision at endoscopy. Biopsies were taken from each site for histology. Subjects with gastritis at the high lesser curve had a significantly lower potential difference at that site than those without gastritis. In the latter group, the potential difference at the high lesser curve was as low as in the antrum, and invariably lower than at the high greater curve.</description><subject>Anemia, Pernicious - physiopathology</subject><subject>Gastric Mucosa - physiology</subject><subject>Gastric Mucosa - physiopathology</subject><subject>Gastritis - physiopathology</subject><subject>Humans</subject><subject>Potentiometry</subject><subject>Stomach Ulcer - physiopathology</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtvEzEUhS1EVUJhyRJpJCTEZoJf8WODVAVIq5bHAliwsWznOnWY8RR7BsG_xyRRW9iwsuzz-dzHQegJwXNCmHi5mcY5kXNC51qze2hGuFAto0rdRzOMiWwXkusH6GEpW4yxUpoco2NSBUnxDL37OIyQxmi7Zh1DgAzJQ2N9Hkppxito0pD7Ktq03l2tOzxsbBlz9E0_-aHYJqamt-kROgq2K_D4cJ6gz2_ffFqetZcfVufL08vWcUXGVjEHGrRTQWshLEjhMBagmNRSeEtUEJxSL8LaSe8pDiApcO4FC44H59kJerX3vZ5cD2tfJ8i2M9c59jb_MoON5m8lxSuzGX4YwgmhjFWD5weDPHyfoIymj8VD19kEw1RMbQULrmQFn_0DbocppzqcqRvEmHNJdKXaPbXbW4Zw0wrB5k9KpqZUPxhCTU2p8k_v9n-H3sVy6xfLCD9vZJu_GSGZXJj3X5ZmdbGiZ19fM7Oo_Is97_rtf0r_BqQ6qtY</recordid><startdate>19761201</startdate><enddate>19761201</enddate><creator>Hossenbocus, A</creator><creator>Fitzpatrick, P</creator><creator>Colin-Jones, D G</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19761201</creationdate><title>Potential difference across the normal and the abnormal gastric mucosa in man</title><author>Hossenbocus, A ; 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The results were compared with those of 12 normal volunteers. Significantly lower than normal levels were found in the groups of patients with gastric ulcers and gastritis. The patients with pernicious anaemia had even lower potential differences. In an additional 25 subjects, measurements were made in the duodenal bulb and at five sites in the stomach under direct vision at endoscopy. Biopsies were taken from each site for histology. Subjects with gastritis at the high lesser curve had a significantly lower potential difference at that site than those without gastritis. In the latter group, the potential difference at the high lesser curve was as low as in the antrum, and invariably lower than at the high greater curve.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>1017720</pmid><doi>10.1136/gut.17.12.993</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gut, 1976-12, Vol.17 (12), p.993-997 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Anemia, Pernicious - physiopathology Gastric Mucosa - physiology Gastric Mucosa - physiopathology Gastritis - physiopathology Humans Potentiometry Stomach Ulcer - physiopathology |
| title | Potential difference across the normal and the abnormal gastric mucosa in man |
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